Four-dimensional flow magnetic resonance imaging assessment of left ventricular hemodynamics in transplanted hearts with good postoperative course

Otani, Tomohiro; Ide, Seiko; Mashitani, Yuya et al.

Medical Engineering and Physics, 2025, 142, 104373

Number of Access:65（2025-11-19 01:33 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102609

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Title
Four-dimensional flow magnetic resonance imaging assessment of left ventricular hemodynamics in transplanted hearts with good postoperative course
Creator
NRID
1000040778990 1000040778990
ORCID
0000-0002-6431-2703 0000-0002-6431-2703
researchmap permalink
bigvalley bigvalley
Scopus Author ID
55625962900 55625962900
CreatorName
Otani, Tomohiro
NRID
1000090624247 1000090624247
researchmap permalink
seiko_osaka seiko_osaka
CreatorName
Ide, Seiko
CreatorName
Mashitani, Yuya
NRID
1000000397671 1000000397671
ORCID
0000-0002-5618-4721 0000-0002-5618-4721
researchmap permalink
C4589 C4589
Scopus Author ID
35395964700 35395964700
CreatorName
Sakata, Yasushi
NRID
1000070240546 1000070240546
researchmap permalink
shigeo41010 shigeo41010
Scopus Author ID
7401983636 7401983636
CreatorName
Wada, Shigeo
Subject
4D flow MRI
Flow kinetic energy
Heart transplantation
Hemodynamics
Left ventricle
Description
Otani T., Ide S., Mashitani Y., et al. Four-dimensional flow magnetic resonance imaging assessment of left ventricular hemodynamics in transplanted hearts with good postoperative course. Medical Engineering and Physics 142, 104373 (2025); https://doi.org/10.1016/j.medengphy.2025.104373.
Abstract
Heart transplantation (HTx) is an established treatment for patients with advanced heart failure, although postoperative rejection responses hamper favorable long-term treatment outcomes. Medical imaging is a non-invasive diagnostic modality that can provide attractive insights into cardiac physiology for HTx, including morphological characteristics and cardiac hemodynamics. This study aimed to achieve a basic understanding of left ventricular (LV) hemodynamics in patients with good treatment outcomes following HTx. Specifically, four-dimensional magnetic resonance imaging was performed on 10 patients with a good postoperative course following HTx and 24 controls without a prior history of heart diseases nor HTx. LV hemodynamics were evaluated from the LV flow kinetic energy. We found that LV volumetric functions and kinetic energy ranges were not significantly different between the HTx and control groups, supporting good efficacy of HTx. Nevertheless, a temporal increase in the kinetic energy in late diastole owing to atrial contraction was present in the control group but absent in the HTx group except for one HTx patient. These findings raise the need of further evaluation of cardiac hemodynamics and the pathophysiology of HTx patients even within normal ranges of volumetric and flow transport functions.
Publisher
Elsevier Ltd
Source Title
Medical Engineering and Physics
Volume (Issue)
142
Page
104373
Date of Issued
2025-06-06
Language
English
Handle URL
https://hdl.handle.net/11094/102609
PISSN
13504533
eISSN
18734030
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1016/j.medengphy.2025.104373
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version
Version of Record
Category
学術雑誌論文 Journal Article