Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer

Itami, Takefumi; Kurokawa, Yukinori; Yoshioka, Ryo; Saito, Takuro; Yamamoto, Kazuyoshi; Takahashi, Tsuyoshi; Momose, Kota; Yamashita, Kotaro; Tanaka, Koji; Makino, Tomoki; Nakajima, Kiyokazu; Eguchi, Hidetoshi; Doki, Yuichiro

doi:https://doi.org/10.1016/j.ejso.2024.108564

Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer

Itami, Takefumi; Kurokawa, Yukinori; Yoshioka, Ryo et al.

European Journal of Surgical Oncology, 2024, 50(10), 108564

Number of Access:2,066（2025-07-18 17:18 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98173

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Title	Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer
Creator	CreatorName Itami, Takefumi
	NRID 1000010470197 1000010470197 researchmap permalink krkw krkw Scopus Author ID 7202562410 7202562410 CreatorName Kurokawa, Yukinori
	CreatorName Yoshioka, Ryo
	NRID 1000020646468 1000020646468 researchmap permalink tsaito19 tsaito19 Scopus Author ID 57211629912 57211629912 CreatorName Saito, Takuro
	NRID 1000070528637 1000070528637 researchmap permalink kymamoto13 kymamoto13 Scopus Author ID 12764120500 12764120500 CreatorName Yamamoto, Kazuyoshi
	NRID 1000050452389 1000050452389 ORCID 0000-0003-2397-1478 0000-0003-2397-1478 researchmap permalink mihogaoka13611 mihogaoka13611 Scopus Author ID 56182761100 56182761100 CreatorName Takahashi, Tsuyoshi
	NRID 1000050749752 1000050749752 researchmap permalink kom2005 kom2005 CreatorName Momose, Kota
	NRID 1000020747159 1000020747159 researchmap permalink k-yamashita k-yamashita Scopus Author ID 57191498316 57191498316 CreatorName Yamashita, Kotaro
	NRID 1000070621019 1000070621019 ORCID 0000-0001-5178-9388 0000-0001-5178-9388 researchmap permalink koji_tanaka koji_tanaka Scopus Author ID 55628548952 55628548952 CreatorName Tanaka, Koji
	NRID 1000080528620 1000080528620 researchmap permalink _-_-_- _-_-_- Scopus Author ID 56339970700 56339970700 CreatorName Makino, Tomoki
	NRID 1000030432537 1000030432537 researchmap permalink project_engine project_engine Scopus Author ID 7404396263 7404396263 ORCID 0000-0001-8635-7585 0000-0001-8635-7585 CreatorName Nakajima, Kiyokazu
	NRID 1000090542118 1000090542118 researchmap permalink abcdabcdabcd abcdabcdabcd Scopus Author ID 7101627772 7101627772 CreatorName Eguchi, Hidetoshi
	NRID 1000020291445 1000020291445 researchmap permalink ydoki3251 ydoki3251 Scopus Author ID 7006390687 7006390687 CreatorName Doki, Yuichiro
Subject	Drain
	Gastrectomy
	Gastric cancer
	IL-6
	Postoperative complication
	TNF-α
Description	Itami T., Kurokawa Y., Yoshioka R., et al. Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer. European Journal of Surgical Oncology 50, 108564 (2024); https://doi.org/10.1016/j.ejso.2024.108564.
Abstract	Objective: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are inflammatory cytokines produced in response to biological invasion or infection. Their levels are elevated in the blood and locally. We examined whether measuring IL-6 and TNF-α levels in serum or drainage fluid on postoperative day (POD) 1 could detect infectious complications after minimally invasive surgery for gastric cancer. Methods: This cohort study included 205 consecutive patients who underwent laparoscopic or robot-assisted gastrectomy for gastric cancer between November 2020 and July 2023. We measured serum and drainage fluid IL-6 and TNF-α levels on POD 1 after gastrectomy. Receiver operating characteristic (ROC) curves were created to compare the diagnostic values of each cytokine and serum C-reactive protein levels for detecting postoperative infectious complications. Results: IL-6 and TNF-α levels in the serum or drainage fluid were significantly higher in patients with an infectious complication. In addition, drainage fluid IL-6 levels were significantly different in patients with versus without intra-abdominal abscess. In the ROC curve analysis, serum and drainage fluid IL-6 had the highest AUC values for any infectious complication and intra-abdominal abscess, respectively. POD 1 serum IL-6 level above 47 pg/mL could detect any infectious complication with sensitivity of 74.1 % and specificity of 71.8 %. POD 1 drainage fluid IL-6 level above 14,750 pg/mL had 100 % sensitivity for detecting intra-abdominal abscess with specificity of 56.0 %. Conclusions: Measurement of IL-6 levels in blood and drainage fluid on POD 1 is valuable for early detection of postoperative infectious complications or intra-abdominal abscess after gastric cancer surgery.
