Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases

Hamamoto, Yuichiro; Kawamura, Michihiro; Uchida, Hiroki et al.

Applied Immunohistochemistry and Molecular Morphology, 2023, 31(2), 107-112

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Identifier to cite or link to this item: https://hdl.handle.net/11094/98832

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Title
Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases
Creator
ORCID
0000-0002-3511-760X 0000-0002-3511-760X
researchmap permalink
yhama yhama
Scopus Author ID
57210885924 57210885924
CreatorName
Hamamoto, Yuichiro
CreatorName
Kawamura, Michihiro
CreatorName
Uchida, Hiroki
CreatorName
Takagahara, Kojiro
CreatorName
Katori, Chiaki
CreatorName
Asai, Hinako
CreatorName
Harada, Hiroshi
NRID
1000030336672 1000030336672
CreatorName
Shimizu, Shigeki
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
CreatorName
Morii, Eiichi
CreatorName
Yoshida, Kyotaro
Subject
crohn disease
immunohistochemistry
inflammatory bowel disease
ischemic colitis
MUC
mucin
ulcerative colitis
Description
This is a non-final version of an article published in final form in Hamamoto Y., Kawamura M., Uchida H., et al. Aberrant MUC Immunohistochemical Expressions in Inflammatory Bowel Diseases. Applied Immunohistochemistry and Molecular Morphology 31, 107 (2023); https://doi.org/10.1097/pai.0000000000001096.
Abstract
Ulcerative colitis (UC) and Crohn disease (CD) are cryptogenic inflammatory bowel diseases that are suggestive of aberrant mucin (MUC) expression; however, their relationship remains unclear. Here, we examined aberrant MUC expression in intestinal samples from UC and CD patients in comparison to samples from patients with ischemic colitis and control groups. To study the expression of MUC1, MUC5AC, and MUC6 in different patient groups, we reviewed the slides stained with hematoxylin and eosin and performed immunohistochemistry. The results revealed that MUC1 was expressed more in the UC group and MUC6 in the CD group. No significant changes were observed in MUC expression in the ischemic colitis group. Overall, we demonstrated changes in MUC expression in UC and CD, which can help in the diagnosis and early clinical management of UC and CD.
Publisher
Lippincott Williams and Wilkins
Source Title
Applied Immunohistochemistry and Molecular Morphology
Volume (Issue)
31(2)
Page
107-112
Date of Issued
2023-02-01
Language
English
Handle URL
https://hdl.handle.net/11094/98832
PISSN
15412016
eISSN
15334058
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1097/pai.0000000000001096
Access Rights
open access
CopyRight
© 2022 Lippincott Williams and Wilkins
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article