Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report

Takase, Koki; Ueno, Takehisa; Yamamichi, Taku; Iwasaki, Shun; Toyama, Chiyoshi; Okada, Yosuke; Nomura, Motonari; Watanabe, Miho; Sawada, Akihisa; Miyamura, Takako; Bessho, Kazuhiko; Inoue, Masami; Usui, Noriaki; Okuyama, Hiroomi

doi:https://doi.org/10.1016/j.transproceed.2021.12.037

Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report

Takase, Koki; Ueno, Takehisa; Yamamichi, Taku et al.

Transplantation Proceedings, 2022, 54(2), 556-559

Number of Access:1,643（2026-02-18 06:30 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/99837

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Title	Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report
Creator	NRID 1000080961763 1000080961763 CreatorName Takase, Koki
	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 CreatorName Ueno, Takehisa
	NRID 1000030715165 1000030715165 CreatorName Yamamichi, Taku
	NRID 1000040882254 1000040882254 researchmap permalink 123qwe 123qwe CreatorName Iwasaki, Shun
	NRID 1000010839369 1000010839369 CreatorName Toyama, Chiyoshi
	CreatorName Okada, Yosuke
	NRID 1000040546909 1000040546909 researchmap permalink moto_pedsurg moto_pedsurg Scopus Author ID 35208741700 35208741700 ORCID 0009-0004-0959-7461 0009-0004-0959-7461 CreatorName Nomura, Motonari
	NRID 1000040791728 1000040791728 researchmap permalink miho miho Scopus Author ID 56282966800 56282966800 ORCID 0000-0001-6691-0611 0000-0001-6691-0611 CreatorName Watanabe, Miho
	CreatorName Sawada, Akihisa
	NRID 1000020379796 1000020379796 researchmap permalink 19710329 19710329 Scopus Author ID 7101873379 7101873379 CreatorName Miyamura, Takako
	NRID 1000080423169 1000080423169 researchmap permalink KazuBe KazuBe CreatorName Bessho, Kazuhiko
	NRID 1000030565354 1000030565354 CreatorName Inoue, Masami
	NRID 1000030273626 1000030273626 researchmap permalink read0194004 read0194004 CreatorName Usui, Noriaki
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X CreatorName Okuyama, Hiroomi
Description	Takase K., Ueno T., Yamamichi T., et al. Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report. Transplantation Proceedings 54, 556 (2022); https://doi.org/10.1016/j.transproceed.2021.12.037.
Abstract	Background: Liver transplantation (LTx) is indicated for unresectable hepatoblastoma (HB) without distal metastasis. However, to our knowledge, there is no consensus on the management of unresectable HB with pulmonary metastases, or on the treatment of recurrent HB. We report a successful case of metastatic HB treated with repeated lung resection, chemotherapy, and LTx. This study strictly complied with the Helsinki Congress and the Istanbul Declaration regarding donor source. Case Report: Our case was a 1-year-old boy who developed pre-treatment extent of disease (PRETEXT) Ⅲ HB with multiple pulmonary metastases. The liver tumor was unresectable because it involved all hepatic veins. After 3 cycles of chemotherapy (cisplatin/carboplatin plus doxorubicin), the remaining 2 pulmonary metastases were resected and living donor liver transplantation (LDLT) was performed. Five months after LDLT, a tumor recurrence was detected in the right lung. Repeat lung resection was performed followed by 1 cycle of chemotherapy (carboplatin plus doxorubicin). There has been no recurrence for 18 months since the last lung resection. Discussion: Previous reports revealed that 14 patients, including the present case, underwent LTx after resection of metastatic HB pulmonary lesions. Of these patients, the 2-year survival rate after LTx was 91%. Recurrence was reported in 5 patients, 2 of whom were successfully treated with repeated resection of the metastatic lesions. LTx after resection of lung recurrence may be a potential treatment for unresectable HB with pulmonary metastases.
Publisher	Elsevier Inc.
Source Title	Transplantation Proceedings
Volume (Issue)	54(2)
Page	556-559
Date of Issued	2022-03-01
Language	English
Handle URL	https://hdl.handle.net/11094/99837
PISSN	00411345
eISSN	18732623
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1016/j.transproceed.2021.12.037
Access Rights	open access
CopyRight	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Transplantation Proceedings. 2022, 54(2), p. 556-559
DC.title	Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report
DC.creator	Takase, Koki
	Ueno, Takehisa
	Yamamichi, Taku
	Iwasaki, Shun
	Toyama, Chiyoshi
	Okada, Yosuke
	Nomura, Motonari
	Watanabe, Miho
	Sawada, Akihisa
	Miyamura, Takako
	Bessho, Kazuhiko
	Inoue, Masami
	Usui, Noriaki
	Okuyama, Hiroomi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-03-01
DC.identifier	https://doi.org/10.1016/j.transproceed.2021.12.037
DC.description	Takase K., Ueno T., Yamamichi T., et al. Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report. Transplantation Proceedings 54, 556 (2022); https://doi.org/10.1016/j.transproceed.2021.12.037.
DCTERMS.abstract	Background: Liver transplantation (LTx) is indicated for unresectable hepatoblastoma (HB) without distal metastasis. However, to our knowledge, there is no consensus on the management of unresectable HB with pulmonary metastases, or on the treatment of recurrent HB. We report a successful case of metastatic HB treated with repeated lung resection, chemotherapy, and LTx. This study strictly complied with the Helsinki Congress and the Istanbul Declaration regarding donor source. Case Report: Our case was a 1-year-old boy who developed pre-treatment extent of disease (PRETEXT) Ⅲ HB with multiple pulmonary metastases. The liver tumor was unresectable because it involved all hepatic veins. After 3 cycles of chemotherapy (cisplatin/carboplatin plus doxorubicin), the remaining 2 pulmonary metastases were resected and living donor liver transplantation (LDLT) was performed. Five months after LDLT, a tumor recurrence was detected in the right lung. Repeat lung resection was performed followed by 1 cycle of chemotherapy (carboplatin plus doxorubicin). There has been no recurrence for 18 months since the last lung resection. Discussion: Previous reports revealed that 14 patients, including the present case, underwent LTx after resection of metastatic HB pulmonary lesions. Of these patients, the 2-year survival rate after LTx was 91%. Recurrence was reported in 5 patients, 2 of whom were successfully treated with repeated resection of the metastatic lesions. LTx after resection of lung recurrence may be a potential treatment for unresectable HB with pulmonary metastases.
DC.rights	© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	99837
citation_title	Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report
citation_author	Takase, Koki
	Ueno, Takehisa
	Yamamichi, Taku
	Iwasaki, Shun
	Toyama, Chiyoshi
	Okada, Yosuke
	Nomura, Motonari
	Watanabe, Miho
	Sawada, Akihisa
	Miyamura, Takako
	Bessho, Kazuhiko
	Inoue, Masami
	Usui, Noriaki
	Okuyama, Hiroomi
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2022-03-01
citation_journal_title	Transplantation Proceedings
citation_volume	54
citation_issue	2
citation_firstpage	556
citation_lastpage	559
citation_doi	https://doi.org/10.1016/j.transproceed.2021.12.037
citation_public_url	https://hdl.handle.net/11094/99837

Successful Surgical Resection and Chemotherapy for Unresectable Hepatoblastoma With Pulmonary Metastases and for Lung Recurrence After Liver Transplantation: A Case Report

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