Publisher	Elsevier B.V.
Source Title	European Journal of Surgical Oncology
Volume (Issue)	50(10)
Page	108564
Date of Issued	2024-10-01
Language	English
Handle URL	https://hdl.handle.net/11094/98173
PISSN	07487983
eISSN	15322157
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.ejso.2024.108564
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	European Journal of Surgical Oncology. 2024, 50(10), p. 108564
DC.title	Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer
DC.creator	Itami, Takefumi
	Kurokawa, Yukinori
	Yoshioka, Ryo
	Saito, Takuro
	Yamamoto, Kazuyoshi
	Takahashi, Tsuyoshi
	Momose, Kota
	Yamashita, Kotaro
	Tanaka, Koji
	Makino, Tomoki
	Nakajima, Kiyokazu
	Eguchi, Hidetoshi
	Doki, Yuichiro
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-10-01
DC.identifier	https://doi.org/10.1016/j.ejso.2024.108564
DC.subject	Drain
	Gastrectomy
	Gastric cancer
	IL-6
	Postoperative complication
	TNF-α
DC.description	Itami T., Kurokawa Y., Yoshioka R., et al. Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer. European Journal of Surgical Oncology 50, 108564 (2024); https://doi.org/10.1016/j.ejso.2024.108564.
DCTERMS.abstract	Objective: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are inflammatory cytokines produced in response to biological invasion or infection. Their levels are elevated in the blood and locally. We examined whether measuring IL-6 and TNF-α levels in serum or drainage fluid on postoperative day (POD) 1 could detect infectious complications after minimally invasive surgery for gastric cancer. Methods: This cohort study included 205 consecutive patients who underwent laparoscopic or robot-assisted gastrectomy for gastric cancer between November 2020 and July 2023. We measured serum and drainage fluid IL-6 and TNF-α levels on POD 1 after gastrectomy. Receiver operating characteristic (ROC) curves were created to compare the diagnostic values of each cytokine and serum C-reactive protein levels for detecting postoperative infectious complications. Results: IL-6 and TNF-α levels in the serum or drainage fluid were significantly higher in patients with an infectious complication. In addition, drainage fluid IL-6 levels were significantly different in patients with versus without intra-abdominal abscess. In the ROC curve analysis, serum and drainage fluid IL-6 had the highest AUC values for any infectious complication and intra-abdominal abscess, respectively. POD 1 serum IL-6 level above 47 pg/mL could detect any infectious complication with sensitivity of 74.1 % and specificity of 71.8 %. POD 1 drainage fluid IL-6 level above 14,750 pg/mL had 100 % sensitivity for detecting intra-abdominal abscess with specificity of 56.0 %. Conclusions: Measurement of IL-6 levels in blood and drainage fluid on POD 1 is valuable for early detection of postoperative infectious complications or intra-abdominal abscess after gastric cancer surgery.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98173
citation_title	Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer
citation_author	Itami, Takefumi
	Kurokawa, Yukinori
	Yoshioka, Ryo
	Saito, Takuro
	Yamamoto, Kazuyoshi
	Takahashi, Tsuyoshi
	Momose, Kota
	Yamashita, Kotaro
	Tanaka, Koji
	Makino, Tomoki
	Nakajima, Kiyokazu
	Eguchi, Hidetoshi
	Doki, Yuichiro
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2024-10-01
citation_journal_title	European Journal of Surgical Oncology
citation_volume	50
citation_issue	10
citation_firstpage	108564
citation_doi	https://doi.org/10.1016/j.ejso.2024.108564
citation_public_url	https://hdl.handle.net/11094/98173

Measuring serum and drainage fluid interleukin-6 and tumor necrosis factor-α levels for early detection of infectious complications after minimally invasive surgery for gastric cancer

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