Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation

Chimura, Misato; Ohtani, Tomohito; Sera, Fusako; Nakamoto, Kei; Akazawa, Yasuhiro; Kajitani, Kenji; Higuchi, Rie; Kagiya, Toshifumi; Sakata, Yasushi

doi:https://doi.org/10.1016/j.ijcard.2024.132596

Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation

Chimura, Misato; Ohtani, Tomohito; Sera, Fusako et al.

International Journal of Cardiology, 2025, 418, 132596

Number of Access:46（2025-04-30 13:29 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98581

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Title	Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation
Creator	NRID 1000080815506 1000080815506 researchmap permalink mstcmr mstcmr Scopus Author ID 56203376800 56203376800 CreatorName Chimura, Misato
	NRID 1000030623897 1000030623897 researchmap permalink tohtani tohtani Scopus Author ID 57932819800 57932819800 CreatorName Ohtani, Tomohito
	NRID 1000070794139 1000070794139 ORCID 0000-0002-9260-6901 0000-0002-9260-6901 researchmap permalink fsera fsera Scopus Author ID 57196563132 57196563132 CreatorName Sera, Fusako
	CreatorName Nakamoto, Kei
	NRID 1000080882266 1000080882266 researchmap permalink y-akzw y-akzw Scopus Author ID 36096360000 36096360000 CreatorName Akazawa, Yasuhiro
	CreatorName Kajitani, Kenji
	CreatorName Higuchi, Rie
	CreatorName Kagiya, Toshifumi
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	Ascending aortic diameter
	Left ventricular assist device
	Pulmonary artery diameter
	Right ventricular failure
Description	Chimura M., Ohtani T., Sera F., et al. Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation. International Journal of Cardiology 418, 132596 (2025); https://doi.org/10.1016/j.ijcard.2024.132596.
Abstract	Background: Several invasive hemodynamic parameters help predict right ventricular failure (RVF) after left ventricular assist device (LVAD) implantation. However, prediction using non-invasive parameters alone has not been established. The ratio of the diameters of the pulmonary artery (PAD) to those of the ascending aorta (AoD) may indicate past hemodynamic load and cardiac dysfunction. We aimed to investigate a predictive model for RVF after LVAD implantation using non-invasive parameters including PAD/AoD ratio. Methods: We studied 141 patients who underwent primary LVAD implantation and 117 healthy individuals with computed tomography (CT) data. RVF was defined as the need for a subsequent right ventricular assist device or intravenous inotrope administration for more than 30 days after LVAD implantation. The PAD/AoD ratio was measured at the level of the pulmonary artery bifurcation on the CT transaxial slices. Results: RVF was observed in 29 patients. The correlation between PAD and AoD differed among healthy individuals, patients with and without RVF. Patients with RVF had higher total bilirubin and log brain natriuretic peptide (BNP) levels, a lower left ventricular end-diastolic diameter (LVDd) index, and a higher PAD/AoD ratio than those without RVF. Decision tree analysis indicated that the subgroup with a high PAD/AoD ratio (≥1.09) and a small LVDd index (<35.4 mm/m2) showed the highest probability of RVF (100 %), while the subgroup with a low PAD/AoD ratio (<1.09) and low log BNP (<2.79) showed the lowest probability of RVF (1 %). Conclusion: Combining non-invasive parameters with the PAD/AoD ratio can predict RVF with high accuracy.
Publisher	Elsevier Ireland Ltd
Source Title	International Journal of Cardiology
Volume (Issue)	418
Page	132596
Date of Issued	2025-01-01
Language	English
Handle URL	https://hdl.handle.net/11094/98581
PISSN	01675273
eISSN	18741754
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.ijcard.2024.132596
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	International Journal of Cardiology. 2025, 418, p. 132596
DC.title	Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation
DC.creator	Chimura, Misato
	Ohtani, Tomohito
	Sera, Fusako
	Nakamoto, Kei
	Akazawa, Yasuhiro
	Kajitani, Kenji
	Higuchi, Rie
	Kagiya, Toshifumi
	Sakata, Yasushi
DC.publisher	Elsevier Ireland Ltd
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-01-01
DC.identifier	https://doi.org/10.1016/j.ijcard.2024.132596
DC.subject	Ascending aortic diameter
	Left ventricular assist device
	Pulmonary artery diameter
	Right ventricular failure
DC.description	Chimura M., Ohtani T., Sera F., et al. Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation. International Journal of Cardiology 418, 132596 (2025); https://doi.org/10.1016/j.ijcard.2024.132596.
DCTERMS.abstract	Background: Several invasive hemodynamic parameters help predict right ventricular failure (RVF) after left ventricular assist device (LVAD) implantation. However, prediction using non-invasive parameters alone has not been established. The ratio of the diameters of the pulmonary artery (PAD) to those of the ascending aorta (AoD) may indicate past hemodynamic load and cardiac dysfunction. We aimed to investigate a predictive model for RVF after LVAD implantation using non-invasive parameters including PAD/AoD ratio. Methods: We studied 141 patients who underwent primary LVAD implantation and 117 healthy individuals with computed tomography (CT) data. RVF was defined as the need for a subsequent right ventricular assist device or intravenous inotrope administration for more than 30 days after LVAD implantation. The PAD/AoD ratio was measured at the level of the pulmonary artery bifurcation on the CT transaxial slices. Results: RVF was observed in 29 patients. The correlation between PAD and AoD differed among healthy individuals, patients with and without RVF. Patients with RVF had higher total bilirubin and log brain natriuretic peptide (BNP) levels, a lower left ventricular end-diastolic diameter (LVDd) index, and a higher PAD/AoD ratio than those without RVF. Decision tree analysis indicated that the subgroup with a high PAD/AoD ratio (≥1.09) and a small LVDd index (<35.4 mm/m2) showed the highest probability of RVF (100 %), while the subgroup with a low PAD/AoD ratio (<1.09) and low log BNP (<2.79) showed the lowest probability of RVF (1 %). Conclusion: Combining non-invasive parameters with the PAD/AoD ratio can predict RVF with high accuracy.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	98581
citation_title	Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation
citation_author	Chimura, Misato
	Ohtani, Tomohito
	Sera, Fusako
	Nakamoto, Kei
	Akazawa, Yasuhiro
	Kajitani, Kenji
	Higuchi, Rie
	Kagiya, Toshifumi
	Sakata, Yasushi
citation_publisher	Elsevier Ireland Ltd
citation_language	English
citation_date	2025-01-01
citation_journal_title	International Journal of Cardiology
citation_volume	418
citation_firstpage	132596
citation_doi	https://doi.org/10.1016/j.ijcard.2024.132596
citation_public_url	https://hdl.handle.net/11094/98581

Ratio of pulmonary artery diameter to ascending aortic diameter and its association with right ventricular failure after left ventricular assist device implantation

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