Calvarial Thickening in Tuberous Sclerosis Complex

Kuroda, Hideki; Khoo, Hui Ming; Fujita, Yuya; Tominaga, Koji; Kagitani-Shimono, Kuriko; Hosomi, Koichi; Tani, Naoki; Oshino, Satoru; Wataya-Kaneda, Mari; Kishima, Haruhiko

doi:https://doi.org/10.1016/j.wneu.2024.09.130

Calvarial Thickening in Tuberous Sclerosis Complex

Kuroda, Hideki; Khoo, Hui Ming; Fujita, Yuya et al.

World Neurosurgery, 2024, 192, e460-e467

Number of Access:143（2025-05-21 14:04 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98594

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Title	Calvarial Thickening in Tuberous Sclerosis Complex
Creator	researchmap permalink kurodahideki kurodahideki CreatorName Kuroda, Hideki
	NRID 1000070591022 1000070591022 ORCID 0000-0002-4039-0520 0000-0002-4039-0520 researchmap permalink hmkhoo hmkhoo Scopus Author ID 55314143200 55314143200 CreatorName Khoo, Hui Ming
	CreatorName Fujita, Yuya
	CreatorName Tominaga, Koji
	NRID 1000060403185 1000060403185 ORCID 0000-0001-9649-9499 0000-0001-9649-9499 researchmap permalink osaka_rengo osaka_rengo Scopus Author ID 13002542100 13002542100 CreatorName Kagitani-Shimono, Kuriko
	NRID 1000070533800 1000070533800 researchmap permalink HosomiKoichi HosomiKoichi Scopus Author ID 23967898900 23967898900 ORCID 0000-0001-7731-3302 0000-0001-7731-3302 CreatorName Hosomi, Koichi
	NRID 1000020598370 1000020598370 researchmap permalink n_taniOsakaUniv n_taniOsakaUniv Scopus Author ID 7103335692 7103335692 CreatorName Tani, Naoki
	NRID 1000040403050 1000040403050 ORCID 0000-0002-4248-2322 0000-0002-4248-2322 researchmap permalink handai_ns_oshino handai_ns_oshino Scopus Author ID 6602717325 6602717325 CreatorName Oshino, Satoru
	NRID 1000070397644 1000070397644 researchmap permalink 3031 3031 Scopus Author ID 6602902401 6602902401 CreatorName Wataya-Kaneda, Mari
	NRID 1000010332743 1000010332743 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 CreatorName Kishima, Haruhiko
Subject	Craniotomy
	Skull thickening
	Tuberous sclerosis complex
Description	Kuroda H., Khoo H.M., Fujita Y., et al. Calvarial Thickening in Tuberous Sclerosis Complex. World Neurosurgery 192, e460 (2024); https://doi.org/10.1016/j.wneu.2024.09.130.
Abstract	Background: Tuberous sclerosis complex (TSC)–related skeletal abnormalities are understudied. Awareness of skull thickening in patients with TSC is important from the surgical standpoint because a thick skull might complicate craniotomy. This study aimed to discover if patients with TSC are generally prone to skull thickening by retrospectively investigating the frequency and characteristics of skull thickening in these patients. Methods: Patients with TSC ages 10 to 60 years who underwent magnetic resonance imaging in the neurosurgery, dermatology, or pediatrics clinic between 2010 and 2021 were identified. Two control groups were used for comparison: one with patients with unruptured intracranial aneurysms to serve as control without antiseizure medication exposure and one with non-TSC epilepsy as control with antiseizure medication exposure. In all patients, thickness of frontal, parietal, temporal, and occipital bones was measured at a fixed location of each bone on T2-weighted axial images. Results: Inclusion criteria were fulfilled by 29 patients. Frontal and temporal bones of the TSC group were significantly thicker than those of either control group. Skull thickening was significantly associated with intracerebral calcification, but not with age, sex, or antiseizure medication exposure. Focal skull thickening was associated with the presence of a subcortical calcification. Conclusions: Patients with TSC have skull thickening, which is often linked to intracerebral calcification. The presence of skull thickening may require modification of surgical approach during craniotomy. Skull thickening and the underlying intracerebral calcification likely share a common precipitating factor given their relationship. Future studies are warranted to clarify the genetic underpinnings of this relationship and even broader skeletal abnormalities in TSC.
