CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells

Nishimura, Junya; Morita, Yoshihiro; Tobe-Nishimoto, Ayano; Kitahira, Yukiko; Takayama, Shun; Kishimoto, Satoko; Matsumiya-Matsumoto, Yuka; Takeshita, Akinori; Matsunaga, Kazuhide; Imai, Tomoaki; Uzawa, Narikazu

doi:https://doi.org/10.1016/j.intimp.2024.112377

CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells

Nishimura, Junya; Morita, Yoshihiro; Tobe-Nishimoto, Ayano et al.

International Immunopharmacology, 2024, 136, 112377

Number of Access:1,169（2025-07-22 20:38 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98171

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Title	CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells
Creator	CreatorName Nishimura, Junya
	NRID 1000030590517 1000030590517 researchmap permalink yoshi197 yoshi197 Scopus Author ID 16069264600 16069264600 CreatorName Morita, Yoshihiro
	CreatorName Tobe-Nishimoto, Ayano
	CreatorName Kitahira, Yukiko
	CreatorName Takayama, Shun
	NRID 1000070912228 1000070912228 researchmap permalink 10_12 10_12 CreatorName Kishimoto, Satoko
	NRID 1000080817023 1000080817023 researchmap permalink y.m.2941 y.m.2941 CreatorName Matsumiya-Matsumoto, Yuka
	NRID 1000080899005 1000080899005 researchmap permalink oralsurg2 oralsurg2 CreatorName Takeshita, Akinori
	NRID 1000080368323 1000080368323 researchmap permalink kazuhide kazuhide Scopus Author ID 7202702921 7202702921 CreatorName Matsunaga, Kazuhide
	NRID 1000080599598 1000080599598 researchmap permalink 67101 67101 CreatorName Imai, Tomoaki
	NRID 1000030345285 1000030345285 researchmap permalink read0212957 read0212957 Scopus Author ID 6603144046 6603144046 CreatorName Uzawa, Narikazu
Subject	Chemotherapy
	Desmoplasia-like change
	Oral cancer
	Senescence
	Tumor microenvironment
Description	Nishimura J., Morita Y., Tobe-Nishimoto A., et al. CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells. International Immunopharmacology 136, 112377 (2024); https://doi.org/10.1016/j.intimp.2024.112377.
Abstract	The tumor microenvironment (TME) concept has been proposed and is currently being actively studied. The development of extracellular matrix (ECM) in the TME is known as desmoplasia and is observed in many solid tumors. It has also been strongly associated with poor prognosis and resistance to drug therapy. Recently, cellular senescence has gained attention as an effect of drug therapy on cancer cells. Cellular senescence is a phenomenon wherein proliferating cells become resistant to growth-promoting stimuli, secrete the SASP (senescence-associated phenotypic) factors, and stably arrest the cell cycle. These proteins are rich in pro-inflammatory factors, such as interleukin (IL)-6, IL-8, C-X-C motif chemokine ligand 1, C–C motif chemokine ligand (CCL)2, CCL5, and matrix metalloproteinase 3. This study aimed to investigate the desmoplasia-like changes in the TME before and after cancer drug therapy in oral squamous cell carcinomas, evaluate the effect of anticancer drugs on the TME, and the potential involvement of cancer cell senescence. Using a syngeneic oral cancer transplant mouse model, we confirmed that cis-diamminedichloroplatinum (II) (CDDP) administration caused desmoplasia-like changes in cancer tissues. Furthermore, CDDP treatment-induced senescence in tumor-bearing mouse tumor tissues and cultured cancer cells. These results suggest CDDP administration-induced desmoplasia-like structural changes in the TME are related to cellular senescence. Our findings suggest that the administration of anticancer drugs alters the TME of oral cancer cells. Additionally, oral cancer cells undergo senescence, which may influence the TME through the production of SASP factors.
Publisher	Elsevier B.V.
Source Title	International Immunopharmacology
Volume (Issue)	136
Page	112377
Date of Issued	2024-07-30
Language	English
Handle URL	https://hdl.handle.net/11094/98171
PISSN	15675769
eISSN	18781705
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.intimp.2024.112377
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	International Immunopharmacology. 2024, 136, p. 112377
DC.title	CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells
DC.creator	Nishimura, Junya
	Morita, Yoshihiro
	Tobe-Nishimoto, Ayano
	Kitahira, Yukiko
	Takayama, Shun
	Kishimoto, Satoko
	Matsumiya-Matsumoto, Yuka
	Takeshita, Akinori
	Matsunaga, Kazuhide
	Imai, Tomoaki
	Uzawa, Narikazu
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-07-30
DC.identifier	https://doi.org/10.1016/j.intimp.2024.112377
DC.subject	Chemotherapy
	Desmoplasia-like change
	Oral cancer
	Senescence
	Tumor microenvironment
DC.description	Nishimura J., Morita Y., Tobe-Nishimoto A., et al. CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells. International Immunopharmacology 136, 112377 (2024); https://doi.org/10.1016/j.intimp.2024.112377.
DCTERMS.abstract	The tumor microenvironment (TME) concept has been proposed and is currently being actively studied. The development of extracellular matrix (ECM) in the TME is known as desmoplasia and is observed in many solid tumors. It has also been strongly associated with poor prognosis and resistance to drug therapy. Recently, cellular senescence has gained attention as an effect of drug therapy on cancer cells. Cellular senescence is a phenomenon wherein proliferating cells become resistant to growth-promoting stimuli, secrete the SASP (senescence-associated phenotypic) factors, and stably arrest the cell cycle. These proteins are rich in pro-inflammatory factors, such as interleukin (IL)-6, IL-8, C-X-C motif chemokine ligand 1, C–C motif chemokine ligand (CCL)2, CCL5, and matrix metalloproteinase 3. This study aimed to investigate the desmoplasia-like changes in the TME before and after cancer drug therapy in oral squamous cell carcinomas, evaluate the effect of anticancer drugs on the TME, and the potential involvement of cancer cell senescence. Using a syngeneic oral cancer transplant mouse model, we confirmed that cis-diamminedichloroplatinum (II) (CDDP) administration caused desmoplasia-like changes in cancer tissues. Furthermore, CDDP treatment-induced senescence in tumor-bearing mouse tumor tissues and cultured cancer cells. These results suggest CDDP administration-induced desmoplasia-like structural changes in the TME are related to cellular senescence. Our findings suggest that the administration of anticancer drugs alters the TME of oral cancer cells. Additionally, oral cancer cells undergo senescence, which may influence the TME through the production of SASP factors.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	98171
citation_title	CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells
citation_author	Nishimura, Junya
	Morita, Yoshihiro
	Tobe-Nishimoto, Ayano
	Kitahira, Yukiko
	Takayama, Shun
	Kishimoto, Satoko
	Matsumiya-Matsumoto, Yuka
	Takeshita, Akinori
	Matsunaga, Kazuhide
	Imai, Tomoaki
	Uzawa, Narikazu
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2024-07-30
citation_journal_title	International Immunopharmacology
citation_volume	136
citation_firstpage	112377
citation_doi	https://doi.org/10.1016/j.intimp.2024.112377
citation_public_url	https://hdl.handle.net/11094/98171

CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells

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