Divergent effects of olfactory receptors on transient receptor potential vanilloid 1 activation by capsaicin and eugenol

Moriyama, Sakura; Takita, Yukie; Hinuma, Shuji et al.

Bioscience, Biotechnology and Biochemistry, 2024, 88(8), 908-917

Number of Access:310（2025-07-18 09:46 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97750

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Title
Divergent effects of olfactory receptors on transient receptor potential vanilloid 1 activation by capsaicin and eugenol
Creator
CreatorName
Moriyama, Sakura
CreatorName
Takita, Yukie
NRID
1000060550522 1000060550522
researchmap permalink
s-hinuma s-hinuma
CreatorName
Hinuma, Shuji
NRID
1000060263406 1000060263406
researchmap permalink
read0186039 read0186039
CreatorName
Kuroda, Shun'ichi
Subject
cAMP
capsaicin
eugenol
olfactory receptors
transient receptor potential vanilloid 1
Description
This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience, Biotechnology and Biochemistry following peer review. The version of record Moriyama S., Takita Y., Hinuma S., et al. Divergent effects of olfactory receptors on transient receptor potential vanilloid 1 activation by capsaicin and eugenol. Bioscience, Biotechnology and Biochemistry 88, 908 (2024); is available online at: https://doi.org/10.1093/bbb/zbae060.
Abstract
We analyzed the effects of olfactory receptors (ORs) on transient receptor potential vanilloid 1 (TRPV1) activation using HEK293T cells co-expressing TRPV1 and OR51E1. We demonstrate here that the effect of OR51E1 on TRPV1 activation varies depending on the two TRPV1 ligands: capsaicin and eugenol. Notably, both of these ligands are vanilloid analogs. OR51E1 enhanced the response of TRPV1 to capsaicin but diminished that to eugenol. OR51E2 also showed similar effects. Based on the susceptibility to the OR's modulatory effects, various TRPV1 ligands could be classified into capsaicin and eugenol types. Activation of OR51E1 enhanced cAMP production. In addition, forskolin exhibited almost identical effects as ORs on TRPV1 responses to both types of ligands. These results suggest that OR51E1-induced cAMP elevation leads to a modification of TRPV1, presumably phosphorylation of TRPV1, which amplifies the susceptibility of TRPV1 to the two types of ligands differently.
Publisher
Oxford University Press
Source Title
Bioscience, Biotechnology and Biochemistry
Volume (Issue)
88(8)
Page
908-917
Date of Issued
2024-08-01
Language
English
Handle URL
https://hdl.handle.net/11094/97750
PISSN
09168451
eISSN
13476947
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1093/bbb/zbae060
Access Rights
embargoed access
CopyRight
The full-text file will be made open to the public on 1 August 2025 in accordance with the publisher's policy.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article