Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study

Onishi, Yuri; Akasaka, Hiroshi; Hatta, Kodai; Terashima, Ken; Yoshida, Shino; Yasunobe, Yukiko; Fujimoto, Taku; Isaka, Masaaki; Godai, Kayo; Kido, Michiko; Kabayama, Mai; Sugimoto, Ken; Masui, Yukie; Matsumoto, Kiyoaki; Yasumoto, Saori; Ogawa, Madoka; Nakagawa, Takeshi; Arai, Yasumichi; Ishizaki, Tatsuro; Gondo, Yasuyuki; Ikebe, Kazunori; Kamide, Kei; Yamamoto, Koichi

doi:https://doi.org/10.1111/ggi.14951

Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study

Onishi, Yuri; Akasaka, Hiroshi; Hatta, Kodai et al.

Geriatrics and Gerontology International, 2024, 24(9), 898-903

Number of Access:3,968（2025-07-28 10:56 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98131

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Title	Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study
Creator	CreatorName Onishi, Yuri
	NRID 1000070468081 1000070468081 researchmap permalink hiroshi-akasaka hiroshi-akasaka Scopus Author ID 35445539600 35445539600 CreatorName Akasaka, Hiroshi
	NRID 1000060845949 1000060845949 researchmap permalink khatta khatta CreatorName Hatta, Kodai
	CreatorName Terashima, Ken
	NRID 1000080962612 1000080962612 researchmap permalink Shino_Yoshida Shino_Yoshida CreatorName Yoshida, Shino
	CreatorName Yasunobe, Yukiko
	NRID 1000010854284 1000010854284 researchmap permalink tfujimoto0319 tfujimoto0319 CreatorName Fujimoto, Taku
	NRID 1000070735505 1000070735505 ORCID 0000-0003-0390-3400 0000-0003-0390-3400 researchmap permalink masaaki-isaka masaaki-isaka CreatorName Isaka, Masaaki
	NRID 1000030708681 1000030708681 researchmap permalink vince vince Scopus Author ID 56781372400 56781372400 CreatorName Godai, Kayo
	NRID 1000000706913 1000000706913 researchmap permalink 051010 051010 Scopus Author ID 56086201900 56086201900 CreatorName Kido, Michiko
	NRID 1000050635498 1000050635498 ORCID 0000-0003-1394-1152 0000-0003-1394-1152 researchmap permalink kabayama kabayama Scopus Author ID 57031780400 57031780400 CreatorName Kabayama, Mai
	NRID 1000020437403 1000020437403 researchmap permalink read0076603 read0076603 CreatorName Sugimoto, Ken
	NRID 1000010415507 1000010415507 CreatorName Masui, Yukie
	CreatorName Matsumoto, Kiyoaki
	NRID 1000060649317 1000060649317 researchmap permalink GSU GSU Scopus Author ID 36503185600 36503185600 CreatorName Yasumoto, Saori
	NRID 1000090626532 1000090626532 researchmap permalink ogawa ogawa CreatorName Ogawa, Madoka
	NRID 1000060636942 1000060636942 ORCID 0000-0001-5533-3169 0000-0001-5533-3169 researchmap permalink spinkids spinkids CreatorName Nakagawa, Takeshi
	NRID 1000020255467 1000020255467 CreatorName Arai, Yasumichi
	NRID 1000030246045 1000030246045 CreatorName Ishizaki, Tatsuro
	NRID 1000040250196 1000040250196 ORCID 0000-0002-9805-2807 0000-0002-9805-2807 researchmap permalink ygondo ygondo Scopus Author ID 55800810400 55800810400 CreatorName Gondo, Yasuyuki
	NRID 1000070273696 1000070273696 researchmap permalink read0185241 read0185241 Scopus Author ID 35494649700 35494649700 ORCID 0000-0001-5696-6785 0000-0001-5696-6785 CreatorName Ikebe, Kazunori
	NRID 1000080393239 1000080393239 researchmap permalink kamide kamide Scopus Author ID 7102978326 7102978326 ORCID 0000-0003-1720-2218 0000-0003-1720-2218 CreatorName Kamide, Kei
	NRID 1000000528424 1000000528424 ORCID 0000-0003-0107-9315 0000-0003-0107-9315 researchmap permalink kymt0410 kymt0410 Scopus Author ID 55624482466 55624482466 CreatorName Yamamoto, Koichi
Subject	grip strength
	skeletal muscle
	SONIC study
	vitamin D
Description	Onishi Y., Akasaka H., Hatta K., et al. Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study. Geriatrics and Gerontology International, (2024); https://doi.org/10.1111/ggi.14951.
Abstract	Aim: Vitamin D (VD) affects skeletal muscles. The high prevalence of VD deficiency in Japan may lead to decreased skeletal muscle mass and strength, increasing the prevalence of sarcopenia. Therefore, we aimed to investigate the association between serum VD levels and skeletal muscle indices in a Japanese community-dwelling older population. Methods: We extracted data from the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study. We analyzed the data for participants in the 70s and 90s age groups. Skeletal mass index (SMI) using bioimpedance analysis, grip strength, walking speed, and serum VD levels using 25-hydroxyvitamin D [25(OH)D] were measured. Results: We analyzed the data of 310 participants in their 70s and 48 in their 90s. Mean serum 25(OH)D levels were 21.6 ± 5.0 ng/mL in the 70s group and 23.4 ± 9.1 ng/mL in the 90s group. In the 70s group, serum 25(OH)D levels correlated with