Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy

Tahata, Yuki; Hikita, Hayato; Mochida, Satoshi; Enomoto, Nobuyuki; Kawada, Norifumi; Ido, Akio; Miki, Daiki; Kurosaki, Masayuki; Yoshiji, Hitoshi; Sakamori, Ryotaro; Kuroda, Hidekatsu; Yatsuhashi, Hiroshi; Yamashita, Taro; Hiasa, Yoichi; Kato, Naoya; Miyaaki, Hisamitsu; Ueno, Yoshiyuki; Itoh, Yoshito; Matsuura, Kentaro; Takami, Taro; Asahina, Yasuhiro; Suda, Goki; Akuta, Norio; Tateishi, Ryosuke; Nakamoto, Yasunari; Kakazu, Eiji; Terai, Shuji; Shimizu, Masahito; Miyazaki, Masanori; Nozaki, Yasutoshi; Sobue, Satoshi; Yano, Hiroki; Miyaki, Tomokatsu; Moriuchi, Akihiro; Hori, Takeshi; Shirai, Kumiko; Murai, Kazuhiro; Saito, Yoshinobu; Kodama, Takahiro; Tatsumi, Tomohide; Yamada, Tomomi; Takehara, Tetsuo

doi:https://doi.org/10.1111/hepr.14131

Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy

Tahata, Yuki; Hikita, Hayato; Mochida, Satoshi et al.

Hepatology Research, 2024, 55(3), 319-332

Number of Access:7,627（2025-12-05 11:21 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98412

