Changes in the analgesic mechanism of oxytocin can contribute to hyperalgesia in Parkinson’s disease model rats

Usami, Nayuka; Maegawa, Hiroharu; Hayashi, Masayoshi et al.

PLoS ONE, 2024, 19(8), e0300081

Number of Access:600（2025-08-14 23:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98259

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Title
Changes in the analgesic mechanism of oxytocin can contribute to hyperalgesia in Parkinson’s disease model rats
Creator
CreatorName
Usami, Nayuka
NRID
1000010711012 1000010711012
researchmap permalink
maega maega
Scopus Author ID
36604752300 36604752300
CreatorName
Maegawa, Hiroharu
CreatorName
Hayashi, Masayoshi
NRID
1000020533110 1000020533110
researchmap permalink
chihokudo chihokudo
Scopus Author ID
6701693347 6701693347
CreatorName
Kudo, Chiho
NRID
1000030218250 1000030218250
researchmap permalink
19580710 19580710
Scopus Author ID
24351577000 24351577000
CreatorName
Niwa, Hitoshi
Description
Usami N., Maegawa H., Hayashi M., et al. (2024) Changes in the analgesic mechanism of oxytocin can contribute to hyperalgesia in Parkinson’s disease model rats. PLoS ONE 19(8): e0300081. doi:10.1371/journal.pone.0300081.
Abstract
Pain is a major non-motor symptom of Parkinson’s disease (PD). Alterations in the descending pain inhibitory system (DPIS) have been reported to trigger hyperalgesia in PD patients. However, the underlying mechanisms remain unclear. In the current study, dopaminergic nigrostriatal lesions were induced in rats by injecting 6-hydroxydopamine (6-OHDA) into their medial forebrain bundle. The neural mechanisms underlying changes in nociception in the orofacial region of 6-OHDA-lesioned rats was examined by injecting formalin into the vibrissa pad. The 6-OHDA-lesioned rats were seen to exhibit increased frequency of face-rubbing and more c-Fos immunoreactive (c-Fos-IR) cells in the trigeminal spinal subnucleus caudalis (Vc), confirming hyperalgesia. Examination of the number of c-Fos-IR cells in the DPIS nuclei [including the midbrain ventrolateral periaqueductal gray, the locus coeruleus, the nucleus raphe magnus, and paraventricular nucleus (PVN)] showed that 6-OHDA-lesioned rats exhibited a significantly lower number of c-Fos-IR cells in the magnocellular division of the PVN (mPVN) after formalin injection compared to sham-operated rats. Moreover, the 6-OHDA-lesioned rats also exhibited significantly lower plasma oxytocin (OT) concentration and percentage of oxytocin-immunoreactive (OT-IR) neurons expressing c-Fos protein in the mPVN and dorsal parvocellular division of the PVN (dpPVN), which secrete the analgesic hormone OT upon activation by nociceptive stimuli, when compared to the sham-operated rats. The effect of OT on hyperalgesia in 6-OHDA-lesioned rats was examined by injecting formalin into the vibrissa pad after intracisternal administration of OT, and the findings showed a decrease in the frequency of face rubbing and the number of c-Fos-IR cells in the Vc. In conclusion, these findings confirm presence of hyperalgesia in PD rats, potentially due to suppression of the analgesic effects of OT originating from the PVN.
Publisher
Public Library of Science
Source Title
PLoS ONE
Volume (Issue)
19(8)
Page
e0300081
Date of Issued
2024-08-20
Language
English
Handle URL
https://hdl.handle.net/11094/98259
eISSN
19326203
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1371/journal.pone.0300081
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open access
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This article is licensed under a Creative Commons Attribution 4.0 International License.
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学術雑誌論文 Journal Article