Helicobacter pylori Infection Affects the Tumor Immune Microenvironment of Esophageal Cancer Patients

Matsuda, Hiroki; Iwahori, Kota; Takeoka, Tomohira et al.

Anticancer Research, 2024, 44(9), 3799-3805

Number of Access:1,294（2025-07-18 17:11 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98307

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Title
Helicobacter pylori Infection Affects the Tumor Immune Microenvironment of Esophageal Cancer Patients
Creator
CreatorName
Matsuda, Hiroki
NRID
1000080566448 1000080566448
researchmap permalink
638ik 638ik
Scopus Author ID
15738420000 15738420000
CreatorName
Iwahori, Kota
CreatorName
Takeoka, Tomohira
CreatorName
Kato, Ryo
NRID
1000040768975 1000040768975
researchmap permalink
surakawa-surakawa surakawa-surakawa
CreatorName
Urakawa, Shinya
NRID
1000020646468 1000020646468
researchmap permalink
tsaito19 tsaito19
Scopus Author ID
57211629912 57211629912
CreatorName
Saito, Takuro
NRID
1000080528620 1000080528620
researchmap permalink
_-_-_- _-_-_-
Scopus Author ID
56339970700 56339970700
CreatorName
Makino, Tomoki
NRID
1000090542118 1000090542118
researchmap permalink
abcdabcdabcd abcdabcdabcd
Scopus Author ID
7101627772 7101627772
CreatorName
Eguchi, Hidetoshi
NRID
1000020291445 1000020291445
researchmap permalink
ydoki3251 ydoki3251
Scopus Author ID
7006390687 7006390687
CreatorName
Doki, Yuichiro
NRID
1000070243459 1000070243459
researchmap permalink
hwada hwada
Scopus Author ID
7402917501 7402917501
CreatorName
Wada, Hisashi
Subject
esophageal cancer
Helicobacter pylori
T cells
Description
Matsuda H., Iwahori K., Takeoka T., et al. Helicobacter pylori Infection Affects the Tumor Immune Microenvironment of Esophageal Cancer Patients. Anticancer Research 44, 3799 (2024); https://doi.org/10.21873/anticanres.17205.
Abstract
Background/Aim: We herein examined T cell immunity in esophageal cancer patients with and without Helicobacter pylori infection to establish a foundation for immunotherapeutic strategies targeting esophageal cancer in the presence of H. pylori infection. Materials and Methods: Twenty-six patients with esophageal squamous cell carcinoma between 2015 and 2017 were enrolled in the present study. Serum antibodies against H. pylori were measured. Fresh tumor tissues were obtained by endoscopic biopsy or from surgical resection. A cell suspension of these tissues was subjected to a flow cytometric analysis. Results: Among the 26 patients analyzed, 10 (38.5%) were seropositive for H. pylori. The flow cytometric analysis of tumor-infiltrating lymphocytes revealed that the percentage of CD103+CD4+ T cells in esophageal tumors was significantly lower in H. pylori-positive patients than in H. pylori-negative patients (p=0.0105). Conversely, the percentage of CD45RA-CD25hi effector Treg cells in esophageal tumors was significantly higher in H. pylori-positive patients than in H. pylori-negative patients (p=0.0022), indicating an immunosuppressive tumor microenvironment in the former. Following neoadjuvant chemotherapy, the number of CD45RA-CD25hi effector Treg cells decreased (p=0.0248). Conclusion: The tumor immune microenvironment of esophageal cancer patients with H. pylori infection exhibited an immunosuppressive phenotype. The targeting of Treg cells has potential in immunotherapy for this patient population.
Publisher
International Institute of Anticancer Research
Source Title
Anticancer Research
Volume (Issue)
44(9)
Page
3799-3805
Date of Issued
2024-09-01
Language
English
Handle URL
https://hdl.handle.net/11094/98307
PISSN
02507005
eISSN
17917530
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.21873/anticanres.17205
Access Rights
open access
CopyRight
© 2024 International Institute of Anticancer Research. All rights reserved.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article