Abnormal localized [¹⁸F]FDG accumulation in a Hoffman 3D brain phantom caused by Pseudomonas aeruginosa and Stenotrophomonas maltophilia

Kamiya, Takashi; Naka, Sadahiro; Watabe, Tadashi; Matsunaga, Keiko; Isohashi, Kayako; Sasaki, Hidetaka; Okamura, Keita; Iwao, Kana; Yabata, Isamu; Tatsumi, Mitsuaki; Kato, Hiroki; Fujino, Koichi

doi:https://doi.org/10.1007/s00259-024-06816-5

Abnormal localized [¹⁸F]FDG accumulation in a Hoffman 3D brain phantom caused by Pseudomonas aeruginosa and Stenotrophomonas maltophilia

Kamiya, Takashi; Naka, Sadahiro; Watabe, Tadashi et al.

European Journal of Nuclear Medicine and Molecular Imaging, 2024, 51(13), 4183-4184

Number of Access:1,444（2025-07-28 20:28 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98099

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Title	Abnormal localized [¹⁸F]FDG accumulation in a Hoffman 3D brain phantom caused by Pseudomonas aeruginosa and Stenotrophomonas maltophilia
Creator	NRID 1000080550764 1000080550764 CreatorName Kamiya, Takashi
	NRID 1000060599843 1000060599843 researchmap permalink _sada_ _sada_ CreatorName Naka, Sadahiro
	NRID 1000090648932 1000090648932 ORCID 0000-0001-8658-2395 0000-0001-8658-2395 researchmap permalink twosaka2018 twosaka2018 Scopus Author ID 57421862900 57421862900 CreatorName Watabe, Tadashi
	NRID 1000080727454 1000080727454 researchmap permalink k_matsunaga k_matsunaga Scopus Author ID 57191729788 57191729788 CreatorName Matsunaga, Keiko
	NRID 1000050598604 1000050598604 ORCID 0000-0002-2081-3020 0000-0002-2081-3020 researchmap permalink researchmap5849 researchmap5849 CreatorName Isohashi, Kayako
	NRID 1000010738628 1000010738628 CreatorName Sasaki, Hidetaka
	CreatorName Okamura, Keita
	CreatorName Iwao, Kana
	CreatorName Yabata, Isamu
	NRID 1000060397700 1000060397700 ORCID 0000-0003-1778-0421 0000-0003-1778-0421 researchmap permalink mtatsumi mtatsumi Scopus Author ID 7102266657 7102266657 CreatorName Tatsumi, Mitsuaki
	NRID 1000020448054 1000020448054 researchmap permalink kato-h kato-h Scopus Author ID 55585587900 55585587900 CreatorName Kato, Hiroki
	CreatorName Fujino, Koichi
Description	The version of record of this article, first published in European Journal of Nuclear Medicine and Molecular Imaging, is available online at Publisher’s website: https://doi.org/10.1007/s00259-024-06816-5.
Abstract	Hoffman 3D brain phantom was scanned to standardize the image quality in a clinical trial. Dynamic [¹⁸F]fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG PET), which started 15 min after being filled with [¹⁸F]FDG (25 MBq), revealed an abnormally increasing accumulation of [¹⁸F]FDG in the left occipital cortex region at one hour. This abnormal accumulation showed an increasing trend (Fig. 1A, B). The presence of bacteria was suggested by the culture of scrabbed samples taken from the corresponding region in the phantom, later confirmed to be Pseudomonas aeruginosa and Stenotrophomonas maltophilia (Fig. 1C). Pseudomonas aeruginosa is an aerobic Gram-negative rod with a single flagellum at one end. It is a facultative anaerobic bacterium that generates ATP (adenosine triphosphate) necessary for growth by aerobic respiration and grows by oxidative degradation of glucose in the presence of oxygen [1]. Stenotrophomonas maltophilia is a non-fermentative Gram-negative bacterium that consumes proteins and peptides rather than sugars and carbohydrates as carbon and nutrient sources [2]. There have been several reports on the uptakes of [¹⁸F]FDG [3, 4]. We concluded that the abnormal accumulation was caused by FDG-avid bacterium, Pseudomonas aeruginosa and Stenotrophomonas maltophilia.It is preferable to use degassed tap water rather than purified or distilled water to prevent the growth of bacteria. Hoffman 3D brain phantom should be disassembled and completely dried after the scan, especially for multicenter clinical trials.
