Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report

Deguchi, K.; Ueno, T.; Matsuura, R.; Yamanaka, H.; Nara, K.; Uehara, S.; Tazuke, Y.; Bessho, K.; Okuyama, H.

doi:https://doi.org/10.1016/J.TRANSPROCEED.2015.12.033

Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report

Deguchi, K.; Ueno, T.; Matsuura, R. et al.

Transplantation Proceedings, 2016, 48(1), 251-254

Number of Access:1,054（2025-07-22 21:57 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100146

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Title	Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report
Creator	NRID 1000000747082 1000000747082 researchmap permalink deguchi_koichi deguchi_koichi Scopus Author ID 57139781700 57139781700 CreatorName Deguchi, K.
	NRID 1000010456957 1000010456957 ORCID 0000-0002-4639-8814 0000-0002-4639-8814 researchmap permalink ueno-pedsurg ueno-pedsurg Scopus Author ID 21743992300 21743992300 CreatorName Ueno, T.
	NRID 1000000747412 1000000747412 CreatorName Matsuura, R.
	NRID 1000070467570 1000070467570 CreatorName Yamanaka, H.
	NRID 1000000432477 1000000432477 CreatorName Nara, K.
	NRID 1000000448060 1000000448060 CreatorName Uehara, S.
	NRID 1000010397698 1000010397698 researchmap permalink yukotazuke-osaka yukotazuke-osaka Scopus Author ID 7006109798 7006109798 ORCID 0000-0002-8335-0414 0000-0002-8335-0414 CreatorName Tazuke, Y.
	NRID 1000080423169 1000080423169 researchmap permalink KazuBe KazuBe CreatorName Bessho, K.
	NRID 1000030252670 1000030252670 researchmap permalink okuyamahiroomi okuyamahiroomi Scopus Author ID 35496082300 35496082300 ORCID 0000-0002-1347-282X 0000-0002-1347-282X CreatorName Okuyama, H.
Description	Deguchi K., Ueno T., Matsuura R., et al. Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report. Transplantation Proceedings 48, 251 (2016); https://doi.org/10.1016/J.TRANSPROCEED.2015.12.033.
Abstract	Background: Hypercalcemia has been observed in patients after liver transplantation. However, it is rare that the hypercalcemia induced disseminated tissue calcification and heart failure. Case Report: We report a rare case of heart failure caused by disseminated metastatic tissue calcification that involved extensive progressive myocardial calcification after liver transplantation. A 20-year-old man with end-stage liver disease due to biliary atresia underwent ABO-incompatible living donor liver transplantation. After successful transplantation, he suffered from antibody-mediated rejection. Subsequently, ABO-matched cadaveric liver retransplantation was successfully performed. Hypercalcemia developed gradually following the second transplantation. His serum calcium level increased to 18.3 mg/dL with sudden onset of ventricular tachycardia. Although he was resuscitated with a cardiopulmonary support device, he died of heart and liver failure. Histopathologic examination revealed systemic disseminated metastatic tissue calcification, including massive myocardial calcification. Conclusion: Progressive worsening of hypercalcemia resulted in disseminated metastatic tissue calcification and massive metastatic myocardial calcification, which led to heart failure after liver transplantation. Because hypercalcemia after liver transplantation can cause fatal tissue calcification, early intervention for hypercalcemia should be considered.
Publisher	Elsevier USA
Source Title	Transplantation Proceedings
Volume (Issue)	48(1)
Page	251-254
Date of Issued	2016-01-01
Language	English
Handle URL	https://hdl.handle.net/11094/100146
PISSN	00411345
eISSN	18732623
Relation.isVersionOf	DOI (Publisher Version) https://doi.org/10.1016/J.TRANSPROCEED.2015.12.033
Access Rights	open access
CopyRight	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
oaire:version	Accepted Manuscript
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCTERMS.bibliographicCitation	Transplantation Proceedings. 2016, 48(1), p. 251-254
DC.title	Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report
DC.creator	Deguchi, K.
	Ueno, T.
	Matsuura, R.
	Yamanaka, H.
	Nara, K.
	Uehara, S.
	Tazuke, Y.
	Bessho, K.
	Okuyama, H.
DC.publisher	Elsevier USA
DC.language' scheme='DCTERMS.RFC1766	English
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2016-01-01
DC.identifier	https://doi.org/10.1016/J.TRANSPROCEED.2015.12.033
DC.description	Deguchi K., Ueno T., Matsuura R., et al. Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report. Transplantation Proceedings 48, 251 (2016); https://doi.org/10.1016/J.TRANSPROCEED.2015.12.033.
DCTERMS.abstract	Background: Hypercalcemia has been observed in patients after liver transplantation. However, it is rare that the hypercalcemia induced disseminated tissue calcification and heart failure. Case Report: We report a rare case of heart failure caused by disseminated metastatic tissue calcification that involved extensive progressive myocardial calcification after liver transplantation. A 20-year-old man with end-stage liver disease due to biliary atresia underwent ABO-incompatible living donor liver transplantation. After successful transplantation, he suffered from antibody-mediated rejection. Subsequently, ABO-matched cadaveric liver retransplantation was successfully performed. Hypercalcemia developed gradually following the second transplantation. His serum calcium level increased to 18.3 mg/dL with sudden onset of ventricular tachycardia. Although he was resuscitated with a cardiopulmonary support device, he died of heart and liver failure. Histopathologic examination revealed systemic disseminated metastatic tissue calcification, including massive myocardial calcification. Conclusion: Progressive worsening of hypercalcemia resulted in disseminated metastatic tissue calcification and massive metastatic myocardial calcification, which led to heart failure after liver transplantation. Because hypercalcemia after liver transplantation can cause fatal tissue calcification, early intervention for hypercalcemia should be considered.
DC.rights	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.format	100146
citation_title	Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report
citation_author	Deguchi, K.
	Ueno, T.
	Matsuura, R.
	Yamanaka, H.
	Nara, K.
	Uehara, S.
	Tazuke, Y.
	Bessho, K.
	Okuyama, H.
citation_publisher	Elsevier USA
citation_language	English
citation_date	2016-01-01
citation_journal_title	Transplantation Proceedings
citation_volume	48
citation_issue	1
citation_firstpage	251
citation_lastpage	254
citation_doi	https://doi.org/10.1016/J.TRANSPROCEED.2015.12.033
citation_public_url	https://hdl.handle.net/11094/100146

Disseminated metastatic tissue calcification after orthotopic liver transplantation: A case report

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