PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions

Watanabe, Seiya; Shibakita, Hiroaki; Hagiwara, Naruki; Nakajima, Ryosuke; Kato, Hiroyuki S.; Akai-Kasaya, Megumi

doi:https://doi.org/10.1021/acsami.4c12037

PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions

Watanabe, Seiya; Shibakita, Hiroaki; Hagiwara, Naruki et al.

ACS Applied Materials and Interfaces, 2024, 16(40), 54636-54644

Number of Access:447（2025-07-18 21:47 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98354

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Title	PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions
Creator	NRID 1000020850035 1000020850035 ORCID 0000-0001-7422-8452 0000-0001-7422-8452 researchmap permalink seiya129 seiya129 CreatorName Watanabe, Seiya
	CreatorName Shibakita, Hiroaki
	CreatorName Hagiwara, Naruki
	CreatorName Nakajima, Ryosuke
	NRID 1000080300862 1000080300862 researchmap permalink read_hskato read_hskato Scopus Author ID 7406492466 7406492466 CreatorName Kato, Hiroyuki S.
	NRID 1000050437373 1000050437373 researchmap permalink Meg_Aki_Kassy Meg_Aki_Kassy Scopus Author ID 6507985913 6507985913 CreatorName Akai-Kasaya, Megumi
Subject	clinical application
	conductive polymer
	neuromorphic
	polymer wire
	synaptic device
Description	Watanabe S., Shibakita H., Hagiwara N., et al. PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions. ACS Applied Materials and Interfaces 16, 54636 (2024); https://doi.org/10.1021/acsami.4c12037 .
Abstract	Synaptic devices, which are designed to emulate the synaptic functions of neurons, have recently gained attention as key elements in the development of neuromorphic hardware. To date, most synaptic devices utilizing conductive polymer materials, particularly poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), have been designed as three-terminal devices. Nevertheless, a recent study revealed that a single PEDOT:PSS wire can function as a two-terminal synaptic device through additional polymerization, which creates asymmetry in the wire diameter between the anode and cathode. Owing to its high biocompatibility, PEDOT is considered a promising candidate for use in clinical information-processing devices. However, previous studies examined the synaptic function of PEDOT:PSS only in PSS solutions. Therefore, the performance of PEDOT:PSS wires in other solutions, such as physiological saline solutions, remains unknown. Herein, we investigated the effects of operating environmental conditions (including phosphate-buffered saline (PBS)) on the synaptic functions of the asymmetric PEDOT:PSS wire. Our results indicate that the synaptic conductance change in the PEDOT:PSS wire occurred in all investigated aqueous electrolyte solutions. Moreover, we revealed the relationship between the synaptic conductance change behavior and the molecular properties of the electrolyte ions. Furthermore, the waveform of the conductance change can be controlled by adjusting the conditions for wire asymmetrization. These results demonstrate that the PEDOT:PSS wire exhibits a synaptic conductance change, yielding a waveform suitable for machine learning, even under wet conditions (i.e., in any electrolyte solution, including PBS). Therefore, PEDOT:PSS wire is a promising material for two-terminal synaptic devices applicable in clinical studies.
Publisher	American Chemical Society
Source Title	ACS Applied Materials and Interfaces
Volume (Issue)	16(40)
Page	54636-54644
Date of Issued	2024-09-30
Language	English
Handle URL	https://hdl.handle.net/11094/98354
PISSN	19448244
eISSN	19448252
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1021/acsami.4c12037
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	ACS Applied Materials and Interfaces. 2024, 16(40), p. 54636-54644
DC.title	PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions
DC.creator	Watanabe, Seiya
	Shibakita, Hiroaki
	Hagiwara, Naruki
	Nakajima, Ryosuke
	Kato, Hiroyuki S.
	Akai-Kasaya, Megumi
DC.publisher	American Chemical Society
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-09-30
DC.identifier	https://doi.org/10.1021/acsami.4c12037
DC.subject	clinical application
	conductive polymer
	neuromorphic
	polymer wire
	synaptic device
DC.description	Watanabe S., Shibakita H., Hagiwara N., et al. PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions. ACS Applied Materials and Interfaces 16, 54636 (2024); https://doi.org/10.1021/acsami.4c12037 .
DCTERMS.abstract	Synaptic devices, which are designed to emulate the synaptic functions of neurons, have recently gained attention as key elements in the development of neuromorphic hardware. To date, most synaptic devices utilizing conductive polymer materials, particularly poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), have been designed as three-terminal devices. Nevertheless, a recent study revealed that a single PEDOT:PSS wire can function as a two-terminal synaptic device through additional polymerization, which creates asymmetry in the wire diameter between the anode and cathode. Owing to its high biocompatibility, PEDOT is considered a promising candidate for use in clinical information-processing devices. However, previous studies examined the synaptic function of PEDOT:PSS only in PSS solutions. Therefore, the performance of PEDOT:PSS wires in other solutions, such as physiological saline solutions, remains unknown. Herein, we investigated the effects of operating environmental conditions (including phosphate-buffered saline (PBS)) on the synaptic functions of the asymmetric PEDOT:PSS wire. Our results indicate that the synaptic conductance change in the PEDOT:PSS wire occurred in all investigated aqueous electrolyte solutions. Moreover, we revealed the relationship between the synaptic conductance change behavior and the molecular properties of the electrolyte ions. Furthermore, the waveform of the conductance change can be controlled by adjusting the conditions for wire asymmetrization. These results demonstrate that the PEDOT:PSS wire exhibits a synaptic conductance change, yielding a waveform suitable for machine learning, even under wet conditions (i.e., in any electrolyte solution, including PBS). Therefore, PEDOT:PSS wire is a promising material for two-terminal synaptic devices applicable in clinical studies.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	98354
citation_title	PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions
citation_author	Watanabe, Seiya
	Shibakita, Hiroaki
	Hagiwara, Naruki
	Nakajima, Ryosuke
	Kato, Hiroyuki S.
	Akai-Kasaya, Megumi
citation_publisher	American Chemical Society
citation_language	English
citation_date	2024-09-30
citation_journal_title	ACS Applied Materials and Interfaces
citation_volume	16
citation_issue	40
citation_firstpage	54636
citation_lastpage	54644
citation_doi	https://doi.org/10.1021/acsami.4c12037
citation_public_url	https://hdl.handle.net/11094/98354

PEDOT:PSS Wire: A Two-Terminal Synaptic Device for Operation in Electrolyte and Saline Solutions

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