Publisher	Springer
Source Title	European Journal of Nuclear Medicine and Molecular Imaging
Volume (Issue)	51(13)
Page	4183-4184
Date of Issued	2024-07-10
Language	English
Handle URL	https://hdl.handle.net/11094/98099
PISSN	16197070
eISSN	16197089
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s00259-024-06816-5
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	European Journal of Nuclear Medicine and Molecular Imaging. 2024, 51(13), p. 4183-4184
DC.title	Abnormal localized [¹⁸F]FDG accumulation in a Hoffman 3D brain phantom caused by Pseudomonas aeruginosa and Stenotrophomonas maltophilia
DC.creator	Kamiya, Takashi
	Naka, Sadahiro
	Watabe, Tadashi
	Matsunaga, Keiko
	Isohashi, Kayako
	Sasaki, Hidetaka
	Okamura, Keita
	Iwao, Kana
	Yabata, Isamu
	Tatsumi, Mitsuaki
	Kato, Hiroki
	Fujino, Koichi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-07-10
DC.identifier	https://doi.org/10.1007/s00259-024-06816-5
DC.description	The version of record of this article, first published in European Journal of Nuclear Medicine and Molecular Imaging, is available online at Publisher’s website: https://doi.org/10.1007/s00259-024-06816-5.
DCTERMS.abstract	Hoffman 3D brain phantom was scanned to standardize the image quality in a clinical trial. Dynamic [¹⁸F]fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG PET), which started 15 min after being filled with [¹⁸F]FDG (25 MBq), revealed an abnormally increasing accumulation of [¹⁸F]FDG in the left occipital cortex region at one hour. This abnormal accumulation showed an increasing trend (Fig. 1A, B). The presence of bacteria was suggested by the culture of scrabbed samples taken from the corresponding region in the phantom, later confirmed to be Pseudomonas aeruginosa and Stenotrophomonas maltophilia (Fig. 1C). Pseudomonas aeruginosa is an aerobic Gram-negative rod with a single flagellum at one end. It is a facultative anaerobic bacterium that generates ATP (adenosine triphosphate) necessary for growth by aerobic respiration and grows by oxidative degradation of glucose in the presence of oxygen [1]. Stenotrophomonas maltophilia is a non-fermentative Gram-negative bacterium that consumes proteins and peptides rather than sugars and carbohydrates as carbon and nutrient sources [2]. There have been several reports on the uptakes of [¹⁸F]FDG [3, 4]. We concluded that the abnormal accumulation was caused by FDG-avid bacterium, Pseudomonas aeruginosa and Stenotrophomonas maltophilia.It is preferable to use degassed tap water rather than purified or distilled water to prevent the growth of bacteria. Hoffman 3D brain phantom should be disassembled and completely dried after the scan, especially for multicenter clinical trials.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98099
citation_title	Abnormal localized [¹⁸F]FDG accumulation in a Hoffman 3D brain phantom caused by Pseudomonas aeruginosa and Stenotrophomonas maltophilia
citation_author	Kamiya, Takashi
	Naka, Sadahiro
	Watabe, Tadashi
	Matsunaga, Keiko
	Isohashi, Kayako
	Sasaki, Hidetaka
	Okamura, Keita
	Iwao, Kana
	Yabata, Isamu
	Tatsumi, Mitsuaki
	Kato, Hiroki
	Fujino, Koichi
citation_publisher	Springer
citation_language	English
citation_date	2024-07-10
citation_journal_title	European Journal of Nuclear Medicine and Molecular Imaging
citation_volume	51
citation_issue	13
citation_firstpage	4183
citation_lastpage	4184
citation_doi	https://doi.org/10.1007/s00259-024-06816-5
citation_public_url	https://hdl.handle.net/11094/98099

Abnormal localized [¹⁸F]FDG accumulation in a Hoffman 3D brain phantom caused by Pseudomonas aeruginosa and Stenotrophomonas maltophilia

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