Periodontal tissue susceptibility to glycaemic control in type 2 diabetes

Inoue, Moe; Sakanaka, Akito; Katakami, Naoto; Furuno, Masahiro; Nishizawa, Hitoshi; Omori, Kazuo; Taya, Naohiro; Ishikawa, Asuka; Mayumi, Shota; Tanaka Isomura, Emiko; Takeuchi, Hiroki; Amano, Atsuo; Shimomura, Iichiro; Fukusaki, Eiichiro; Kuboniwa, Masae

doi:https://doi.org/10.1111/dom.15835

Periodontal tissue susceptibility to glycaemic control in type 2 diabetes

Inoue, Moe; Sakanaka, Akito; Katakami, Naoto et al.

Diabetes, Obesity and Metabolism, 2024, 26(10), 4684-4693

Number of Access:2,015（2025-07-18 10:03 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98129

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Title	Periodontal tissue susceptibility to glycaemic control in type 2 diabetes
Creator	CreatorName Inoue, Moe
	NRID 1000090815557 1000090815557 researchmap permalink sknk1022 sknk1022 Scopus Author ID 56814868300 56814868300 ORCID 0000-0001-9733-6886 0000-0001-9733-6886 CreatorName Sakanaka, Akito
	NRID 1000010403049 1000010403049 researchmap permalink naoto.katakami naoto.katakami Scopus Author ID 7003392840 7003392840 CreatorName Katakami, Naoto
	CreatorName Furuno, Masahiro
	NRID 1000020379259 1000020379259 researchmap permalink Hitoshi_Nishizawa Hitoshi_Nishizawa Scopus Author ID 7102282682 7102282682 CreatorName Nishizawa, Hitoshi
	CreatorName Omori, Kazuo
	CreatorName Taya, Naohiro
	CreatorName Ishikawa, Asuka
	CreatorName Mayumi, Shota
	NRID 1000070397701 1000070397701 researchmap permalink read0076452 read0076452 Scopus Author ID 55667115400 55667115400 CreatorName Tanaka Isomura, Emiko
	NRID 1000040572186 1000040572186 researchmap permalink takeuchih takeuchih Scopus Author ID 55007392300 55007392300 CreatorName Takeuchi, Hiroki
	NRID 1000050193024 1000050193024 researchmap permalink read0014208 read0014208 Scopus Author ID 7101649822 7101649822 CreatorName Amano, Atsuo
	NRID 1000060346145 1000060346145 researchmap permalink shimomura_i shimomura_i Scopus Author ID 7006715546 7006715546 ORCID 0000-0002-0851-9603 0000-0002-0851-9603 CreatorName Shimomura, Iichiro
	NRID 1000040273594 1000040273594 ORCID 0000-0003-3069-5547 0000-0003-3069-5547 researchmap permalink fukusaki-eiichiro fukusaki-eiichiro Scopus Author ID 35473325000 35473325000 CreatorName Fukusaki, Eiichiro
	NRID 1000000303983 1000000303983 ORCID 0000-0002-3332-2431 0000-0002-3332-2431 researchmap permalink MasaeKuboniwa_URL MasaeKuboniwa_URL Scopus Author ID 56089471500 56089471500 CreatorName Kuboniwa, Masae
Subject	diabetes complications
	glycaemic control
	insulin secretion
	type 2 diabetes
Description	Inoue M., Sakanaka A., Katakami N., et al. Periodontal tissue susceptibility to glycaemic control in type 2 diabetes. Diabetes, Obesity and Metabolism 26, 4684 (2024); https://doi.org/10.1111/dom.15835.
Abstract	Aim: To assess the direct effect of intensive glycaemic control on periodontal tissues in patients with diabetes mellitus. Materials and Methods: Twenty-nine patients with type 2 diabetes were enrolled and hospitalized to receive a 2-week intensive glycaemic control regimen. We observed and analysed the systemic and oral disease indicators before and after treatment and clarified the indicators related to periodontal inflammation. Results: A significant reduction in glycaemic and periodontal parameters, including glycated albumin levels and periodontal inflamed surface area (PISA), was observed after treatment. The changes in PISA per tooth, indicative of periodontal healing, exhibited a bimodal distribution; the patients were divided into two groups on this basis. Correlations were observed between the changes in PISA per tooth and fasting plasma glucose, acetoacetic acid, and beta-hydroxybutyrate levels in the PISA-improved group. Significantly lower levels of C-peptide, coefficient of variation of R-R interval, and ankle-brachial pressure index were observed before treatment in the PISA non-improved group. Conclusions: Glycaemic control treatment can effectively improve periodontitis in patients with type 2 diabetes, even in the absence of specific periodontal treatments. However, the periodontal responsiveness to glycaemic control treatment depends on the systemic condition of the patient.
