piRNA processing within non-membrane structures is governed by constituent proteins and their functional motifs

Suyama, Ritsuko; Kai, Toshie

FEBS Journal, 2024

Number of Access:361（2025-09-05 10:57 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/100194

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Title
piRNA processing within non-membrane structures is governed by constituent proteins and their functional motifs
Creator
NRID
1000030574652 1000030574652
ORCID
0000-0001-6154-208X 0000-0001-6154-208X
researchmap permalink
rsuyama rsuyama
CreatorName
Suyama, Ritsuko
NRID
1000040579786 1000040579786
ORCID
0000-0001-8675-8469 0000-0001-8675-8469
researchmap permalink
toshie_kai toshie_kai
Scopus Author ID
7102037941 7102037941
CreatorName
Kai, Toshie
Subject
Drosophila germline
liquid–liquid phase separation
non-membrane nuage
piRNAs
Tudor domain-containing proteins
Description
Suyama R., Kai T. piRNA processing within non-membrane structures is governed by constituent proteins and their functional motifs. FEBS Journal , (2024); https://doi.org/10.1111/febs.17360.
Abstract
Discovered two decades ago, PIWI-interacting RNAs (piRNAs) are crucial for silencing transposable elements (TEs) in animal gonads, thereby protecting the germline genome from harmful transposition, and ensuring species continuity. Silencing of TEs is achieved through transcriptional and post-transcriptional suppression by piRNAs and the PIWI clade of Argonaute proteins within non-membrane structured organelle. These structures are composed of proteins involved in piRNA processing, including PIWIs and other proteins by distinct functional motifs such as the Tudor domain, LOTUS, and intrinsic disordered regions (IDRs). This review highlights recent advances in understanding the roles of these conserved proteins and structural motifs in piRNA biogenesis. We explore the molecular mechanisms of piRNA biogenesis, with a primary focus on Drosophila as a model organism, identifying common themes and species-specific variations. Additionally, we extend the discussion to the roles of these components in nongonadal tissues.
Publisher
John Wiley and Sons Inc
Source Title
FEBS Journal
Date of Issued
2024-12-30
Language
English
Handle URL
https://hdl.handle.net/11094/100194
PISSN
1742464X
eISSN
17424658
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1111/febs.17360
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article