Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery

Hosokawa, Kiyohito; Takenaka, Yukinori; Sato, Takashi; Tsuda, Takeshi; Eguchi, Hirotaka; Suzuki, Masami; Kitamura, Koji; Fukusumi, Takahito; Suzuki, Motoyuki; Inohara, Hidenori

doi:https://doi.org/10.1371/journal.pone.0312455

Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery

Hosokawa, Kiyohito; Takenaka, Yukinori; Sato, Takashi et al.

PLoS ONE, 2024, 19(10), e0312455

Number of Access:1,625（2025-08-14 00:37 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/99701

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Title	Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery
Creator	NRID 1000060625896 1000060625896 researchmap permalink drink drink Scopus Author ID 55914870000 55914870000 ORCID 0000-0002-5169-1038 0000-0002-5169-1038 CreatorName Hosokawa, Kiyohito
	NRID 1000040598398 1000040598398 ORCID 0000-0002-3135-5635 0000-0002-3135-5635 researchmap permalink yukinoritakenaka yukinoritakenaka Scopus Author ID 7102054128 7102054128 CreatorName Takenaka, Yukinori
	NRID 1000030756002 1000030756002 researchmap permalink 4501 4501 Scopus Author ID 7406982585 7406982585 CreatorName Sato, Takashi
	NRID 1000000778631 1000000778631 researchmap permalink gam92471 gam92471 CreatorName Tsuda, Takeshi
	researchmap permalink eguchi-hirotaka eguchi-hirotaka Scopus Author ID 57203344374 57203344374 CreatorName Eguchi, Hirotaka
	NRID 1000080434182 1000080434182 researchmap permalink msuzukicgi msuzukicgi Scopus Author ID 57199980789 57199980789 CreatorName Suzuki, Masami
	NRID 1000040804365 1000040804365 researchmap permalink kitamura1009 kitamura1009 CreatorName Kitamura, Koji
	NRID 1000070623734 1000070623734 researchmap permalink 2933 2933 Scopus Author ID 54893429600 54893429600 ORCID 0009-0002-1857-7548 0009-0002-1857-7548 CreatorName Fukusumi, Takahito
	NRID 1000050632329 1000050632329 researchmap permalink motoyukisuzuki motoyukisuzuki Scopus Author ID 55505806400 55505806400 CreatorName Suzuki, Motoyuki
	NRID 1000000273657 1000000273657 researchmap permalink read0046473 read0046473 Scopus Author ID 7004501837 7004501837 CreatorName Inohara, Hidenori
Description	Hosokawa K et al. (2024) Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery. PLoS ONE 19(10): e0312455. doi: 10.1371/journal.pone.0312455.
Abstract	Background: Head and neck small-cell carcinoma (HNSmCC) is a rare and aggressive cancer with a high tendency for distant metastasis. It is treated with multimodal treatment involving chemotherapy. Occasionally, surgery is performed for the management of locoregional HNSmCC. However, the benefits of surgery in this context have not yet been elucidated. Therefore, in this study, we aimed to investigate whether surgery could improve the survival of patients with HNSmCC. Patients and methods: We obtained data from patients with locoregional HNSmCC treated with chemoradiation therapy (CRT) from the Surveillance, Epidemiology, and End Results database. Patients who did and did not undergo surgery were matched using propensity scores. The overall survival (OS) and disease-specific survival (DSS) rates were estimated using the Kaplan-Meier method and tested using the log-rank test. Hazard ratios (HRs) were calculated using the Cox proportional hazard model. Results: The 5-year OS rates of the patients who did and did not undergo surgery were 57.2% and 50.6%, respectively (P = 0.689); the corresponding 5-year DSS rates were 61.0% and 57.5% (P = 0.769). The adjusted HRs for surgery were 0.85 (95% confidence interval [CI]: 0.54–1.33) for OS and 0.87 (95% CI: 0.51–1.49) for DSS. Conclusion: The addition of surgery to CRT did not improve the survival of patients with locoregional HNSmCC.
Publisher	Public Library of Science
Source Title	PLoS ONE
Volume (Issue)	19(10)
Page	e0312455
Date of Issued	2024-10-24
Language	English
Handle URL	https://hdl.handle.net/11094/99701
eISSN	19326203
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1371/journal.pone.0312455
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	PLoS ONE. 2024, 19(10), p. e0312455
DC.title	Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery
DC.creator	Hosokawa, Kiyohito
	Takenaka, Yukinori
	Sato, Takashi
	Tsuda, Takeshi
	Eguchi, Hirotaka
	Suzuki, Masami
	Kitamura, Koji
	Fukusumi, Takahito
	Suzuki, Motoyuki
	Inohara, Hidenori
DC.publisher	Public Library of Science
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-10-24
DC.identifier	https://doi.org/10.1371/journal.pone.0312455
DC.description	Hosokawa K et al. (2024) Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery. PLoS ONE 19(10): e0312455. doi: 10.1371/journal.pone.0312455.
DCTERMS.abstract	Background: Head and neck small-cell carcinoma (HNSmCC) is a rare and aggressive cancer with a high tendency for distant metastasis. It is treated with multimodal treatment involving chemotherapy. Occasionally, surgery is performed for the management of locoregional HNSmCC. However, the benefits of surgery in this context have not yet been elucidated. Therefore, in this study, we aimed to investigate whether surgery could improve the survival of patients with HNSmCC. Patients and methods: We obtained data from patients with locoregional HNSmCC treated with chemoradiation therapy (CRT) from the Surveillance, Epidemiology, and End Results database. Patients who did and did not undergo surgery were matched using propensity scores. The overall survival (OS) and disease-specific survival (DSS) rates were estimated using the Kaplan-Meier method and tested using the log-rank test. Hazard ratios (HRs) were calculated using the Cox proportional hazard model. Results: The 5-year OS rates of the patients who did and did not undergo surgery were 57.2% and 50.6%, respectively (P = 0.689); the corresponding 5-year DSS rates were 61.0% and 57.5% (P = 0.769). The adjusted HRs for surgery were 0.85 (95% confidence interval [CI]: 0.54–1.33) for OS and 0.87 (95% CI: 0.51–1.49) for DSS. Conclusion: The addition of surgery to CRT did not improve the survival of patients with locoregional HNSmCC.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	99701
citation_title	Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery
citation_author	Hosokawa, Kiyohito
	Takenaka, Yukinori
	Sato, Takashi
	Tsuda, Takeshi
	Eguchi, Hirotaka
	Suzuki, Masami
	Kitamura, Koji
	Fukusumi, Takahito
	Suzuki, Motoyuki
	Inohara, Hidenori
citation_publisher	Public Library of Science
citation_language	English
citation_date	2024-10-24
citation_journal_title	PLoS ONE
citation_volume	19
citation_issue	10
citation_firstpage	e0312455
citation_doi	https://doi.org/10.1371/journal.pone.0312455
citation_public_url	https://hdl.handle.net/11094/99701

Small-cell carcinoma in the head and neck region: A propensity score-matched analysis of the effect of surgery

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