Publisher	John Wiley and Sons Inc
Source Title	Diabetes, Obesity and Metabolism
Volume (Issue)	26(10)
Page	4684-4693
Date of Issued	2024-10-01
Language	English
Handle URL	https://hdl.handle.net/11094/98129
PISSN	14628902
eISSN	14631326
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/dom.15835
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Diabetes, Obesity and Metabolism. 2024, 26(10), p. 4684-4693
DC.title	Periodontal tissue susceptibility to glycaemic control in type 2 diabetes
DC.creator	Inoue, Moe
	Sakanaka, Akito
	Katakami, Naoto
	Furuno, Masahiro
	Nishizawa, Hitoshi
	Omori, Kazuo
	Taya, Naohiro
	Ishikawa, Asuka
	Mayumi, Shota
	Tanaka Isomura, Emiko
	Takeuchi, Hiroki
	Amano, Atsuo
	Shimomura, Iichiro
	Fukusaki, Eiichiro
	Kuboniwa, Masae
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-10-01
DC.identifier	https://doi.org/10.1111/dom.15835
DC.subject	diabetes complications
	glycaemic control
	insulin secretion
	type 2 diabetes
DC.description	Inoue M., Sakanaka A., Katakami N., et al. Periodontal tissue susceptibility to glycaemic control in type 2 diabetes. Diabetes, Obesity and Metabolism 26, 4684 (2024); https://doi.org/10.1111/dom.15835.
DCTERMS.abstract	Aim: To assess the direct effect of intensive glycaemic control on periodontal tissues in patients with diabetes mellitus. Materials and Methods: Twenty-nine patients with type 2 diabetes were enrolled and hospitalized to receive a 2-week intensive glycaemic control regimen. We observed and analysed the systemic and oral disease indicators before and after treatment and clarified the indicators related to periodontal inflammation. Results: A significant reduction in glycaemic and periodontal parameters, including glycated albumin levels and periodontal inflamed surface area (PISA), was observed after treatment. The changes in PISA per tooth, indicative of periodontal healing, exhibited a bimodal distribution; the patients were divided into two groups on this basis. Correlations were observed between the changes in PISA per tooth and fasting plasma glucose, acetoacetic acid, and beta-hydroxybutyrate levels in the PISA-improved group. Significantly lower levels of C-peptide, coefficient of variation of R-R interval, and ankle-brachial pressure index were observed before treatment in the PISA non-improved group. Conclusions: Glycaemic control treatment can effectively improve periodontitis in patients with type 2 diabetes, even in the absence of specific periodontal treatments. However, the periodontal responsiveness to glycaemic control treatment depends on the systemic condition of the patient.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	98129
citation_title	Periodontal tissue susceptibility to glycaemic control in type 2 diabetes
citation_author	Inoue, Moe
	Sakanaka, Akito
	Katakami, Naoto
	Furuno, Masahiro
	Nishizawa, Hitoshi
	Omori, Kazuo
	Taya, Naohiro
	Ishikawa, Asuka
	Mayumi, Shota
	Tanaka Isomura, Emiko
	Takeuchi, Hiroki
	Amano, Atsuo
	Shimomura, Iichiro
	Fukusaki, Eiichiro
	Kuboniwa, Masae
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2024-10-01
citation_journal_title	Diabetes, Obesity and Metabolism
citation_volume	26
citation_issue	10
citation_firstpage	4684
citation_lastpage	4693
citation_doi	https://doi.org/10.1111/dom.15835
citation_public_url	https://hdl.handle.net/11094/98129

Periodontal tissue susceptibility to glycaemic control in type 2 diabetes

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