Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms

Fukuda, Tatsumaru; Takagaki, Masatoshi; Kaimori, Junya; Motooka, Daisuke; Nakamura, Shota; Kawabata, Shuhei; Nakamura, Hajime; Ozaki, Tomohiko; Nakagawa, Ryota; Matsumura, Takaki; Teranishi, Kunimasa; Yamazaki, Hiroki; Isaka, Yoshitaka; Kishima, Haruhiko

doi:https://doi.org/10.1038/s41598-025-08942-y

Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms

Fukuda, Tatsumaru; Takagaki, Masatoshi; Kaimori, Junya et al.

Scientific Reports, 2025, 15(1), 24204

Number of Access:22（2025-11-24 11:08 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102913

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Title	Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms
Creator	CreatorName Fukuda, Tatsumaru
	NRID 1000070724433 1000070724433 researchmap permalink osakansmt osakansmt Scopus Author ID 46261664000 46261664000 CreatorName Takagaki, Masatoshi
	NRID 1000070527697 1000070527697 researchmap permalink read0191136 read0191136 Scopus Author ID 6506748754 6506748754 CreatorName Kaimori, Junya
	NRID 1000010636830 1000010636830 researchmap permalink daisukem daisukem Scopus Author ID 35315737900 35315737900 CreatorName Motooka, Daisuke
	NRID 1000090432434 1000090432434 ORCID 0000-0003-2058-5942 0000-0003-2058-5942 researchmap permalink nkmrshota nkmrshota Scopus Author ID 35315778200 35315778200 CreatorName Nakamura, Shota
	NRID 1000020764062 1000020764062 CreatorName Kawabata, Shuhei
	NRID 1000080533794 1000080533794 researchmap permalink hnns-osaka hnns-osaka Scopus Author ID 55624478238 55624478238 CreatorName Nakamura, Hajime
	NRID 1000000723123 1000000723123 ORCID 0000-0003-1558-4785 0000-0003-1558-4785 researchmap permalink tomohikoozaki tomohikoozaki Scopus Author ID 56985206300 56985206300 CreatorName Ozaki, Tomohiko
	NRID 1000050889920 1000050889920 researchmap permalink r-nakagawa r-nakagawa Scopus Author ID 57998446000 57998446000 CreatorName Nakagawa, Ryota
	NRID 1000080966755 1000080966755 Scopus Author ID 59341372800 59341372800 CreatorName Matsumura, Takaki
	NRID 1000061002837 1000061002837 Scopus Author ID 58147626500 58147626500 CreatorName Teranishi, Kunimasa
	NRID 1000030995890 1000030995890 Scopus Author ID 57221289104 57221289104 CreatorName Yamazaki, Hiroki
	NRID 1000000379166 1000000379166 ORCID 0000-0002-0820-7167 0000-0002-0820-7167 researchmap permalink isaka-handai3857 isaka-handai3857 Scopus Author ID 16207611100 16207611100 CreatorName Isaka, Yoshitaka
	NRID 1000010332743 1000010332743 ORCID 0000-0002-9041-2337 0000-0002-9041-2337 researchmap permalink hkishima hkishima Scopus Author ID 6603783358 6603783358 CreatorName Kishima, Haruhiko
Subject	Autosomal dominant polycystic kidney
	Gut microbiome
	Intracranial aneurysm
Description	Fukuda T., Takagaki M., Kaimori J., et al. Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms. Scientific Reports 15, 24204 (2025); https://doi.org/10.1038/s41598-025-08942-y.
Abstract	Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by cyst formation in the kidneys, and is associated with an elevated risk of intracranial aneurysms (IAs). Although a family history is a recognized risk factor for IAs in patients with ADPKD, emerging research suggests that gut microbiome composition may influence IA development. We investigated the relationship between the gut microbiome and the development of IA in patients with ADPKD. We recruited patients with ADPKD with (IA group) and without (non-IA group) IA from Osaka University between October 2021 and December 2023. Fecal samples were analyzed using 16S rRNA sequencing. Data were processed using the QIIME 2 pipeline to determine microbial diversity and composition. We included 60 patients: 26 in the IA and 34 in the non-IA groups. There were significant differences in microbial beta diversity between the groups. The IA group had higher abundances of Eubacterium siraeum group, Oscillibacter, Fournierella, Negativibacillus, Colidextribacter, and Adlercreutzia. The non-IA group had higher abundances of Bifidobacterium, Megamonas, Acidaminococcus, Megasphaera, and Merdibacter. There was a significant association between the gut microbiome composition and the presence of IAs in patients with ADPKD. Specific bacterial taxa were differentially abundant between patients with ADPKD with and without IAs, suggesting a potential role of the gut microbiome in the pathogenesis of IAs in this genetically predisposed population.
