New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series

Minoda, Saki Sada; Sada, Ryuichi Minoda; Akebo, Hiroyuki et al.

Modern Rheumatology, 2024, 35(2), 249-255

Number of Access:470（2025-08-16 00:38 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98224

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Title
New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series
Creator
CreatorName
Minoda, Saki Sada
NRID
1000040961230 1000040961230
ORCID
0000-0002-1455-6822 0000-0002-1455-6822
researchmap permalink
sadametal sadametal
Scopus Author ID
59319135000 59319135000
CreatorName
Sada, Ryuichi Minoda
CreatorName
Akebo, Hiroyuki
NRID
1000080793984 1000080793984
CreatorName
Tsugihashi, Yukio
CreatorName
Hatta, Kazuhiro
Subject
Lactate dehydrogenase
pH
pleural effusion
pleurisy
rheumatoid arthritis
Description
This is a pre-copyedited, author-produced version of an article accepted for publication in Modern Rheumatology following peer review. The version of record Minoda Saki Sada, Sada Ryuichi Minoda, Akebo Hiroyuki, et al. New perspective on the clinical and laboratory characteristics of rheumatoid pleural effusion: A 29-case series. Modern Rheumatology, (2024) is available online at: https://doi.org/10.1093/mr/roae082.
Abstract
Objective: Rheumatoid pleural effusion (RPE) usually occurs in middle-aged men. Pleural fluid analyses have revealed high lactate dehydrogenase (LDH) levels and low pH and glucose levels in RPE. We aimed to investigate the clinical and laboratory features of patients with RPE since the beginning of the 21st century. Methods: Medical records of patients with RPE were reviewed between May 2006 and October 2021. The patients were divided into <60 year (younger) and ≥60 year (older) groups. Results: The younger group comprised 6 patients (median age 53.5 years, female 33%) and older group comprised 23 patients (median age 76 years, female 52.2%). Compared to the younger group, the older group had fewer cases of fever (83.3 versus 18.2%, P = .007) and chest pain (66.7 versus 8.7%, P = .008). In pleural fluid analysis, the older group presented higher pH (P = .004) and lower LDH levels (P = .044). Seven patients died during the follow-up period. Conclusion: Most patients with RPE were over 60 years of age, and approximately half of them were female. The pleural fluid analysis showed milder inflammation in older patients than in middle-aged patients. The mortality rate of patients with RPE was distinctly higher than that previously reported.
Publisher
Oxford University Press (OUP)
Source Title
Modern Rheumatology
Volume (Issue)
35(2)
Page
249-255
Date of Issued
2024-08-22
Language
English
Handle URL
https://hdl.handle.net/11094/98224
PISSN
14397595
eISSN
14397609
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1093/mr/roae082
Access Rights
embargoed access
CopyRight
The full-text file will be made open to the public on 22 August 2025 in accordance with the publisher's policy.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article