Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney

猪阪, 善隆

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Identifier to cite or link to this item: https://doi.org/10.11501/3075052

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Title
Glomerulosclerosis Induced by in vivo Transfection of transforming Growth Factor-β or Platelet-derived Growth Factor Gene into the Rat Kidney
TGF-β, PDGF遺伝子のラット腎へのin vivo遺伝子導入による糸球体硬化病変の発現
TGF-β, PDGF イデンシ ノ ラット ジン ヘノ in vivo イデンシ ドウニュウ ニ ヨル イトキュウタイ コウカビョウヘン ノ ハッケン
Creator
NRID
1000000379166 1000000379166
researchmap permalink
isaka-handai3857 isaka-handai3857
Scopus Author ID
16207611100 16207611100
ORCID
0000-0002-0820-7167 0000-0002-0820-7167
CreatorName
猪阪, 善隆 ; イサカ, ヨシタカ
Abstract
Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.
Degree Name
博士（医学）
Date of Granted
1994-03-25
Grantor
Osaka University
Faculty
医学
Specialty
内科系
Grant ID
甲第04965号
Description Number
11283
Language
English
Handle URL
https://hdl.handle.net/11094/3168
DOI
https://doi.org/10.11501/3075052
Relation.references
URI
http://www.jci.org/articles/view/116874
Access Rights
open access
CopyRight
© 1993 Journal of Clinical Investigation
oaire:version
Version of Record
Category
Doctoral Thesis with Full Text / Graduate School of Medicine / 1993
Doctoral Thesis / Graduate School of Medicine / 1993