Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction

Fukui, H.; Onishi, H.; Ota, T.; Nakamoto, A.; Tsuboyama, T.; Enchi, Y.; Yamada, D.; Takeda, Y.; Kobayashi, S.; Fukuda, Y.; Eguchi, H.; Matsui, T.; Tatsumi, M.; Tomiyama, N.

doi:https://doi.org/10.1016/j.crad.2024.08.007

Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction

Fukui, H.; Onishi, H.; Ota, T. et al.

Clinical Radiology, 2024, 79(11), e1356-e1365

Number of Access:2,319（2025-07-19 21:04 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98325

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Title	Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction
Creator	NRID 1000000721101 1000000721101 researchmap permalink h-fukui h-fukui Scopus Author ID 57192195026 57192195026 CreatorName Fukui, H.
	CreatorName Onishi, H.
	NRID 1000020868088 1000020868088 researchmap permalink takashi_0123 takashi_0123 Scopus Author ID 57194721064 57194721064 CreatorName Ota, T.
	NRID 1000020625199 1000020625199 researchmap permalink nakamo10 nakamo10 Scopus Author ID 36778686900 36778686900 CreatorName Nakamoto, A.
	NRID 1000000423187 1000000423187 researchmap permalink ttsuboyama ttsuboyama Scopus Author ID 56370777700 56370777700 CreatorName Tsuboyama, T.
	CreatorName Enchi, Y.
	NRID 1000060571396 1000060571396 ORCID 0000-0002-6702-3800 0000-0002-6702-3800 researchmap permalink dyamada79222 dyamada79222 Scopus Author ID 37008067700 37008067700 CreatorName Yamada, D.
	CreatorName Takeda, Y.
	NRID 1000030452436 1000030452436 researchmap permalink 30452436 30452436 Scopus Author ID 7405376089 7405376089 ORCID 0000-0002-8828-1067 0000-0002-8828-1067 CreatorName Kobayashi, S.
	NRID 1000020768973 1000020768973 CreatorName Fukuda, Y.
	NRID 1000090542118 1000090542118 researchmap permalink abcdabcdabcd abcdabcdabcd Scopus Author ID 7101627772 7101627772 CreatorName Eguchi, H.
	NRID 1000050747037 1000050747037 ORCID 0000-0002-6753-1688 0000-0002-6753-1688 researchmap permalink takahiromatsui takahiromatsui Scopus Author ID 35176152500 35176152500 CreatorName Matsui, T.
	NRID 1000060397700 1000060397700 ORCID 0000-0003-1778-0421 0000-0003-1778-0421 researchmap permalink mtatsumi mtatsumi Scopus Author ID 7102266657 7102266657 CreatorName Tatsumi, M.
	NRID 1000050294070 1000050294070 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 CreatorName Tomiyama, N.
Description	Fukui H., Onishi H., Ota T., et al. Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction. Clinical Radiology 79, e1356 (2024); https://doi.org/10.1016/j.crad.2024.08.007.
Abstract	AIMS: To compare the iodine washout rate (IWR) from multiphasic contrast-enhanced computed tomography (CT) with the extracellular volume fraction (fECV) for assessing pancreatic fibrosis and its association with pancreatic cancer. MATERIALS AND METHODS: The study included 51 individuals (33 men; median age: 69 years; 21 with pancreatic cancer, 30 with other diseases) who underwent multiphasic contrast-enhanced CT and histological evaluation for fibrotic changes in pancreas. The histological pancreatic fibrosis fraction (HPFF) was assessed on Azan-stained sections. Pancreatic parenchymal enhancement values were measured to calculate IWR and fECV. Statistical methods, such as Spearman's rho and Mann–Whitney U-test, were used. Linear regression models using IWR and fECV were constructed to predict HPFF, with the performance expressed as root mean squared error (RMSE) and Akaike information criterion (AIC). RESULTS: HPFF correlated with all CT parameters at the estimated transection line, strongest for IWRPPP−EP (r=−0.69, P<0.01). HPFF and fECV values were higher in the pancreatic cancer group than in controls (30% vs. 12.5%, P<0.01; 40.3% vs. 33.0%, P<0.01), whereas IWR values were lower (IWRPPP-EP: 43.3% vs. 55.0%, P<0.01; IWRPVP-EP: 25.0% vs. 33.5%, P<0.01). Linear regression models combining IWRPPP−EP + fECV and IWRPVP−EP + fECV were superior for predicting HPFF, with lower RMSE (9.23–9.35) and AIC (379.38–380.72) values than models with IWR or fECV alone. CONCLUSION: IWRPPP−EP, IWRPVP−EP, and fECV were reliable biomarkers for noninvasively assessing pancreatic fibrosis and were associated with pancreatic cancer risk. Linear regression combining these variables showed enhanced predictive accuracy for pancreatic fibrosis.
