Blood DNA virome associates with autoimmune diseases and COVID-19

Sasa, Noah; Kojima, Shohei; Koide, Rie et al.

Nature Genetics, 2025

Number of Access:717（2025-07-31 08:16 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/99693

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Title
Blood DNA virome associates with autoimmune diseases and COVID-19
Creator
NRID
1000090882241 1000090882241
researchmap permalink
nsasa nsasa
CreatorName
Sasa, Noah
NRID
1000030851703 1000030851703
CreatorName
Kojima, Shohei
NRID
1000040846325 1000040846325
CreatorName
Koide, Rie
NRID
1000080753756 1000080753756
CreatorName
Hasegawa, Takanori
NRID
1000050594644 1000050594644
CreatorName
Namkoong, Ho
NRID
1000070727411 1000070727411
ORCID
0000-0002-0311-8472 0000-0002-0311-8472
researchmap permalink
yokada yokada
Scopus Author ID
7005443464 7005443464
CreatorName
Okada, Yukinori
Description
A list of all authors and their affiliations appears at the end of the paper.
Sasa Noah, Kojima Shohei, Koide Rie, et al. Blood DNA virome associates with autoimmune diseases and COVID-19. Nature Genetics 11, 197 (2025); https://doi.org/10.1038/s41588-024-02022-z.
Abstract
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus. Participants with eHHV-6B had higher risks of SLE and PAP; the former was validated in All of Us. eHHV-6B-positivity and high SLE disease activity index scores had strong correlations. Genome-wide association study and long-read sequencing mapped the integration of the HHV-6B genome to a locus on chromosome 22q. Epitope mapping and single-cell RNA sequencing revealed distinctive immune induction by eHHV-6B in patients with SLE. In addition, high anellovirus load correlated strongly with SLE, RA and COVID-19 status. Our analyses unveil relationships between the human virome and autoimmune and infectious diseases.
Publisher
Springer Science and Business Media LLC
Source Title
Nature Genetics
Date of Issued
2025-01-03
Language
English
Handle URL
https://hdl.handle.net/11094/99693
PISSN
10614036
eISSN
15461718
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1038/s41588-024-02022-z
Access Rights
open access
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This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Category
学術雑誌論文 Journal Article