Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning

Yagi, Masashi; Wakisaka, Yushi; Takeno, Jun; Kanada, Shintaro; Tsubouchi, Toshiro; Hamatani, Noriaki; Maruo, Hiroyasu; Takashina, Masaaki; Ishii, Takayoshi; Kanai, Tatsuaki; Shimizu, Shinichi; Ogawa, Kazuhiko

doi:https://doi.org/10.1038/s41598-024-68312-y

Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning

Yagi, Masashi; Wakisaka, Yushi; Takeno, Jun et al.

Scientific Reports, 2024, 14(1), 17440

Number of Access:88（2025-05-21 13:59 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97849

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Title	Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning
Creator	NRID 1000040737491 1000040737491 ORCID 0000-0002-2827-5407 0000-0002-2827-5407 researchmap permalink yagi-masashi yagi-masashi Scopus Author ID 55643361900 55643361900 CreatorName Yagi, Masashi
	CreatorName Wakisaka, Yushi
	CreatorName Takeno, Jun
	CreatorName Kanada, Shintaro
	CreatorName Tsubouchi, Toshiro
	CreatorName Hamatani, Noriaki
	CreatorName Maruo, Hiroyasu
	NRID 1000010392010 1000010392010 researchmap permalink read0118020 read0118020 CreatorName Takashina, Masaaki
	CreatorName Ishii, Takayoshi
	NRID 1000080161149 1000080161149 researchmap permalink read0003611 read0003611 CreatorName Kanai, Tatsuaki
	NRID 1000050463724 1000050463724 researchmap permalink shing shing Scopus Author ID 7403432592 7403432592 CreatorName Shimizu, Shinichi
	NRID 1000040253984 1000040253984 researchmap permalink read0097694 read0097694 Scopus Author ID 7404212602 7404212602 CreatorName Ogawa, Kazuhiko
Description	Yagi M., Wakisaka Y., Takeno J., et al. Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning. Scientific Reports 14, 17440 (2024); https://doi.org/10.1038/s41598-024-68312-y.
Abstract	Few reports have documented how the accuracy of stopping power ratio (SPR) prediction for porous bone tissue affects the dose distribution of scanned carbon-ion beam therapy. The estimated SPR based on single-energy computed tomography (SECT) and dual-energy CT (DECT) were compared for the femur of a Rando phantom which simulates the porosity of human bone, NEOBONE which is the hydroxyapatite synthetic bone substitute, and soft tissue samples. Dose differences between SECT and DECT were evaluated for a scanned carbon-ion therapy treatment plan for the Rando phantom. The difference in the water equivalent length was measured to extract the SPR of the examined samples. The differences for SPR estimated from the DECT-SPR conversion were small with − 1.8% and − 3.3% for the Rando phantom femur and NEOBONE, respectively, whereas the differences for SECT-SPR were between 7.6 and 70.7%, illustrating a 1.5-mm shift of the range and a dose difference of 13.3% at maximum point in the evaluation of the dose distribution. This study demonstrated that the DECT-SPR conversion method better estimated the SPR of the porosity of bone tissues than SECT-SPR followed by the accurate range of the carbon-ion beams on carbon-ion dose calculations.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	14(1)
Page	17440
Date of Issued	2024-07-29
Language	English
Handle URL	https://hdl.handle.net/11094/97849
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-024-68312-y
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14(1), p. 17440
DC.title	Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning
DC.creator	Yagi, Masashi
	Wakisaka, Yushi
	Takeno, Jun
	Kanada, Shintaro
	Tsubouchi, Toshiro
	Hamatani, Noriaki
	Maruo, Hiroyasu
	Takashina, Masaaki
	Ishii, Takayoshi
	Kanai, Tatsuaki
	Shimizu, Shinichi
	Ogawa, Kazuhiko
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-07-29
DC.identifier	https://doi.org/10.1038/s41598-024-68312-y
DC.description	Yagi M., Wakisaka Y., Takeno J., et al. Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning. Scientific Reports 14, 17440 (2024); https://doi.org/10.1038/s41598-024-68312-y.
DCTERMS.abstract	Few reports have documented how the accuracy of stopping power ratio (SPR) prediction for porous bone tissue affects the dose distribution of scanned carbon-ion beam therapy. The estimated SPR based on single-energy computed tomography (SECT) and dual-energy CT (DECT) were compared for the femur of a Rando phantom which simulates the porosity of human bone, NEOBONE which is the hydroxyapatite synthetic bone substitute, and soft tissue samples. Dose differences between SECT and DECT were evaluated for a scanned carbon-ion therapy treatment plan for the Rando phantom. The difference in the water equivalent length was measured to extract the SPR of the examined samples. The differences for SPR estimated from the DECT-SPR conversion were small with − 1.8% and − 3.3% for the Rando phantom femur and NEOBONE, respectively, whereas the differences for SECT-SPR were between 7.6 and 70.7%, illustrating a 1.5-mm shift of the range and a dose difference of 13.3% at maximum point in the evaluation of the dose distribution. This study demonstrated that the DECT-SPR conversion method better estimated the SPR of the porosity of bone tissues than SECT-SPR followed by the accurate range of the carbon-ion beams on carbon-ion dose calculations.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	97849
citation_title	Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning
citation_author	Yagi, Masashi
	Wakisaka, Yushi
	Takeno, Jun
	Kanada, Shintaro
	Tsubouchi, Toshiro
	Hamatani, Noriaki
	Maruo, Hiroyasu
	Takashina, Masaaki
	Ishii, Takayoshi
	Kanai, Tatsuaki
	Shimizu, Shinichi
	Ogawa, Kazuhiko
citation_publisher	Nature Research
citation_language	English
citation_date	2024-07-29
citation_journal_title	Scientific Reports
citation_volume	14
citation_issue	1
citation_firstpage	17440
citation_doi	https://doi.org/10.1038/s41598-024-68312-y
citation_public_url	https://hdl.handle.net/11094/97849

Dosimetric impact of stopping power for human bone porosity with dual-energy computed tomography in scanned carbon-ion therapy treatment planning

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