Genome-wide association study on meningioma risk in Japan: a multicenter prospective study

Yamada, Shuhei; Umehara, Toru; Sonehara, Kyuto; Kijima, Noriyuki; Kawabata, Shuhei; Takano, Koji; Kidani, Tomoki; Hirayama, Ryuichi; Arita, Hideyuki; Okita, Yoshiko; Kinoshita, Manabu; Kagawa, Naoki; Fujinaka, Toshiyuki; Fujita, Toshiaki; Wakayama, Akatsuki; Matsuda, Koichi; Okada, Yukinori; Kishima, Haruhiko

doi:https://doi.org/10.1007/s11060-024-04727-x

Genome-wide association study on meningioma risk in Japan: a multicenter prospective study

Yamada, Shuhei; Umehara, Toru; Sonehara, Kyuto et al.

Journal of Neuro-Oncology, 2024, 169(2), 281-286

Number of Access:72（2025-05-02 14:00 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98095

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Title	Genome-wide association study on meningioma risk in Japan: a multicenter prospective study
Creator	NRID 1000090885518 1000090885518 researchmap permalink shuhei_yamada shuhei_yamada CreatorName Yamada, Shuhei
	NRID 1000020792469 1000020792469 researchmap permalink toru_umehara toru_umehara CreatorName Umehara, Toru
	NRID 1000060975358 1000060975358 CreatorName Sonehara, Kyuto
	NRID 1000080534627 1000080534627 researchmap permalink kiji kiji Scopus Author ID 53463724600 53463724600 ORCID 0000-0003-2103-1909 0000-0003-2103-1909 CreatorName Kijima, Noriyuki
	NRID 1000020764062 1000020764062 researchmap permalink shuheiK shuheiK CreatorName Kawabata, Shuhei
	NRID 1000090649203 1000090649203 researchmap permalink kojitakano kojitakano CreatorName Takano, Koji
	CreatorName Kidani, Tomoki
	NRID 1000020593734 1000020593734 ORCID 0000-0002-3739-6219 0000-0002-3739-6219 researchmap permalink rhirayama rhirayama Scopus Author ID 37034068100 37034068100 CreatorName Hirayama, Ryuichi
	NRID 1000060570570 1000060570570 researchmap permalink hideyukiarita hideyukiarita CreatorName Arita, Hideyuki
	NRID 1000010533797 1000010533797 CreatorName Okita, Yoshiko
	NRID 1000040448064 1000040448064 researchmap permalink manabukinoshita manabukinoshita CreatorName Kinoshita, Manabu
	NRID 1000050444542 1000050444542 researchmap permalink naokikagawa naokikagawa Scopus Author ID 8945727800 8945727800 ORCID 0000-0002-0674-2342 0000-0002-0674-2342 CreatorName Kagawa, Naoki
	NRID 1000000359845 1000000359845 CreatorName Fujinaka, Toshiyuki
	CreatorName Fujita, Toshiaki
	CreatorName Wakayama, Akatsuki
	NRID 1000090401257 1000090401257 CreatorName Matsuda, Koichi
	NRID 1000070727411 1000070727411 ORCID 0000-0002-0311-8472 0000-0002-0311-8472 researchmap permalink yokada yokada Scopus Author ID 7005443464 7005443464 CreatorName Okada, Yukinori
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
Subject	East Asian populations
	Genome-wide association study
	Meningioma
	SNP
Description	The version of record of this article, first published in Journal of Neuro-Oncology, is available online at Publisher’s website: https://doi.org/10.1007/s11060-024-04727-x.
Abstract	Purpose: Although meningiomas are the most common primary intracranial tumors, their genetic etiologies have not been fully elucidated. To date, only two genome-wide association studies (GWASs) have focused on European ancestries, despite ethnic differences in the incidence of meningiomas. The aim of this study was to conduct the first GWAS of Japanese patients with meningiomas to identify the SNPs associated with meningioma susceptibility. Methods: In this multicenter prospective case-control study, we studied 401 Japanese patients with meningioma admitted in five institutions in Japan, and 50,876 control participants of Japanese ancestry enrolled in Biobank Japan. Results: The quality control process yielded 536,319 variants and imputation resulted in 8,224,735 variants on the autosomes and 224,820 variants on the X chromosomes. This GWAS eventually revealed no genetic variants with genome-wide significance (P < 5 × 10 − 8) and observed no significant association in the previously reported risk variants rs11012732 and rs2686876 due to low minor allele frequency in the Japanese population. Conclusion: This is the first GWAS of meningiomas in East Asian populations and is expected to contribute to the development of GWAS research for meningiomas.
