Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes

Nagao, Hirofumi; Nishizawa, Hitoshi; Fukuda, Shiro; Fujishima, Yuya; Kita, Shunbun; Maeda, Norikazu; Bamba, Takeshi; Fukusaki, Eiichiro; Shimomura, Iichiro

doi:https://doi.org/10.1507/endocrj.EJ23-0506

Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes

Nagao, Hirofumi; Nishizawa, Hitoshi; Fukuda, Shiro et al.

Endocrine Journal, 2024, 71(1), 55-63

Number of Access:1,393（2025-07-18 09:57 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97805

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Title	Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes
Creator	NRID 1000070983146 1000070983146 ORCID 0009-0001-1261-4160 0009-0001-1261-4160 researchmap permalink Hirofumi_Nagao Hirofumi_Nagao CreatorName Nagao, Hirofumi
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 CreatorName Nishizawa, Hitoshi
	NRID 1000000896467 1000000896467 researchmap permalink sfukuda-ou sfukuda-ou Scopus Author ID 55766129200 55766129200 CreatorName Fukuda, Shiro
	NRID 1000010779789 1000010779789 researchmap permalink Yuya_Fujishima Yuya_Fujishima Scopus Author ID 54410318600 54410318600 CreatorName Fujishima, Yuya
	NRID 1000010746572 1000010746572 ORCID 0000-0002-8937-0053 0000-0002-8937-0053 researchmap permalink Shunbun_Kita Shunbun_Kita Scopus Author ID 36873116500 36873116500 CreatorName Kita, Shunbun
	NRID 1000030506308 1000030506308 researchmap permalink Adiponectin Adiponectin Scopus Author ID 7401561691 7401561691 CreatorName Maeda, Norikazu
	NRID 1000010432444 1000010432444 researchmap permalink read0090438 read0090438 CreatorName Bamba, Takeshi
	NRID 1000040273594 1000040273594 ORCID 0000-0003-3069-5547 0000-0003-3069-5547 researchmap permalink fukusaki-eiichiro fukusaki-eiichiro Scopus Author ID 35473325000 35473325000 CreatorName Fukusaki, Eiichiro
	NRID 1000060346145 1000060346145 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 CreatorName Shimomura, Iichiro
Subject	Adiponectin
	Glutamate
	Obesity
	Type 2 diabetes
	Visceral fat accumulation
Description	Nagao H., Nishizawa H., Fukuda S., et al. Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes. Endocrine Journal 71, 55 (2024); https://doi.org/10.1507/endocrj.EJ23-0506.
Abstract	Visceral fat accumulation is a major determinant of type 2 diabetes mellitus and cardiovascular diseases. Recent studies have reported that glutamate is the most elevated amino acid in the plasma amino acid profile in patients with obesity and/or visceral fat accumulation. Here, we show the relationship between plasma glutamate and the clinical features of patients with type 2 diabetes. The study subjects were 62 (28 men and 34 women) Japanese patients with type 2 diabetes. Blood profiles, including glutamate and adiponectin (APN) levels and estimated visceral fat area (eVFA), were measured. We also evaluated the plasma amino acid levels in mice with or without obesity by GC/MS analysis. In patients with type 2 diabetes, plasma glutamate was positively correlated with BMI, eVFA, and fasting insulin but negatively correlated with APN and duration of diabetes. Additionally, multiple regression analysis revealed that plasma glutamate was a significant determinant of APN. The plasma glutamate level was most significantly increased in obese mice compared to control mice, and it was negatively correlated with APN. These results suggest that the level of plasma glutamate could be a strong indicator of adipocyte dysfunction in patients with type 2 diabetes.
Publisher	Japan Endocrine Society
Source Title	Endocrine Journal
Volume (Issue)	71(1)
Page	55-63
Date of Issued	2024-01-29
Language	English
Handle URL	https://hdl.handle.net/11094/97805
PISSN	09188959
eISSN	13484540
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1507/endocrj.EJ23-0506
Access Rights	open access
CopyRight	© The Japan Endocrine Society
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Endocrine Journal. 2024, 71(1), p. 55-63
DC.title	Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes
DC.creator	Nagao, Hirofumi
	Nishizawa, Hitoshi
	Fukuda, Shiro
	Fujishima, Yuya
	Kita, Shunbun
	Maeda, Norikazu
	Bamba, Takeshi
	Fukusaki, Eiichiro
	Shimomura, Iichiro
DC.publisher	Japan Endocrine Society
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-01-29
DC.identifier	https://doi.org/10.1507/endocrj.EJ23-0506
DC.subject	Adiponectin
	Glutamate
	Obesity
	Type 2 diabetes
	Visceral fat accumulation
DC.description	Nagao H., Nishizawa H., Fukuda S., et al. Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes. Endocrine Journal 71, 55 (2024); https://doi.org/10.1507/endocrj.EJ23-0506.
DCTERMS.abstract	Visceral fat accumulation is a major determinant of type 2 diabetes mellitus and cardiovascular diseases. Recent studies have reported that glutamate is the most elevated amino acid in the plasma amino acid profile in patients with obesity and/or visceral fat accumulation. Here, we show the relationship between plasma glutamate and the clinical features of patients with type 2 diabetes. The study subjects were 62 (28 men and 34 women) Japanese patients with type 2 diabetes. Blood profiles, including glutamate and adiponectin (APN) levels and estimated visceral fat area (eVFA), were measured. We also evaluated the plasma amino acid levels in mice with or without obesity by GC/MS analysis. In patients with type 2 diabetes, plasma glutamate was positively correlated with BMI, eVFA, and fasting insulin but negatively correlated with APN and duration of diabetes. Additionally, multiple regression analysis revealed that plasma glutamate was a significant determinant of APN. The plasma glutamate level was most significantly increased in obese mice compared to control mice, and it was negatively correlated with APN. These results suggest that the level of plasma glutamate could be a strong indicator of adipocyte dysfunction in patients with type 2 diabetes.
DC.rights	© The Japan Endocrine Society
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	97805
citation_title	Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes
citation_author	Nagao, Hirofumi
	Nishizawa, Hitoshi
	Fukuda, Shiro
	Fujishima, Yuya
	Kita, Shunbun
	Maeda, Norikazu
	Bamba, Takeshi
	Fukusaki, Eiichiro
	Shimomura, Iichiro
citation_publisher	Japan Endocrine Society
citation_language	English
citation_date	2024-01-29
citation_journal_title	Endocrine Journal
citation_volume	71
citation_issue	1
citation_firstpage	55
citation_lastpage	63
citation_doi	https://doi.org/10.1507/endocrj.EJ23-0506
citation_public_url	https://hdl.handle.net/11094/97805

Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes

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