Publisher	Elsevier B.V.
Source Title	Clinical Radiology
Volume (Issue)	79(11)
Page	e1356-e1365
Date of Issued	2024-11-01
Language	English
Handle URL	https://hdl.handle.net/11094/98325
PISSN	00099260
eISSN	1365229X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.crad.2024.08.007
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Clinical Radiology. 2024, 79(11), p. e1356-e1365
DC.title	Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction
DC.creator	Fukui, H.
	Onishi, H.
	Ota, T.
	Nakamoto, A.
	Tsuboyama, T.
	Enchi, Y.
	Yamada, D.
	Takeda, Y.
	Kobayashi, S.
	Fukuda, Y.
	Eguchi, H.
	Matsui, T.
	Tatsumi, M.
	Tomiyama, N.
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-11-01
DC.identifier	https://doi.org/10.1016/j.crad.2024.08.007
DC.description	Fukui H., Onishi H., Ota T., et al. Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction. Clinical Radiology 79, e1356 (2024); https://doi.org/10.1016/j.crad.2024.08.007.
DCTERMS.abstract	AIMS: To compare the iodine washout rate (IWR) from multiphasic contrast-enhanced computed tomography (CT) with the extracellular volume fraction (fECV) for assessing pancreatic fibrosis and its association with pancreatic cancer. MATERIALS AND METHODS: The study included 51 individuals (33 men; median age: 69 years; 21 with pancreatic cancer, 30 with other diseases) who underwent multiphasic contrast-enhanced CT and histological evaluation for fibrotic changes in pancreas. The histological pancreatic fibrosis fraction (HPFF) was assessed on Azan-stained sections. Pancreatic parenchymal enhancement values were measured to calculate IWR and fECV. Statistical methods, such as Spearman's rho and Mann–Whitney U-test, were used. Linear regression models using IWR and fECV were constructed to predict HPFF, with the performance expressed as root mean squared error (RMSE) and Akaike information criterion (AIC). RESULTS: HPFF correlated with all CT parameters at the estimated transection line, strongest for IWRPPP−EP (r=−0.69, P<0.01). HPFF and fECV values were higher in the pancreatic cancer group than in controls (30% vs. 12.5%, P<0.01; 40.3% vs. 33.0%, P<0.01), whereas IWR values were lower (IWRPPP-EP: 43.3% vs. 55.0%, P<0.01; IWRPVP-EP: 25.0% vs. 33.5%, P<0.01). Linear regression models combining IWRPPP−EP + fECV and IWRPVP−EP + fECV were superior for predicting HPFF, with lower RMSE (9.23–9.35) and AIC (379.38–380.72) values than models with IWR or fECV alone. CONCLUSION: IWRPPP−EP, IWRPVP−EP, and fECV were reliable biomarkers for noninvasively assessing pancreatic fibrosis and were associated with pancreatic cancer risk. Linear regression combining these variables showed enhanced predictive accuracy for pancreatic fibrosis.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98325
citation_title	Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction
citation_author	Fukui, H.
	Onishi, H.
	Ota, T.
	Nakamoto, A.
	Tsuboyama, T.
	Enchi, Y.
	Yamada, D.
	Takeda, Y.
	Kobayashi, S.
	Fukuda, Y.
	Eguchi, H.
	Matsui, T.
	Tatsumi, M.
	Tomiyama, N.
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2024-11-01
citation_journal_title	Clinical Radiology
citation_volume	79
citation_issue	11
citation_firstpage	e1356
citation_lastpage	e1365
citation_doi	https://doi.org/10.1016/j.crad.2024.08.007
citation_public_url	https://hdl.handle.net/11094/98325

Pancreatic fibrosis assessment and association with pancreatic cancer: comparison with the extracellular volume fraction

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