Publisher	Springer
Source Title	Journal of Neuro-Oncology
Volume (Issue)	169(2)
Page	281-286
Date of Issued	2024-09-01
Language	English
Handle URL	https://hdl.handle.net/11094/98095
PISSN	0167594X
eISSN	15737373
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s11060-024-04727-x
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Journal of Neuro-Oncology. 2024, 169(2), p. 281-286
DC.title	Genome-wide association study on meningioma risk in Japan: a multicenter prospective study
DC.creator	Yamada, Shuhei
	Umehara, Toru
	Sonehara, Kyuto
	Kijima, Noriyuki
	Kawabata, Shuhei
	Takano, Koji
	Kidani, Tomoki
	Hirayama, Ryuichi
	Arita, Hideyuki
	Okita, Yoshiko
	Kinoshita, Manabu
	Kagawa, Naoki
	Fujinaka, Toshiyuki
	Fujita, Toshiaki
	Wakayama, Akatsuki
	Matsuda, Koichi
	Okada, Yukinori
	Kishima, Haruhiko
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-09-01
DC.identifier	https://doi.org/10.1007/s11060-024-04727-x
DC.subject	East Asian populations
	Genome-wide association study
	Meningioma
	SNP
DC.description	The version of record of this article, first published in Journal of Neuro-Oncology, is available online at Publisher’s website: https://doi.org/10.1007/s11060-024-04727-x.
DCTERMS.abstract	Purpose: Although meningiomas are the most common primary intracranial tumors, their genetic etiologies have not been fully elucidated. To date, only two genome-wide association studies (GWASs) have focused on European ancestries, despite ethnic differences in the incidence of meningiomas. The aim of this study was to conduct the first GWAS of Japanese patients with meningiomas to identify the SNPs associated with meningioma susceptibility. Methods: In this multicenter prospective case-control study, we studied 401 Japanese patients with meningioma admitted in five institutions in Japan, and 50,876 control participants of Japanese ancestry enrolled in Biobank Japan. Results: The quality control process yielded 536,319 variants and imputation resulted in 8,224,735 variants on the autosomes and 224,820 variants on the X chromosomes. This GWAS eventually revealed no genetic variants with genome-wide significance (P < 5 × 10 − 8) and observed no significant association in the previously reported risk variants rs11012732 and rs2686876 due to low minor allele frequency in the Japanese population. Conclusion: This is the first GWAS of meningiomas in East Asian populations and is expected to contribute to the development of GWAS research for meningiomas.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98095
citation_title	Genome-wide association study on meningioma risk in Japan: a multicenter prospective study
citation_author	Yamada, Shuhei
	Umehara, Toru
	Sonehara, Kyuto
	Kijima, Noriyuki
	Kawabata, Shuhei
	Takano, Koji
	Kidani, Tomoki
	Hirayama, Ryuichi
	Arita, Hideyuki
	Okita, Yoshiko
	Kinoshita, Manabu
	Kagawa, Naoki
	Fujinaka, Toshiyuki
	Fujita, Toshiaki
	Wakayama, Akatsuki
	Matsuda, Koichi
	Okada, Yukinori
	Kishima, Haruhiko
citation_publisher	Springer
citation_language	English
citation_date	2024-09-01
citation_journal_title	Journal of Neuro-Oncology
citation_volume	169
citation_issue	2
citation_firstpage	281
citation_lastpage	286
citation_doi	https://doi.org/10.1007/s11060-024-04727-x
citation_public_url	https://hdl.handle.net/11094/98095

Genome-wide association study on meningioma risk in Japan: a multicenter prospective study

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