Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study

Hamamoto, Yuichiro; Kido, Kansuke; Kawamura, Michihiro et al.

Pathology - Research and Practice, 2024, 264, 155682

Number of Access:869（2025-10-27 22:02 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98597

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Title
Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study
Creator
ORCID
0000-0002-3511-760X 0000-0002-3511-760X
researchmap permalink
yhama yhama
Scopus Author ID
57210885924 57210885924
CreatorName
Hamamoto, Yuichiro
researchmap permalink
kansukekido kansukekido
CreatorName
Kido, Kansuke
CreatorName
Kawamura, Michihiro
NRID
1000000781709 1000000781709
researchmap permalink
00781709 00781709
Scopus Author ID
57193691322 57193691322
ORCID
0000-0003-4281-0047 0000-0003-4281-0047
CreatorName
Sekido, Yuki
NRID
1000050597458 1000050597458
researchmap permalink
togino04 togino04
Scopus Author ID
57200254430 57200254430
ORCID
0000-0001-5435-4144 0000-0001-5435-4144
CreatorName
Ogino, Takayuki
CreatorName
Yasuoka, Hironao
NRID
1000090444520 1000090444520
researchmap permalink
_0719 _0719
CreatorName
Iijima, Hideki
NRID
1000000527707 1000000527707
CreatorName
Mizushima, Tsunekazu
Subject
amyloid
inflammatory bowel disease
Crohn's disease
ulcerative colitis
Description
Hamamoto Y., Kido K., Kawamura M., et al. Subclinical amyloid deposition in inflammatory bowel diseases: A two hospital study. Pathology - Research and Practice 264, 155682 (2024); https://doi.org/10.1016/j.prp.2024.155682.
Abstract
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), predominantly affects young patients and leads to intestinal complications. Amyloidosis, which involves abnormal protein deposition, is a serious complication of IBD, with a low incidence. Early detection of subclinical amyloid deposits is crucial for preventing fatal outcomes; however, routine investigations are lacking. We aimed to retrospectively examine subclinical amyloid deposition in adult patients with IBD. Surgical specimens from 249 patients with IBD were collected from the databases of two hospitals. The specimens were subjected to staining and immunohistochemistry, and clinical information was collected simultaneously. The amyloid positivity rate was 0.8 % in CD (1/131) and 0 % in UC (0/118) based on Congo red staining. The patient with amyloid deposits was a female in her 80 s who lacked a family history of amyloidosis. The subtype was amyloid A. Clinical history revealed intestinal resection in her 30 s and subsequent abdominal symptoms. To the best of our knowledge, this is the first study to collect >100 surgically examined specimens from adults with CD or UC. In older patients with a long and complex clinical course, aggressive analysis of amyloids would be better.
Publisher
Elsevier BV
Source Title
Pathology - Research and Practice
Volume (Issue)
264
Page
155682
Date of Issued
2024-12-01
Language
English
Handle URL
https://hdl.handle.net/11094/98597
PISSN
03440338
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.prp.2024.155682
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article