Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland

Hamamoto, Yuichiro; Harada, Hiroshi; Kohara, Masaharu et al.

Medical Molecular Morphology, 2021, 54(1), 23-30

Number of Access:183（2025-06-07 18:33 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98834

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Title
Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland
Creator
ORCID
0000-0002-3511-760X 0000-0002-3511-760X
researchmap permalink
yhama yhama
Scopus Author ID
57210885924 57210885924
CreatorName
Hamamoto, Yuichiro
CreatorName
Harada, Hiroshi
ORCID
0009-0006-7636-5833 0009-0006-7636-5833
CreatorName
Kohara, Masaharu
NRID
1000020505945 1000020505945
CreatorName
Honma, Keiichiro
NRID
1000090303940 1000090303940
CreatorName
Nakatsuka, Shin-ichi
NRID
1000010283772 1000010283772
ORCID
0000-0001-8490-3650 0000-0001-8490-3650
researchmap permalink
read0046454 read0046454
Scopus Author ID
7003914326 7003914326
CreatorName
Morii, Eiichi
Subject
Acinic cell carcinoma
ETV6-NTRK3
Phosphorylated signal transducer and activator of transcription 5
Salivary gland
Secretory carcinoma
Description
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00795-020-00256-4.
Abstract
Secretory carcinoma (SC) of the salivary gland is a relatively newly described disease, separate from acinic cell carcinoma (ACC), which frequently displays ETV6-NTRK3 gene fusion. However, the differences between SC and ACC remain unclear. Here, histological reevaluation of 12 formerly diagnosed ACC cases was performed, which yielded a new diagnosis of SC in four cases due to a lack of obvious acinar-like cells. Immunohistochemically, phosphorylated signal transducer and activator of transcription 5 (p-STAT5) was expressed in SC but not in ACC, whereas discovered on GIST-1 (DOG1) was expressed in ACC but not in SC. Molecular analysis was possible in three SC cases, of which two showed the ETV6-NTRK3 fusion transcript on reverse-transcription polymerase chain reaction, as well as breaks in the ETV6 gene on fluorescence in situ hybridization. However, the remaining SC cases did not show this fusion transcript. Recently, several reports have suggested that SC might not be adequately diagnosed if the focus is placed solely on the ETV6-NTRK3 fusion gene due to genetic diversity. In this regard, immunohistochemistry of p-STAT5 and DOG1 is expected to be a useful alternative diagnostic tool to discriminate SC from ACC.
Publisher
Springer
Source Title
Medical Molecular Morphology
Volume (Issue)
54(1)
Page
23-30
Date of Issued
2021-03-01
Language
English
Handle URL
https://hdl.handle.net/11094/98834
PISSN
18601480
eISSN
18601499
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1007/s00795-020-00256-4
Access Rights
open access
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article