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Title	Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy
Creator	NRID 1000000838047 1000000838047 researchmap permalink yuki.tahata yuki.tahata Scopus Author ID 56755390400 56755390400 ORCID 0000-0002-9116-7054 0000-0002-9116-7054 CreatorName Tahata, Yuki
	NRID 1000020623044 1000020623044 researchmap permalink hikitahayato hikitahayato Scopus Author ID 23667454900 23667454900 ORCID 0000-0003-2488-7315 0000-0003-2488-7315 CreatorName Hikita, Hayato
	NRID 1000020219968 1000020219968 CreatorName Mochida, Satoshi
	NRID 1000020251530 1000020251530 CreatorName Enomoto, Nobuyuki
	NRID 1000030271191 1000030271191 CreatorName Kawada, Norifumi
	NRID 1000030291545 1000030291545 CreatorName Ido, Akio
	NRID 1000010584592 1000010584592 CreatorName Miki, Daiki
	NRID 1000010280976 1000010280976 CreatorName Kurosaki, Masayuki
	NRID 1000040336855 1000040336855 CreatorName Yoshiji, Hitoshi
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	NRID 1000070382596 1000070382596 CreatorName Kuroda, Hidekatsu
	NRID 1000050360855 1000050360855 CreatorName Yatsuhashi, Hiroshi
	NRID 1000090377432 1000090377432 CreatorName Yamashita, Taro
	NRID 1000070314961 1000070314961 CreatorName Hiasa, Yoichi
	NRID 1000090313220 1000090313220 CreatorName Kato, Naoya
	NRID 1000020437891 1000020437891 CreatorName Miyaaki, Hisamitsu
	NRID 1000070282126 1000070282126 CreatorName Ueno, Yoshiyuki
	NRID 1000070244613 1000070244613 CreatorName Itoh, Yoshito
	NRID 1000030580576 1000030580576 CreatorName Matsuura, Kentaro
	NRID 1000060511251 1000060511251 CreatorName Takami, Taro
	NRID 1000000422692 1000000422692 CreatorName Asahina, Yasuhiro
	NRID 1000020447460 1000020447460 CreatorName Suda, Goki
	NRID 1000020469638 1000020469638 CreatorName Akuta, Norio
	NRID 1000050444089 1000050444089 CreatorName Tateishi, Ryosuke
	NRID 1000040293352 1000040293352 CreatorName Nakamoto, Yasunari
	NRID 1000020509377 1000020509377 CreatorName Kakazu, Eiji
	NRID 1000000332809 1000000332809 CreatorName Terai, Shuji
	NRID 1000090402198 1000090402198 CreatorName Shimizu, Masahito
	CreatorName Miyazaki, Masanori
	CreatorName Nozaki, Yasutoshi
	CreatorName Sobue, Satoshi
	CreatorName Yano, Hiroki
	CreatorName Miyaki, Tomokatsu
	NRID 1000040359823 1000040359823 CreatorName Moriuchi, Akihiro
	NRID 1000000281220 1000000281220 CreatorName Hori, Takeshi
	NRID 1000020992267 1000020992267 researchmap permalink u987841f u987841f CreatorName Shirai, Kumiko
	NRID 1000050867314 1000050867314 ORCID 0000-0001-8634-2922 0000-0001-8634-2922 researchmap permalink murai_kazuhiro murai_kazuhiro Scopus Author ID 57202460806 57202460806 CreatorName Murai, Kazuhiro
	NRID 1000060814598 1000060814598 ORCID 0000-0002-0624-0449 0000-0002-0624-0449 researchmap permalink saito_yoshinobu saito_yoshinobu Scopus Author ID 55912459300 55912459300 CreatorName Saito, Yoshinobu
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	NRID 1000020397699 1000020397699 researchmap permalink read0140669 read0140669 Scopus Author ID 7202112131 7202112131 CreatorName Tatsumi, Tomohide
	NRID 1000060363371 1000060363371 researchmap permalink ymd ymd Scopus Author ID 35254679600 35254679600 CreatorName Yamada, Tomomi
	NRID 1000070335355 1000070335355 researchmap permalink takeharatetsuo takeharatetsuo Scopus Author ID 7103332258 7103332258 CreatorName Takehara, Tetsuo
Subject	DAA
	esophagogastric varix
	HCV
	sustained virologic response
	varix aggravation
	varix rupture
Description	Tahata Y., Hikita H., Mochida S., et al. Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy. Hepatology Research, (2024); https://doi.org/10.1111/hepr.14131.
Abstract	Aim: The incidence of and factors involved in gastroesophageal varix-related events in hepatitis C virus-related cirrhosis patients, including decompensated cirrhosis, after direct-acting antiviral therapy are unclear. Methods: We conducted a multicenter study using prospective data from 478 hepatitis C virus-related cirrhosis patients treated with direct-acting antiviral therapy from February 2019 to December 2021 at 33 Japanese hospitals. Gastroesophageal varices were classified as F1 (small-caliber), F2 (moderately enlarged), or F3 (markedly enlarged) according to the Japanese criteria. Patients without varix or with F1 without red color signs were defined as low-risk varix, and patients with ≥F2 or red color signs or a history of rupture were defined as high-risk varix. Varix-related events were defined as prophylactic treatment or rupture of gastroesophageal varix. Results: The median age was 70 years, 43% of patients had decompensated cirrhosis, and 16% had high-risk varices (13% in compensated and 33% in decompensated, p < 0.001). Sustained virologic response rates were 94.9% for compensated cirrhosis and 91.3% for decompensated cirrhosis (p = 0.120). Across 35.7 months, 25 patients received prophylactic treatment, and four experienced varix rupture. The 3-year incidence rate of varix-related events was 6.2% (3.5% in compensated and 9.9% in decompensated, p = 0.001). In the multivariate analysis, high-risk varix (p < 0.001), high baseline gamma-glutamyl transpeptidase levels (p < 0.001), and virologic failure (p = 0.004) were significantly involved in varix-related events. Conclusions: The cumulative incidence rate of varix-related events was significantly higher in decompensated cirrhosis than in compensated cirrhosis. Baseline varix status, baseline gamma-glutamyl transpeptidase levels, and virologic response were related to varix-related events after direct-acting antiviral therapy.