Publisher	Elsevier Inc.
Source Title	World Neurosurgery
Volume (Issue)	192
Page	e460-e467
Date of Issued	2024-12-01
Language	English
Handle URL	https://hdl.handle.net/11094/98594
PISSN	18788750
eISSN	18788769
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.wneu.2024.09.130
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	World Neurosurgery. 2024, 192, p. e460-e467
DC.title	Calvarial Thickening in Tuberous Sclerosis Complex
DC.creator	Kuroda, Hideki
	Khoo, Hui Ming
	Fujita, Yuya
	Tominaga, Koji
	Kagitani-Shimono, Kuriko
	Hosomi, Koichi
	Tani, Naoki
	Oshino, Satoru
	Wataya-Kaneda, Mari
	Kishima, Haruhiko
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-12-01
DC.identifier	https://doi.org/10.1016/j.wneu.2024.09.130
DC.subject	Craniotomy
	Skull thickening
	Tuberous sclerosis complex
DC.description	Kuroda H., Khoo H.M., Fujita Y., et al. Calvarial Thickening in Tuberous Sclerosis Complex. World Neurosurgery 192, e460 (2024); https://doi.org/10.1016/j.wneu.2024.09.130.
DCTERMS.abstract	Background: Tuberous sclerosis complex (TSC)–related skeletal abnormalities are understudied. Awareness of skull thickening in patients with TSC is important from the surgical standpoint because a thick skull might complicate craniotomy. This study aimed to discover if patients with TSC are generally prone to skull thickening by retrospectively investigating the frequency and characteristics of skull thickening in these patients. Methods: Patients with TSC ages 10 to 60 years who underwent magnetic resonance imaging in the neurosurgery, dermatology, or pediatrics clinic between 2010 and 2021 were identified. Two control groups were used for comparison: one with patients with unruptured intracranial aneurysms to serve as control without antiseizure medication exposure and one with non-TSC epilepsy as control with antiseizure medication exposure. In all patients, thickness of frontal, parietal, temporal, and occipital bones was measured at a fixed location of each bone on T2-weighted axial images. Results: Inclusion criteria were fulfilled by 29 patients. Frontal and temporal bones of the TSC group were significantly thicker than those of either control group. Skull thickening was significantly associated with intracerebral calcification, but not with age, sex, or antiseizure medication exposure. Focal skull thickening was associated with the presence of a subcortical calcification. Conclusions: Patients with TSC have skull thickening, which is often linked to intracerebral calcification. The presence of skull thickening may require modification of surgical approach during craniotomy. Skull thickening and the underlying intracerebral calcification likely share a common precipitating factor given their relationship. Future studies are warranted to clarify the genetic underpinnings of this relationship and even broader skeletal abnormalities in TSC.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	98594
citation_title	Calvarial Thickening in Tuberous Sclerosis Complex
citation_author	Kuroda, Hideki
	Khoo, Hui Ming
	Fujita, Yuya
	Tominaga, Koji
	Kagitani-Shimono, Kuriko
	Hosomi, Koichi
	Tani, Naoki
	Oshino, Satoru
	Wataya-Kaneda, Mari
	Kishima, Haruhiko
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2024-12-01
citation_journal_title	World Neurosurgery
citation_volume	192
citation_firstpage	e460
citation_lastpage	e467
citation_doi	https://doi.org/10.1016/j.wneu.2024.09.130
citation_public_url	https://hdl.handle.net/11094/98594

Calvarial Thickening in Tuberous Sclerosis Complex

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