Recent advances in noncoding RNA modifications of gastrointestinal cancer

Hara, Tomoaki; Meng, Sikun; Arao, Yasuko et al.

Cancer Science, 2024, 116(1), 8-20

Number of Access:1,038（2025-08-14 15:06 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/98884

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Title
Recent advances in noncoding RNA modifications of gastrointestinal cancer
Creator
NRID
1000030779161 1000030779161
researchmap permalink
registered20221012 registered20221012
CreatorName
Hara, Tomoaki
NRID
1000050977204 1000050977204
researchmap permalink
sikunmeng sikunmeng
CreatorName
Meng, Sikun
NRID
1000070962736 1000070962736
CreatorName
Arao, Yasuko
CreatorName
Saito, Yoshiko
CreatorName
Inoue, Kana
CreatorName
Rennie, Sarah
CreatorName
Ofusa, Ken
NRID
1000020291445 1000020291445
researchmap permalink
ydoki3251 ydoki3251
Scopus Author ID
7006390687 7006390687
CreatorName
Doki, Yuichiro
NRID
1000090542118 1000090542118
researchmap permalink
abcdabcdabcd abcdabcdabcd
Scopus Author ID
7101627772 7101627772
CreatorName
Eguchi, Hidetoshi
NRID
1000040314322 1000040314322
researchmap permalink
torumd torumd
CreatorName
Kitagawa, Toru
NRID
1000010280736 1000010280736
researchmap permalink
read0103186 read0103186
Scopus Author ID
7402978600 7402978600
CreatorName
Ishii, Hideshi
Subject
circRNA
gastrointestinal cancer
lncRNA
miRNA
RNA modifications
Description
Hara T., Meng S., Arao Y., et al. Recent advances in noncoding RNA modifications of gastrointestinal cancer. Cancer Science, (2024); https://doi.org/10.1111/cas.16380.
Abstract
Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6-methyladenosine (m⁶A) has been performed by many research groups, with multiple studies reporting that m⁶A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m⁶A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.
Publisher
John Wiley and Sons Inc
Source Title
Cancer Science
Volume (Issue)
116(1)
Page
8-20
Date of Issued
2024-11-01
Language
English
Handle URL
https://hdl.handle.net/11094/98884
PISSN
13479032
eISSN
13497006
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1111/cas.16380
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article