journal article

Journal Article

Radiological Physics and Technology. 2024

A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy

Springer

English

2024-09-13

https://doi.org/10.1007/s12194-024-00837-3

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12194-024-00837-3.

This study aimed to develop a novel internal target volume (ITV) definition for respiratory motion targets, considering target motion velocity and time. The proposed ITV was evaluated in respiratory-gated radiotherapy. An ITV modified with target motion velocity and time (ITVvt) was defined as an ITV that includes a target motion based on target motion velocity and time. The target motion velocity was calculated using four-dimensional computed tomography (4DCT) images. The ITVvts were created from phantom and clinical 4DCT images. The phantom 4DCT images were acquired using a solid phantom that moved with a sinusoidal waveform (peak-to-peak amplitudes of 10 and 20 mm and cycles of 2–6 s). The clinical 4DCT images were obtained from eight lung cancer cases. In respiratory-gated radiotherapy, the ITVvt was compared with conventional ITVs for beam times of 0.5–2 s within the gating window. The conventional ITV was created by adding a uniform margin as the maximum motion within the gating window. In the phantom images, the maximum volume difference between the ITVvt and conventional ITV was –81.9%. In the clinical images, the maximum volume difference was –53.6%. Shorter respiratory cycles and longer BTs resulted in smaller ITVvt compared with the conventional ITV. Therefore, the proposed ITVvt plan could be used to reduce treatment volumes and doses to normal tissues.

The full-text file will be made open to the public on 13 September 2025 in accordance with the publisher's policy.

98075

A novel internal target volume definition based on velocity and time of respiratory target motion for external beam radiotherapy

Springer

English

2024-09-13

Radiological Physics and Technology

https://doi.org/10.1007/s12194-024-00837-3

https://hdl.handle.net/11094/98075