Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments

Shiraki, Tatsuya; Ichibori, Yasuhiro; Ohtani, Tomohito; Mizote, Isamu; Kioka, Hidetaka; Tsukamoto, Yasumasa; Nakamura, Daisuke; Yokoi, Kensuke; Ide, Seiko; Nakamoto, Kei; Takeda, Yasuharu; Kotani, Jun-ichi; Hikoso, Shungo; Sawa, Yoshiki; Sakata, Yasushi

doi:https://doi.org/10.1016/j.healun.2022.03.007

Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments

Shiraki, Tatsuya; Ichibori, Yasuhiro; Ohtani, Tomohito et al.

Journal of Heart and Lung Transplantation, 2022, 41(7), 877-885

Number of Access:265（2025-04-30 13:20 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/90186

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Title	Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments
Creator	NRID 1000060784056 1000060784056 ORCID 0000-0003-1901-1642 0000-0003-1901-1642 researchmap permalink shiraki shiraki Scopus Author ID 56012223900 56012223900 CreatorName Shiraki, Tatsuya
	CreatorName Ichibori, Yasuhiro
	NRID 1000030623897 1000030623897 researchmap permalink tohtani tohtani Scopus Author ID 57932819800 57932819800 CreatorName Ohtani, Tomohito
	NRID 1000010584609 1000010584609 researchmap permalink mizoteisamu mizoteisamu Scopus Author ID 8266113500 8266113500 CreatorName Mizote, Isamu
	NRID 1000070642099 1000070642099 researchmap permalink hkioka hkioka Scopus Author ID 36872909700 36872909700 CreatorName Kioka, Hidetaka
	CreatorName Tsukamoto, Yasumasa
	CreatorName Nakamura, Daisuke
	CreatorName Yokoi, Kensuke
	NRID 1000090624247 1000090624247 researchmap permalink seiko_osaka seiko_osaka Scopus Author ID 55793419500 55793419500 CreatorName Ide, Seiko
	CreatorName Nakamoto, Kei
	NRID 1000090572305 1000090572305 researchmap permalink takeda14 takeda14 Scopus Author ID 35398343900 35398343900 CreatorName Takeda, Yasuharu
	CreatorName Kotani, Jun-ichi
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 6507288830 6507288830 CreatorName Hikoso, Shungo
	NRID 1000000243220 1000000243220 researchmap permalink y-sawa0703 y-sawa0703 Scopus Author ID 55428162700 55428162700 CreatorName Sawa, Yoshiki
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 CreatorName Sakata, Yasushi
Subject	cardiac allograft vasculopathy
	heart transplantation
	interleukin-31
	intravascular ultrasound
	optical coherence tomography
Description	Shiraki T., Ichibori Y., Ohtani T., et al. Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments. Journal of Heart and Lung Transplantation 41, 877 (2022); https://doi.org/10.1016/j.healun.2022.03.007.
Abstract	Background: Detailed morphological characteristics of de novo and donor-transmitted plaques and the association of serum T-lymphocyte cytokine levels with plaque progression of coronary allograft vasculopathy within 1 year after heart transplantation are unknown. Methods: In this retrospective analysis of data in a prospectively maintained database, 40 heart transplant recipients were included. We performed serial 3 vessel optical coherence tomography and intravascular ultrasound analyses, at the 8 week (baseline) and 12 month post-transplantation follow-ups, and serum cytokine measurements (n = 23). The correlation between serum cytokines and Δplaque burden (between baseline and follow-up) was evaluated depending on plaque morphology. Results: Thirteen de novo plaques (maximum intimal thickness ≥0.5 mm at the 12 month follow-up without plaques at baseline) were identified in 8 recipients, and 31 donor-transmitted plaques (maximum intimal thickness ≥0.5 mm at baseline) were detected in 17 recipients. Compared with donor-transmitted plaques, the Δplaque burden in the de novo plaques, with mainly fibrous morphology, was high (38.8% [29.6%–41.2%] vs 8.7% [1.33%–13.6%], p < 0.001). Stratification of the morphology of donor-transmitted plaques revealed that the Δplaque burden in fibrous plaques (10.6% [7.0%–18.0%]) was similar to that in fibroatheroma (10.3% [8.7%–23.8%]). Serum interleukin-31 levels at baseline correlated with fibrous plaque proliferation (r = 0.73, p = 0.007) even under immunosuppressive conditions, whereas other cytokines (interleukin-1β, interleukin-17, and interferon-gamma) were mostly undetectable. Conclusions: Intimal fibrous proliferation contributed to the progression of donor-transmitted and de novo plaques. Serum interleukin-31 levels at baseline may contribute to intimal fibrous proliferation within 1 year after heart transplantation.
