Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma

Yamagata, Kazuki; Yanagawa, Masahiro; Hata, Akinori; Ogawa, Ryo; Kikuchi, Noriko; Doi, Shuhei; Ninomiya, Keisuke; Tokuda, Yukiko; Tomiyama, Noriyuki

doi:https://doi.org/10.1038/s41598-024-69470-9

Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma

Yamagata, Kazuki; Yanagawa, Masahiro; Hata, Akinori et al.

Scientific Reports, 2024, 14, 18310

Number of Access:1,028（2025-08-14 12:34 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98249

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Title	Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma
Creator	CreatorName Yamagata, Kazuki
	NRID 1000000546872 1000000546872 ORCID 0000-0002-0911-6769 0000-0002-0911-6769 researchmap permalink myMY3434 myMY3434 Scopus Author ID 36891136200 36891136200 CreatorName Yanagawa, Masahiro
	NRID 1000010838600 1000010838600 researchmap permalink hataakinori hataakinori Scopus Author ID 57188730692 57188730692 CreatorName Hata, Akinori
	NRID 1000050895654 1000050895654 researchmap permalink 234e 234e CreatorName Ogawa, Ryo
	CreatorName Kikuchi, Noriko
	CreatorName Doi, Shuhei
	CreatorName Ninomiya, Keisuke
	NRID 1000050522744 1000050522744 ORCID 0000-0001-7520-3310 0000-0001-7520-3310 researchmap permalink yukiko_tokuda yukiko_tokuda Scopus Author ID 8872388300 8872388300 CreatorName Tokuda, Yukiko
	NRID 1000050294070 1000050294070 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 CreatorName Tomiyama, Noriyuki
Subject	Dual-energy CT
	Extracellular volume
	Non-small cell lung cancer
	Immune checkpoint inhibitor
	Programmed cell death 1- ligand 1
Description	Yamagata K., Yanagawa M., Hata A., et al. Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma. Scientific Reports 14, 18310 (2024); https://doi.org/10.1038/s41598-024-69470-9.
Abstract	We examined the association between texture features using three-dimensional (3D) io-dine density histogram on delayed phase of dual-energy CT (DECT) and expression of programmed death-ligand 1 (PD-L1) using immunostaining methods in non-small cell lung cancer. Consecutive 37 patients were scanned by DECT. Unenhanced and enhanced (3 min delay) images were obtained. 3D texture analysis was performed for each nodule to obtain 7 features (max, min, median, mean, standard deviation, skewness, and kurtosis) from iodine density mapping and extracellular volume (ECV). A pathologist evaluated a tumor proportion score (TPS, %) using PD-L1 immunostaining: PD-L1 high (TPS ≥ 50%) and low or negative expression (TPS < 50%). Associations between PD-L1 expression and each 8 parameter were evaluated using logistic regression analysis. The multivariate logistic regression analysis revealed that skewness and ECV were independent indicators associated with high PD-L1 expression (skewness: odds ratio [OR] 7.1 [95% CI 1.1, 45.6], p = 0.039; ECV: OR 6.6 [95% CI 1.1, 38.4], p = 0.037). In the receiver-operating characteristic analysis, the area under the curve of the combination of skewness and ECV was 0.83 (95% CI 0.67, 0.93) with sensitivity of 64% and specificity of 96%. Skewness from 3D iodine density histogram and ECV on dual energy CT were significant factors for predicting PD-L1 expression.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	14
Page	18310
Date of Issued	2024-08-07
Language	English
Handle URL	https://hdl.handle.net/11094/98249
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-024-69470-9
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Scientific Reports. 2024, 14, p. 18310
DC.title	Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma
DC.creator	Yamagata, Kazuki
	Yanagawa, Masahiro
	Hata, Akinori
	Ogawa, Ryo
	Kikuchi, Noriko
	Doi, Shuhei
	Ninomiya, Keisuke
	Tokuda, Yukiko
	Tomiyama, Noriyuki
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-08-07
DC.identifier	https://doi.org/10.1038/s41598-024-69470-9
DC.subject	Dual-energy CT
	Extracellular volume
	Non-small cell lung cancer
	Immune checkpoint inhibitor
	Programmed cell death 1- ligand 1
DC.description	Yamagata K., Yanagawa M., Hata A., et al. Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma. Scientific Reports 14, 18310 (2024); https://doi.org/10.1038/s41598-024-69470-9.
DCTERMS.abstract	We examined the association between texture features using three-dimensional (3D) io-dine density histogram on delayed phase of dual-energy CT (DECT) and expression of programmed death-ligand 1 (PD-L1) using immunostaining methods in non-small cell lung cancer. Consecutive 37 patients were scanned by DECT. Unenhanced and enhanced (3 min delay) images were obtained. 3D texture analysis was performed for each nodule to obtain 7 features (max, min, median, mean, standard deviation, skewness, and kurtosis) from iodine density mapping and extracellular volume (ECV). A pathologist evaluated a tumor proportion score (TPS, %) using PD-L1 immunostaining: PD-L1 high (TPS ≥ 50%) and low or negative expression (TPS < 50%). Associations between PD-L1 expression and each 8 parameter were evaluated using logistic regression analysis. The multivariate logistic regression analysis revealed that skewness and ECV were independent indicators associated with high PD-L1 expression (skewness: odds ratio [OR] 7.1 [95% CI 1.1, 45.6], p = 0.039; ECV: OR 6.6 [95% CI 1.1, 38.4], p = 0.037). In the receiver-operating characteristic analysis, the area under the curve of the combination of skewness and ECV was 0.83 (95% CI 0.67, 0.93) with sensitivity of 64% and specificity of 96%. Skewness from 3D iodine density histogram and ECV on dual energy CT were significant factors for predicting PD-L1 expression.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98249
citation_title	Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma
citation_author	Yamagata, Kazuki
	Yanagawa, Masahiro
	Hata, Akinori
	Ogawa, Ryo
	Kikuchi, Noriko
	Doi, Shuhei
	Ninomiya, Keisuke
	Tokuda, Yukiko
	Tomiyama, Noriyuki
citation_publisher	Nature Research
citation_language	English
citation_date	2024-08-07
citation_journal_title	Scientific Reports
citation_volume	14
citation_firstpage	18310
citation_doi	https://doi.org/10.1038/s41598-024-69470-9
citation_public_url	https://hdl.handle.net/11094/98249

Three-dimensional iodine mapping quantified by dual-energy CT for predicting programmed death-ligand 1 expression in invasive pulmonary adenocarcinoma

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