Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia

Takase, Koki; Ueno, Takehisa; Matsuki, Kyoko; Todo, Marie; Iwasaki, Shun; Deguchi, Koihi; Masahata, Kazunori; Nomura, Motonari; Watanabe, Miho; Kamiyama, Masafumi; Tazuke, Yuko; Kimura, Takeshi; Okuyama, Hiroomi

doi:https://doi.org/10.1016/j.transproceed.2023.03.026

Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia

Takase, Koki; Ueno, Takehisa; Matsuki, Kyoko et al.

Transplantation Proceedings, 2023, 55(4), 872-877

Number of Access:127（2025-05-29 14:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/99838

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Title	Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia
Creator	NRID 1000080961763 1000080961763 CreatorName Takase, Koki
	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 CreatorName Ueno, Takehisa
	NRID 1000000961765 1000000961765 researchmap permalink kokon kokon CreatorName Matsuki, Kyoko
	NRID 1000050882239 1000050882239 CreatorName Todo, Marie
	NRID 1000040882254 1000040882254 CreatorName Iwasaki, Shun
	NRID 1000000747082 1000000747082 researchmap permalink deguchi_koichi deguchi_koichi Scopus Author ID 57139781700 57139781700 CreatorName Deguchi, Koihi
	NRID 1000040588381 1000040588381 CreatorName Masahata, Kazunori
	NRID 1000040546909 1000040546909 researchmap permalink moto_pedsurg moto_pedsurg Scopus Author ID 35208741700 35208741700 ORCID 0009-0004-0959-7461 0009-0004-0959-7461 CreatorName Nomura, Motonari
	NRID 1000040791728 1000040791728 researchmap permalink miho miho Scopus Author ID 56282966800 56282966800 ORCID 0000-0001-6691-0611 0000-0001-6691-0611 CreatorName Watanabe, Miho
	NRID 1000020403074 1000020403074 researchmap permalink kamiyamapedsurg kamiyamapedsurg Scopus Author ID 55559187300 55559187300 CreatorName Kamiyama, Masafumi
	NRID 1000010397698 1000010397698 researchmap permalink yukotazuke-osaka yukotazuke-osaka Scopus Author ID 7006109798 7006109798 ORCID 0000-0002-8335-0414 0000-0002-8335-0414 CreatorName Tazuke, Yuko
	NRID 1000050774402 1000050774402 researchmap permalink kimutake kimutake Scopus Author ID 57205488897 57205488897 CreatorName Kimura, Takeshi
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X CreatorName Okuyama, Hiroomi
Description	Takase K., Ueno T., Matsuki K., et al. Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia. Transplantation Proceedings 55, 872 (2023); https://doi.org/10.1016/j.transproceed.2023.03.026.
Abstract	Background: The appropriate timing of liver transplantation (LT) in patients with biliary atresia (BA) who survived with their native livers until adolescence remains controversial. The liver–spleen volume ratio (LSR) has been reported to be efficacious in predicting the prognosis of chronic liver disease. We investigated whether LSR could predict long-term native liver prognosis and serve as an indication for LT in patients with BA. Methods: Patients with BA who survived with their native liver until the age of 15 years were included. These patients were classified into 2 groups. The unfavorable prognosis group included patients who underwent or were awaiting LT or developed complications such as refractory cholangitis or gastrointestinal bleeding due to esophagogastric or intestinal varices. The favorable prognosis group included patients who survived with their native liver without complications. We compared the 2 groups regarding LSR, hematological, and histologic data. Results: Of 19 patients, 8 were in the unfavorable prognosis group, and 11 were in the favorable prognosis group. LSR was significantly lower in the unfavorable prognosis group (P = .009). Analysis of the receiver operating characteristic curve showed that the area under the curve of the LSR was 0.891, which was higher than the area under the curve of liver fibrosis markers. The optimal LSR cut-off value for predicting poor native liver prognosis was 1.97, with a sensitivity of 75.0% and a specificity of 87.5%. Conclusions: The LSR reflects splenomegaly and liver atrophy. The LSR might be a reliable predictor of native liver prognosis and could guide decisions about LT in patients with BA.
Publisher	Elsevier Inc.
Source Title	Transplantation Proceedings
Volume (Issue)	55(4)
Page	872-877
Date of Issued	2023-05-01
Language	English
Handle URL	https://hdl.handle.net/11094/99838
PISSN	00411345
eISSN	18732623
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1016/j.transproceed.2023.03.026
Access Rights	open access
CopyRight	© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Transplantation Proceedings. 2023, 55(4), p. 872-877
DC.title	Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia
DC.creator	Takase, Koki
	Ueno, Takehisa
	Matsuki, Kyoko
	Todo, Marie
	Iwasaki, Shun
	Deguchi, Koihi
	Masahata, Kazunori
	Nomura, Motonari
	Watanabe, Miho
	Kamiyama, Masafumi
	Tazuke, Yuko
	Kimura, Takeshi
	Okuyama, Hiroomi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2023-05-01
DC.identifier	https://doi.org/10.1016/j.transproceed.2023.03.026
DC.description	Takase K., Ueno T., Matsuki K., et al. Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia. Transplantation Proceedings 55, 872 (2023); https://doi.org/10.1016/j.transproceed.2023.03.026.
DCTERMS.abstract	Background: The appropriate timing of liver transplantation (LT) in patients with biliary atresia (BA) who survived with their native livers until adolescence remains controversial. The liver–spleen volume ratio (LSR) has been reported to be efficacious in predicting the prognosis of chronic liver disease. We investigated whether LSR could predict long-term native liver prognosis and serve as an indication for LT in patients with BA. Methods: Patients with BA who survived with their native liver until the age of 15 years were included. These patients were classified into 2 groups. The unfavorable prognosis group included patients who underwent or were awaiting LT or developed complications such as refractory cholangitis or gastrointestinal bleeding due to esophagogastric or intestinal varices. The favorable prognosis group included patients who survived with their native liver without complications. We compared the 2 groups regarding LSR, hematological, and histologic data. Results: Of 19 patients, 8 were in the unfavorable prognosis group, and 11 were in the favorable prognosis group. LSR was significantly lower in the unfavorable prognosis group (P = .009). Analysis of the receiver operating characteristic curve showed that the area under the curve of the LSR was 0.891, which was higher than the area under the curve of liver fibrosis markers. The optimal LSR cut-off value for predicting poor native liver prognosis was 1.97, with a sensitivity of 75.0% and a specificity of 87.5%. Conclusions: The LSR reflects splenomegaly and liver atrophy. The LSR might be a reliable predictor of native liver prognosis and could guide decisions about LT in patients with BA.
DC.rights	© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	99838
citation_title	Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia
citation_author	Takase, Koki
	Ueno, Takehisa
	Matsuki, Kyoko
	Todo, Marie
	Iwasaki, Shun
	Deguchi, Koihi
	Masahata, Kazunori
	Nomura, Motonari
	Watanabe, Miho
	Kamiyama, Masafumi
	Tazuke, Yuko
	Kimura, Takeshi
	Okuyama, Hiroomi
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2023-05-01
citation_journal_title	Transplantation Proceedings
citation_volume	55
citation_issue	4
citation_firstpage	872
citation_lastpage	877
citation_doi	https://doi.org/10.1016/j.transproceed.2023.03.026
citation_public_url	https://hdl.handle.net/11094/99838

Liver-Spleen Volume Ratio as a Predictor of Native Liver Survival in Patients with Biliary Atresia

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