Publisher	John Wiley and Sons Inc
Source Title	Hepatology Research
Volume (Issue)	55(3)
Page	319-332
Date of Issued	2024-10-29
Language	English
Handle URL	https://hdl.handle.net/11094/98412
PISSN	13866346
eISSN	1872034X
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/hepr.14131
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Hepatology Research. 2024, 55(3), p. 319-332
DC.title	Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy
DC.creator	Tahata, Yuki
	Hikita, Hayato
	Mochida, Satoshi
	Enomoto, Nobuyuki
	Kawada, Norifumi
	Ido, Akio
	Miki, Daiki
	Kurosaki, Masayuki
	Yoshiji, Hitoshi
	Sakamori, Ryotaro
	Kuroda, Hidekatsu
	Yatsuhashi, Hiroshi
	Yamashita, Taro
	Hiasa, Yoichi
	Kato, Naoya
	Miyaaki, Hisamitsu
	Ueno, Yoshiyuki
	Itoh, Yoshito
	Matsuura, Kentaro
	Takami, Taro
	Asahina, Yasuhiro
	Suda, Goki
	Akuta, Norio
	Tateishi, Ryosuke
	Nakamoto, Yasunari
	Kakazu, Eiji
	Terai, Shuji
	Shimizu, Masahito
	Miyazaki, Masanori
	Nozaki, Yasutoshi
	Sobue, Satoshi
	Yano, Hiroki
	Miyaki, Tomokatsu
	Moriuchi, Akihiro
	Hori, Takeshi
	Shirai, Kumiko
	Murai, Kazuhiro
	Saito, Yoshinobu
	Kodama, Takahiro
	Tatsumi, Tomohide
	Yamada, Tomomi
	Takehara, Tetsuo
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-10-29
DC.identifier	https://doi.org/10.1111/hepr.14131
DC.subject	DAA
	esophagogastric varix
	HCV
	sustained virologic response
	varix aggravation
	varix rupture
DC.description	Tahata Y., Hikita H., Mochida S., et al. Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy. Hepatology Research, (2024); https://doi.org/10.1111/hepr.14131.
DCTERMS.abstract	Aim: The incidence of and factors involved in gastroesophageal varix-related events in hepatitis C virus-related cirrhosis patients, including decompensated cirrhosis, after direct-acting antiviral therapy are unclear. Methods: We conducted a multicenter study using prospective data from 478 hepatitis C virus-related cirrhosis patients treated with direct-acting antiviral therapy from February 2019 to December 2021 at 33 Japanese hospitals. Gastroesophageal varices were classified as F1 (small-caliber), F2 (moderately enlarged), or F3 (markedly enlarged) according to the Japanese criteria. Patients without varix or with F1 without red color signs were defined as low-risk varix, and patients with ≥F2 or red color signs or a history of rupture were defined as high-risk varix. Varix-related events were defined as prophylactic treatment or rupture of gastroesophageal varix. Results: The median age was 70 years, 43% of patients had decompensated cirrhosis, and 16% had high-risk varices (13% in compensated and 33% in decompensated, p < 0.001). Sustained virologic response rates were 94.9% for compensated cirrhosis and 91.3% for decompensated cirrhosis (p = 0.120). Across 35.7 months, 25 patients received prophylactic treatment, and four experienced varix rupture. The 3-year incidence rate of varix-related events was 6.2% (3.5% in compensated and 9.9% in decompensated, p = 0.001). In the multivariate analysis, high-risk varix (p < 0.001), high baseline gamma-glutamyl transpeptidase levels (p < 0.001), and virologic failure (p = 0.004) were significantly involved in varix-related events. Conclusions: The cumulative incidence rate of varix-related events was significantly higher in decompensated cirrhosis than in compensated cirrhosis. Baseline varix status, baseline gamma-glutamyl transpeptidase levels, and virologic response were related to varix-related events after direct-acting antiviral therapy.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	98412
citation_title	Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy
citation_author	Tahata, Yuki
	Hikita, Hayato
	Mochida, Satoshi
	Enomoto, Nobuyuki
	Kawada, Norifumi
	Ido, Akio
	Miki, Daiki
	Kurosaki, Masayuki
	Yoshiji, Hitoshi
	Sakamori, Ryotaro
	Kuroda, Hidekatsu
	Yatsuhashi, Hiroshi
	Yamashita, Taro
	Hiasa, Yoichi
	Kato, Naoya
	Miyaaki, Hisamitsu
	Ueno, Yoshiyuki
	Itoh, Yoshito
	Matsuura, Kentaro
	Takami, Taro
	Asahina, Yasuhiro
	Suda, Goki
	Akuta, Norio
	Tateishi, Ryosuke
	Nakamoto, Yasunari
	Kakazu, Eiji
	Terai, Shuji
	Shimizu, Masahito
	Miyazaki, Masanori
	Nozaki, Yasutoshi
	Sobue, Satoshi
	Yano, Hiroki
	Miyaki, Tomokatsu
	Moriuchi, Akihiro
	Hori, Takeshi
	Shirai, Kumiko
	Murai, Kazuhiro
	Saito, Yoshinobu
	Kodama, Takahiro
	Tatsumi, Tomohide
	Yamada, Tomomi
	Takehara, Tetsuo
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2024-10-29
citation_journal_title	Hepatology Research
citation_volume	55
citation_issue	3
citation_firstpage	319
citation_lastpage	332
citation_doi	https://doi.org/10.1111/hepr.14131
citation_public_url	https://hdl.handle.net/11094/98412

Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy

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