Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia

Chen, Wei; Oue, Takaharu; Ueno, Takehisa et al.

Pediatric Surgery International, 2013, 29, 79-85

Number of Access:537（2025-07-22 21:52 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/99832

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Title
Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia
Creator
CreatorName
Chen, Wei
NRID
1000050314315 1000050314315
CreatorName
Oue, Takaharu
NRID
1000010456957 1000010456957
ORCID
0000-0002-4639-8814 0000-0002-4639-8814
researchmap permalink
ueno-pedsurg ueno-pedsurg
Scopus Author ID
21743992300 21743992300
CreatorName
Ueno, Takehisa
NRID
1000000448060 1000000448060
CreatorName
Uehara, Shuichiro
NRID
1000030273626 1000030273626
researchmap permalink
read0194004 read0194004
CreatorName
Usui, Noriaki
NRID
1000060165272 1000060165272
researchmap permalink
read0106298 read0106298
CreatorName
Fukuzawa, Masahiro
Subject
Apelin
APJ
Biliary atresia
Esophageal varices
Liver fibrosis
Liver transplantation
Description
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00383-012-3210-7
Abstract
Purpose: Apelin, the endogenous ligand of the angiotensin-like-receptor 1 (APJ), is thought to play an important role in liver disease. This study investigated the apelin expression in different stages of biliary atresia (BA) and investigated whether it is associated with the progression of disease. Methods: Liver tissues were obtained from patients at Kasai's procedure (KP), the follow-up stage after KP (Post-KP) and at liver transplantation (LT). Immunohistochemistry for apelin and its receptor APJ and real-time quantitative reverse transcriptase polymerase chain reaction for apelin mRNA expression were conducted. Results: The immunohistochemical study revealed that apelin was mainly localized in the perivenular areas of control liver tissue, and slightly detected in the hepatic stellate cells (HSC) and hepatocytes, whereas intense apelin immunoreactivity was detected in perivenular areas, HSC and hepatocytes of LT liver tissue. The apelin mRNA expression level was significantly higher in the LT group than in the KP and Post-KP group. Significant linear correlations were observed between the apelin mRNA level and liver fibrosis, serum total bilirubin and the grade of esophageal varices. Conclusions: The hepatic apelin-APJ system is markedly activated in the progression of BA, especially in end-stage cirrhosis. The apelin expression level accurately reflects the severity of hepatic fibrosis and esophageal varices and therefore could be used as a prognostic factor in BA patients.
Publisher
Springer Science and Business Media Deutschland GmbH
Source Title
Pediatric Surgery International
Volume (Issue)
29
Page
79-85
Date of Issued
2013-01-01
Language
English
Handle URL
https://hdl.handle.net/11094/99832
PISSN
01790358
eISSN
14379813
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1007/s00383-012-3210-7
Access Rights
open access
CopyRight
© 2012 Springer-Verlag Berlin Heidelberg
oaire:version
Accepted Manuscript
Category
会議発表論文 Conference Paper