Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques

Dong, Dong; Hosomi, Koichi; Shimizu, Takeshi; Okada, Ken-ichi; Kadono, Yoshinori; Mori, Nobuhiko; Hori, Yuki; Yahata, Noriaki; Hirabayashi, Toshiyuki; Kishima, Haruhiko; Saitoh, Youichi

doi:https://doi.org/10.1016/j.jpain.2024.104661

Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques

Dong, Dong; Hosomi, Koichi; Shimizu, Takeshi et al.

Journal of Pain, 2024, 25(12), 104661

Number of Access:1,403（2025-08-14 15:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98457

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Title	Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques
Creator	NRID 1000090864025 1000090864025 researchmap permalink DongDong DongDong CreatorName Dong, Dong
	NRID 1000070533800 1000070533800 researchmap permalink HosomiKoichi HosomiKoichi Scopus Author ID 23967898900 23967898900 ORCID 0000-0001-7731-3302 0000-0001-7731-3302 CreatorName Hosomi, Koichi
	NRID 1000010721102 1000010721102 CreatorName Shimizu, Takeshi
	NRID 1000080790956 1000080790956 CreatorName Okada, Ken-ichi
	NRID 1000060770675 1000060770675 researchmap permalink nsurg-YK nsurg-YK CreatorName Kadono, Yoshinori
	NRID 1000020833924 1000020833924 ORCID 0000-0001-6537-6322 0000-0001-6537-6322 researchmap permalink Mori_Nobuhiko Mori_Nobuhiko CreatorName Mori, Nobuhiko
	NRID 1000060635887 1000060635887 CreatorName Hori, Yuki
	NRID 1000070409150 1000070409150 CreatorName Yahata, Noriaki
	NRID 1000060376423 1000060376423 CreatorName Hirabayashi, Toshiyuki
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
	NRID 1000020252661 1000020252661 researchmap permalink read0076638 read0076638 CreatorName Saitoh, Youichi
Subject	Cross-species
	functional connectivity changes
	human
	macaques
	thalamic pain
Description	Dong D., Hosomi K., Shimizu T., et al. Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques. Journal of Pain 25, 104661 (2024); https://doi.org/10.1016/j.jpain.2024.104661.
Abstract	Thalamic pain can be understood as a network reorganization disorder. This study aimed to investigate functional connectivity (FC) in human patients and a macaque model of thalamic pain. In humans, resting-state FC was compared between patients with thalamic pain and healthy individuals. Furthermore, resting-state FC was compared in macaques, before and after the induction of thalamic pain in the same individuals. FC between the amygdala of the unaffected hemisphere and the brainstem was significantly higher in patients with thalamic pain. More specifically, a significantly higher FC was observed between the basolateral amygdala and the ventral tegmental area, which also significantly predicted the value of a visual analog scale of pain intensity in individual patients. The macaque model of thalamic pain also exhibited a significantly higher FC between the amygdala of the unaffected hemisphere and the brainstem, particularly between the basolateral amygdala and the midbrain. Furthermore, the previously reported significantly higher FC between the amygdala and the mediodorsal nucleus of the thalamus in macaques with thalamic pain was also reproduced in the human patients. Therefore, the present results suggest that the FC changes in the regions associated with emotion, memory, motivation, and reward are part of the underlying mechanisms of thalamic pain onset present in both human patients and model macaques. This cross-species convergence provides new insights into the neurological mechanisms underlying thalamic pain, paving the way for further studies and the development of therapeutic strategies.
Publisher	Elsevier B.V.
Source Title	Journal of Pain
Volume (Issue)	25(12)
Page	104661
Date of Issued	2024-12-01
Language	English
Handle URL	https://hdl.handle.net/11094/98457
PISSN	15265900
eISSN	15288447
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.jpain.2024.104661
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Journal of Pain. 2024, 25(12), p. 104661
DC.title	Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques
DC.creator	Dong, Dong
	Hosomi, Koichi
	Shimizu, Takeshi
	Okada, Ken-ichi
	Kadono, Yoshinori
	Mori, Nobuhiko
	Hori, Yuki
	Yahata, Noriaki
	Hirabayashi, Toshiyuki
	Kishima, Haruhiko
	Saitoh, Youichi
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-01
DC.identifier	https://doi.org/10.1016/j.jpain.2024.104661
DC.subject	Cross-species
	functional connectivity changes
	human
	macaques
	thalamic pain
DC.description	Dong D., Hosomi K., Shimizu T., et al. Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques. Journal of Pain 25, 104661 (2024); https://doi.org/10.1016/j.jpain.2024.104661.
DCTERMS.abstract	Thalamic pain can be understood as a network reorganization disorder. This study aimed to investigate functional connectivity (FC) in human patients and a macaque model of thalamic pain. In humans, resting-state FC was compared between patients with thalamic pain and healthy individuals. Furthermore, resting-state FC was compared in macaques, before and after the induction of thalamic pain in the same individuals. FC between the amygdala of the unaffected hemisphere and the brainstem was significantly higher in patients with thalamic pain. More specifically, a significantly higher FC was observed between the basolateral amygdala and the ventral tegmental area, which also significantly predicted the value of a visual analog scale of pain intensity in individual patients. The macaque model of thalamic pain also exhibited a significantly higher FC between the amygdala of the unaffected hemisphere and the brainstem, particularly between the basolateral amygdala and the midbrain. Furthermore, the previously reported significantly higher FC between the amygdala and the mediodorsal nucleus of the thalamus in macaques with thalamic pain was also reproduced in the human patients. Therefore, the present results suggest that the FC changes in the regions associated with emotion, memory, motivation, and reward are part of the underlying mechanisms of thalamic pain onset present in both human patients and model macaques. This cross-species convergence provides new insights into the neurological mechanisms underlying thalamic pain, paving the way for further studies and the development of therapeutic strategies.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	98457
citation_title	Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques
citation_author	Dong, Dong
	Hosomi, Koichi
	Shimizu, Takeshi
	Okada, Ken-ichi
	Kadono, Yoshinori
	Mori, Nobuhiko
	Hori, Yuki
	Yahata, Noriaki
	Hirabayashi, Toshiyuki
	Kishima, Haruhiko
	Saitoh, Youichi
citation_publisher	Elsevier B.V.
citation_language	English
citation_date	2024-12-01
citation_journal_title	Journal of Pain
citation_volume	25
citation_issue	12
citation_firstpage	104661
citation_doi	https://doi.org/10.1016/j.jpain.2024.104661
citation_public_url	https://hdl.handle.net/11094/98457

Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques

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