Publisher	Nature Research
Source Title	Scientific Reports
Volume (Issue)	15(1)
Page	24204
Date of Issued	2025-07-07
Language	English
Handle URL	https://hdl.handle.net/11094/102913
eISSN	20452322
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1038/s41598-025-08942-y
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Scientific Reports. 2025, 15(1), p. 24204
DC.title	Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms
DC.creator	Fukuda, Tatsumaru
	Takagaki, Masatoshi
	Kaimori, Junya
	Motooka, Daisuke
	Nakamura, Shota
	Kawabata, Shuhei
	Nakamura, Hajime
	Ozaki, Tomohiko
	Nakagawa, Ryota
	Matsumura, Takaki
	Teranishi, Kunimasa
	Yamazaki, Hiroki
	Isaka, Yoshitaka
	Kishima, Haruhiko
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-07-07
DC.identifier	https://doi.org/10.1038/s41598-025-08942-y
DC.subject	Autosomal dominant polycystic kidney
	Gut microbiome
	Intracranial aneurysm
DC.description	Fukuda T., Takagaki M., Kaimori J., et al. Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms. Scientific Reports 15, 24204 (2025); https://doi.org/10.1038/s41598-025-08942-y.
DCTERMS.abstract	Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by cyst formation in the kidneys, and is associated with an elevated risk of intracranial aneurysms (IAs). Although a family history is a recognized risk factor for IAs in patients with ADPKD, emerging research suggests that gut microbiome composition may influence IA development. We investigated the relationship between the gut microbiome and the development of IA in patients with ADPKD. We recruited patients with ADPKD with (IA group) and without (non-IA group) IA from Osaka University between October 2021 and December 2023. Fecal samples were analyzed using 16S rRNA sequencing. Data were processed using the QIIME 2 pipeline to determine microbial diversity and composition. We included 60 patients: 26 in the IA and 34 in the non-IA groups. There were significant differences in microbial beta diversity between the groups. The IA group had higher abundances of Eubacterium siraeum group, Oscillibacter, Fournierella, Negativibacillus, Colidextribacter, and Adlercreutzia. The non-IA group had higher abundances of Bifidobacterium, Megamonas, Acidaminococcus, Megasphaera, and Merdibacter. There was a significant association between the gut microbiome composition and the presence of IAs in patients with ADPKD. Specific bacterial taxa were differentially abundant between patients with ADPKD with and without IAs, suggesting a potential role of the gut microbiome in the pathogenesis of IAs in this genetically predisposed population.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	102913
citation_title	Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms
citation_author	Fukuda, Tatsumaru
	Takagaki, Masatoshi
	Kaimori, Junya
	Motooka, Daisuke
	Nakamura, Shota
	Kawabata, Shuhei
	Nakamura, Hajime
	Ozaki, Tomohiko
	Nakagawa, Ryota
	Matsumura, Takaki
	Teranishi, Kunimasa
	Yamazaki, Hiroki
	Isaka, Yoshitaka
	Kishima, Haruhiko
citation_publisher	Nature Research
citation_language	English
citation_date	2025-07-07
citation_journal_title	Scientific Reports
citation_volume	15
citation_issue	1
citation_firstpage	24204
citation_doi	https://doi.org/10.1038/s41598-025-08942-y
citation_public_url	https://hdl.handle.net/11094/102913

Differences in gut microbiome between autosomal dominant polycystic kidney disease with and without intracranial aneurysms

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