SMI (r = 0.21, P < 0.0001) and grip strength (r = 0.30, P < 0.0001). Serum 25(OH)D levels were independently associated with SMI after adjusting for sex, body mass index, and serum albumin levels. In the 90s group, serum 25(OH)D levels were correlated with SMI (r = 0.29, P = 0.049) and grip strength (r = 0.34, P = 0.018). However, the multivariate analysis showed no independent association between SMI, grip strength, and serum 25(OH)D levels. Conclusion: In a cross-sectional analysis of an older population, serum VD levels were associated with SMI and grip strength, and this association was more pronounced in the 70s group than in the 90s group. Our results suggest that serum VD levels maintain skeletal muscle mass and grip strength.
Publisher	John Wiley and Sons Inc
Source Title	Geriatrics and Gerontology International
Volume (Issue)	24(9)
Page	898-903
Date of Issued	2024-08-01
Language	English
Handle URL	https://hdl.handle.net/11094/98131
PISSN	14441586
eISSN	14470594
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/ggi.14951
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Geriatrics and Gerontology International. 2024, 24(9), p. 898-903
DC.title	Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study
DC.creator	Onishi, Yuri
	Akasaka, Hiroshi
	Hatta, Kodai
	Terashima, Ken
	Yoshida, Shino
	Yasunobe, Yukiko
	Fujimoto, Taku
	Isaka, Masaaki
	Godai, Kayo
	Kido, Michiko
	Kabayama, Mai
	Sugimoto, Ken
	Masui, Yukie
	Matsumoto, Kiyoaki
	Yasumoto, Saori
	Ogawa, Madoka
	Nakagawa, Takeshi
	Arai, Yasumichi
	Ishizaki, Tatsuro
	Gondo, Yasuyuki
	Ikebe, Kazunori
	Kamide, Kei
	Yamamoto, Koichi
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-08-01
DC.identifier	https://doi.org/10.1111/ggi.14951
DC.subject	grip strength
	skeletal muscle
	SONIC study
	vitamin D
DC.description	Onishi Y., Akasaka H., Hatta K., et al. Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study. Geriatrics and Gerontology International, (2024); https://doi.org/10.1111/ggi.14951.
DCTERMS.abstract	Aim: Vitamin D (VD) affects skeletal muscles. The high prevalence of VD deficiency in Japan may lead to decreased skeletal muscle mass and strength, increasing the prevalence of sarcopenia. Therefore, we aimed to investigate the association between serum VD levels and skeletal muscle indices in a Japanese community-dwelling older population. Methods: We extracted data from the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC) study. We analyzed the data for participants in the 70s and 90s age groups. Skeletal mass index (SMI) using bioimpedance analysis, grip strength, walking speed, and serum VD levels using 25-hydroxyvitamin D [25(OH)D] were measured. Results: We analyzed the data of 310 participants in their 70s and 48 in their 90s. Mean serum 25(OH)D levels were 21.6 ± 5.0 ng/mL in the 70s group and 23.4 ± 9.1 ng/mL in the 90s group. In the 70s group, serum 25(OH)D levels correlated with SMI (r = 0.21, P < 0.0001) and grip strength (r = 0.30, P < 0.0001). Serum 25(OH)D levels were independently associated with SMI after adjusting for sex, body mass index, and serum albumin levels. In the 90s group, serum 25(OH)D levels were correlated with SMI (r = 0.29, P = 0.049) and grip strength (r = 0.34, P = 0.018). However, the multivariate analysis showed no independent association between SMI, grip strength, and serum 25(OH)D levels. Conclusion: In a cross-sectional analysis of an older population, serum VD levels were associated with SMI and grip strength, and this association was more pronounced in the 70s group than in the 90s group. Our results suggest that serum VD levels maintain skeletal muscle mass and grip strength.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	98131
citation_title	Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study
citation_author	Onishi, Yuri
	Akasaka, Hiroshi
	Hatta, Kodai
	Terashima, Ken
	Yoshida, Shino
	Yasunobe, Yukiko
	Fujimoto, Taku
	Isaka, Masaaki
	Godai, Kayo
	Kido, Michiko
	Kabayama, Mai
	Sugimoto, Ken
	Masui, Yukie
	Matsumoto, Kiyoaki
	Yasumoto, Saori
	Ogawa, Madoka
	Nakagawa, Takeshi
	Arai, Yasumichi
	Ishizaki, Tatsuro
	Gondo, Yasuyuki
	Ikebe, Kazunori
	Kamide, Kei
	Yamamoto, Koichi
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2024-08-01
citation_journal_title	Geriatrics and Gerontology International
citation_volume	24
citation_issue	9
citation_firstpage	898
citation_lastpage	903
citation_doi	https://doi.org/10.1111/ggi.14951
citation_public_url	https://hdl.handle.net/11094/98131

Association between serum vitamin D levels and skeletal muscle indices in an older Japanese population: The SONIC study

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