Ultralow radiant exposure of a short-pulsed laser to disrupt melanosomes with localized thermal damage through a turbid medium

Shimojo, Yu; Nishimura, Takahiro; Tsuruta, Daisuke et al.

Scientific Reports, 2024, 14, 20112

Number of Access:317（2025-08-01 23:35 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98263

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Title
Ultralow radiant exposure of a short-pulsed laser to disrupt melanosomes with localized thermal damage through a turbid medium
Creator
NRID
1000030980734 1000030980734
ORCID
0000-0003-2102-1735 0000-0003-2102-1735
researchmap permalink
yu_shimojo yu_shimojo
CreatorName
Shimojo, Yu
NRID
1000010722829 1000010722829
researchmap permalink
t_nishim t_nishim
Scopus Author ID
36616463600 36616463600
CreatorName
Nishimura, Takahiro
NRID
1000090382043 1000090382043
CreatorName
Tsuruta, Daisuke
NRID
1000050570602 1000050570602
CreatorName
Ozawa, Toshiyuki
Description
Shimojo Y., Nishimura T., Tsuruta D., et al. Ultralow radiant exposure of a short-pulsed laser to disrupt melanosomes with localized thermal damage through a turbid medium. Scientific Reports 14, 20112 (2024); https://doi.org/10.1038/s41598-024-70807-7.
Abstract
Short-pulsed lasers can treat dermal pigmented lesions through selective photothermolysis. The irradiated light experiences multiple scattering by the skin and is absorbed by abnormal melanosomes as well as by normal blood vessels above the target. Because the fluence is extremely high, the absorbed light can cause thermal damage to the adjacent tissue components, leading to complications. To minimize radiant exposure and reduce the risk of burns, a model of the melanosome-disruption threshold fluence (MDTF) has been developed that accounts for the light-propagation efficiency in the skin. However, the light-propagation efficiency is attenuated because of multiple scattering, which limits the extent to which the radiant exposure required for treatment can be reduced. Here, this study demonstrates the principle of melanosome disruption with localized thermal damage through a turbid medium by ultralow radiant exposure of a short-pulsed laser. The MDTF model was combined with a wavefront-shaping technique to design an irradiation condition that can increase the light-propagation efficiency to the target. Under this irradiation condition, melanosomes were disrupted at a radiant exposure 25 times lower than the minimal value used in conventional laser treatments. Furthermore, almost no thermal damage to the skin was confirmed through a numerical simulation. These experimental and numerical results show the potential for noninvasive melanosome disruption and may lead to the improvement of the safety of short-pulsed laser treatment.
Publisher
Nature Research
Source Title
Scientific Reports
Volume (Issue)
14
Page
20112
Date of Issued
2024-08-29
Language
English
Handle URL
https://hdl.handle.net/11094/98263
eISSN
20452322
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1038/s41598-024-70807-7
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article