A theoretical interpretation of diffusion weighted and intravoxel incoherent motion imaging for cerebrospinal fluid flow

Otani, Tomohiro; Bito, Yoshitaka; Yamada, Shigeki et al.

Magnetic Resonance in Medicine, 2025

Number of Access:4（2025-11-19 01:29 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/102951

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Title
A theoretical interpretation of diffusion weighted and intravoxel incoherent motion imaging for cerebrospinal fluid flow
Creator
NRID
1000040778990 1000040778990
ORCID
0000-0002-6431-2703 0000-0002-6431-2703
researchmap permalink
bigvalley bigvalley
Scopus Author ID
55625962900 55625962900
CreatorName
Otani, Tomohiro
NRID
1000080789595 1000080789595
CreatorName
Bito, Yoshitaka
NRID
1000040422969 1000040422969
CreatorName
Yamada, Shigeki
NRID
1000020362733 1000020362733
CreatorName
Watanabe, Yoshiyuki
NRID
1000070240546 1000070240546
researchmap permalink
shigeo41010 shigeo41010
Scopus Author ID
7401983636 7401983636
CreatorName
Wada, Shigeo
Subject
cerebrospinal fluid
diffusion
intravoxel incoherent motion
intravoxel standard deviation
neurofluids
Description
Otani T., Bito Y., Yamada S., et al. A theoretical interpretation of diffusion weighted and intravoxel incoherent motion imaging for cerebrospinal fluid flow. Magnetic Resonance in Medicine (2025); https://doi.org/10.1002/mrm.70062.
Abstract
Purpose: Diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) imaging are well-established approaches for evaluating cerebrospinal fluid (CSF) flow in subarachnoid and perivascular spaces, and have recently been applied to study ventricular CSF flow. However, DWI does not directly measure flow velocity, and the physical implications of DWI measurements are unclear. This study aimed to provide a theoretical interpretation of the DWI and IVIM imaging of CSF flow velocity fields. Theory: The general semi-analytical form of the signal attenuations caused by fluid flow and the resultant apparent diffusion coefficient were derived from the Bloch–Torrey equation for arbitrary (Formula presented.) values. Methods: The fundamental properties of the signal attenuation in laminar flow velocity fields were investigated. A Monte Carlo simulation of the IVIM parameter estimation was performed based on these signal attenuations, taking background noise into consideration. Results: The developed theoretical framework indicates that signal attenuations in DWI detect intravoxel flow velocity standard deviations ranging from approximately 0.1 to 10 mm/s within the range of practical scan parameter settings. The lower bounds of the DWI flow profiles appeared where the flow effect was an order of magnitude lower than the molecular diffusion effects, even when (Formula presented.) increased. The IVIM fitting parameters reflected the flow effects of the signal attenuations despite an inconsistency with the original IVIM model assumptions. Conclusion: The physical implications of signal attenuation in DWI have been theoretically clarified. This framework provides a useful basis for understanding CSF flow dynamics and considering appropriate imaging settings.
Publisher
John Wiley and Sons Inc
Source Title
Magnetic Resonance in Medicine
Date of Issued
2025-09-04
Language
English
Handle URL
https://hdl.handle.net/11094/102951
PISSN
07403194
eISSN
15222594
Relation.isIdenticalTo
DOI (Publisher Version)
https://doi.org/10.1002/mrm.70062
Access Rights
open access
CopyRight
This article is licensed under a Creative Commons Attribution 4.0 International License.
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Category
学術雑誌論文 Journal Article