Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases

Ohtani, Hiroki; Inoue, Naoya; Iwatani, Yoshinori; Takeno, Yuri; Arakawa, Yuya; Hidaka, Yoh; Watanabe, Mikio

doi:https://doi.org/10.1016/j.clim.2024.110338

Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases

Ohtani, Hiroki; Inoue, Naoya; Iwatani, Yoshinori et al.

Clinical Immunology, 2024, 267, 110338

Number of Access:1,044（2025-10-31 07:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98323

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Title	Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases
Creator	CreatorName Ohtani, Hiroki
	NRID 1000080710269 1000080710269 researchmap permalink nao1 nao1 CreatorName Inoue, Naoya
	NRID 1000060168581 1000060168581 researchmap permalink read0013695 read0013695 CreatorName Iwatani, Yoshinori
	CreatorName Takeno, Yuri
	NRID 1000030733175 1000030733175 researchmap permalink ara-y ara-y CreatorName Arakawa, Yuya
	NRID 1000030243231 1000030243231 researchmap permalink Y99 Y99 Scopus Author ID 7102099529 7102099529 CreatorName Hidaka, Yoh
	NRID 1000050294088 1000050294088 ORCID 0000-0001-5971-9296 0000-0001-5971-9296 researchmap permalink watanabemikio watanabemikio Scopus Author ID 55793188612 55793188612 CreatorName Watanabe, Mikio
Subject	Autoimmune thyroid disease
	CTLA-4
	Methylation
	Severity
	Single nucleotide polymorphism
Description	Ohtani H., Inoue N., Iwatani Y., et al. Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases. Clinical Immunology 267, 110338 (2024); https://doi.org/10.1016/j.clim.2024.110338.
Abstract	The pathogenesis and manifestation of autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's disease (HD) are associated with T cell activation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a crucial role in the regulation of T cell activation. DNA methylation levels of eight CpG sites in the CTLA4 gene and expression levels of soluble CTLA-4 were examined. Methylation levels of +22 CpG and CT60 CpG-SNPs in patients with GD and HD with the CT60 GG genotype were lower than those in control subjects. Methylation levels of the-15 CpG sites were lower in patients with intractable GD than those in GD patients in remission. These results suggest that demethylation of +22 CpG and CT60 CpG-SNPs may be associated with susceptibility to GD and HD in subjects with the CTLA4 CT60 GG genotype, and that demethylation of −15 CpG may be associated with the intractability of GD.
Publisher	Elsevier B.V.
Source Title	Clinical Immunology
Volume (Issue)	267
Page	110338
Date of Issued	2024-10-01
Language	English
Handle URL	https://hdl.handle.net/11094/98323
PISSN	15216616
eISSN	15217035
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.clim.2024.110338
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Clinical Immunology. 2024, 267, p. 110338
DC.title	Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases
DC.creator	Ohtani, Hiroki
	Inoue, Naoya
	Iwatani, Yoshinori
	Takeno, Yuri
	Arakawa, Yuya
	Hidaka, Yoh
	Watanabe, Mikio
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-10-01
DC.identifier	https://doi.org/10.1016/j.clim.2024.110338
DC.subject	Autoimmune thyroid disease
	CTLA-4
	Methylation
	Severity
	Single nucleotide polymorphism
DC.description	Ohtani H., Inoue N., Iwatani Y., et al. Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases. Clinical Immunology 267, 110338 (2024); https://doi.org/10.1016/j.clim.2024.110338.
DCTERMS.abstract	The pathogenesis and manifestation of autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's disease (HD) are associated with T cell activation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a crucial role in the regulation of T cell activation. DNA methylation levels of eight CpG sites in the CTLA4 gene and expression levels of soluble CTLA-4 were examined. Methylation levels of +22 CpG and CT60 CpG-SNPs in patients with GD and HD with the CT60 GG genotype were lower than those in control subjects. Methylation levels of the-15 CpG sites were lower in patients with intractable GD than those in GD patients in remission. These results suggest that demethylation of +22 CpG and CT60 CpG-SNPs may be associated with susceptibility to GD and HD in subjects with the CTLA4 CT60 GG genotype, and that demethylation of −15 CpG may be associated with the intractability of GD.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	98323
citation_title	Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases
citation_author	Ohtani, Hiroki
	Inoue, Naoya
	Iwatani, Yoshinori
	Takeno, Yuri
	Arakawa, Yuya
	Hidaka, Yoh
	Watanabe, Mikio
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2024-10-01
citation_journal_title	Clinical Immunology
citation_volume	267
citation_firstpage	110338
citation_doi	https://doi.org/10.1016/j.clim.2024.110338
citation_public_url	https://hdl.handle.net/11094/98323

Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases

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