Publisher	Elsevier Inc.
Source Title	Journal of Heart and Lung Transplantation
Volume (Issue)	41(7)
Page	877-885
Date of Issued	2022-07-01
Language	English
Handle URL	https://hdl.handle.net/11094/90186
PISSN	10532498
eISSN	15573117
NCID	AA10796579
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1016/j.healun.2022.03.007
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Journal of Heart and Lung Transplantation. 2022, 41(7), p. 877-885
DC.title	Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments
DC.creator	Shiraki, Tatsuya
	Ichibori, Yasuhiro
	Ohtani, Tomohito
	Mizote, Isamu
	Kioka, Hidetaka
	Tsukamoto, Yasumasa
	Nakamura, Daisuke
	Yokoi, Kensuke
	Ide, Seiko
	Nakamoto, Kei
	Takeda, Yasuharu
	Kotani, Jun-ichi
	Hikoso, Shungo
	Sawa, Yoshiki
	Sakata, Yasushi
DC.publisher	Elsevier Inc.
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-07-01
DC.identifier	https://doi.org/10.1016/j.healun.2022.03.007
DC.subject	cardiac allograft vasculopathy
	heart transplantation
	interleukin-31
	intravascular ultrasound
	optical coherence tomography
DC.description	Shiraki T., Ichibori Y., Ohtani T., et al. Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments. Journal of Heart and Lung Transplantation 41, 877 (2022); https://doi.org/10.1016/j.healun.2022.03.007.
DCTERMS.abstract	Background: Detailed morphological characteristics of de novo and donor-transmitted plaques and the association of serum T-lymphocyte cytokine levels with plaque progression of coronary allograft vasculopathy within 1 year after heart transplantation are unknown. Methods: In this retrospective analysis of data in a prospectively maintained database, 40 heart transplant recipients were included. We performed serial 3 vessel optical coherence tomography and intravascular ultrasound analyses, at the 8 week (baseline) and 12 month post-transplantation follow-ups, and serum cytokine measurements (n = 23). The correlation between serum cytokines and Δplaque burden (between baseline and follow-up) was evaluated depending on plaque morphology. Results: Thirteen de novo plaques (maximum intimal thickness ≥0.5 mm at the 12 month follow-up without plaques at baseline) were identified in 8 recipients, and 31 donor-transmitted plaques (maximum intimal thickness ≥0.5 mm at baseline) were detected in 17 recipients. Compared with donor-transmitted plaques, the Δplaque burden in the de novo plaques, with mainly fibrous morphology, was high (38.8% [29.6%–41.2%] vs 8.7% [1.33%–13.6%], p < 0.001). Stratification of the morphology of donor-transmitted plaques revealed that the Δplaque burden in fibrous plaques (10.6% [7.0%–18.0%]) was similar to that in fibroatheroma (10.3% [8.7%–23.8%]). Serum interleukin-31 levels at baseline correlated with fibrous plaque proliferation (r = 0.73, p = 0.007) even under immunosuppressive conditions, whereas other cytokines (interleukin-1β, interleukin-17, and interferon-gamma) were mostly undetectable. Conclusions: Intimal fibrous proliferation contributed to the progression of donor-transmitted and de novo plaques. Serum interleukin-31 levels at baseline may contribute to intimal fibrous proliferation within 1 year after heart transplantation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	90186
citation_title	Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments
citation_author	Shiraki, Tatsuya
	Ichibori, Yasuhiro
	Ohtani, Tomohito
	Mizote, Isamu
	Kioka, Hidetaka
	Tsukamoto, Yasumasa
	Nakamura, Daisuke
	Yokoi, Kensuke
	Ide, Seiko
	Nakamoto, Kei
	Takeda, Yasuharu
	Kotani, Jun-ichi
	Hikoso, Shungo
	Sawa, Yoshiki
	Sakata, Yasushi
citation_publisher	Elsevier Inc.
citation_language	English
citation_date	2022-07-01
citation_journal_title	Journal of Heart and Lung Transplantation
citation_volume	41
citation_issue	7
citation_firstpage	877
citation_lastpage	885
citation_doi	https://doi.org/10.1016/j.healun.2022.03.007
citation_public_url	https://hdl.handle.net/11094/90186

Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments

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