Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases

Hashida, Noriyasu; Nishida, Kohji

Advanced Drug Delivery Reviews, 2023, 198, 114870

Number of Access:448（2025-08-19 01:02 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/91342

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Title
Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases
Creator
NRID
1000030456959 1000030456959
researchmap permalink
nh0814 nh0814
Scopus Author ID
6603280274 6603280274
CreatorName
Hashida, Noriyasu
NRID
1000040244610 1000040244610
ORCID
0000-0001-9069-3610 0000-0001-9069-3610
researchmap permalink
read0131487 read0131487
Scopus Author ID
57211973404 57211973404
CreatorName
Nishida, Kohji
Subject
Age-related macular degeneration
Blood retinal barrier
Clinical trial
Diabetic retinopathy
Drug delivery
Retina
Retinal vein occlusion
Retinitis pigmentosa
Vitreoretinal disease
Vitreous
Abstract
Effective drug therapy for vitreoretinal disease is a major challenge in the field of ophthalmology; various protective systems, including anatomical and physiological barriers, complicate drug delivery to precise targets. However, as the eye is a closed cavity, it is an ideal target for local administration. Various types of drug delivery systems have been investigated that take advantage of this aspect of the eye, enhancing ocular permeability and optimizing local drug concentrations. Many drugs, mainly anti-VEGF drugs, have been evaluated in clinical trials and have provided clinical benefit to many patients. In the near future, innovative drug delivery systems will be developed to avoid frequent intravitreal administration of drugs and maintain effective drug concentrations for a long period of time. Here, we review the published literature on various drugs and administration routes and current clinical applications. Recent advances in drug delivery systems are discussed along with future prospects.
Publisher
Elsevier B.V.
Source Title
Advanced Drug Delivery Reviews
Volume (Issue)
198
Page
114870
Date of Issued
2023-07-01
Language
English
Handle URL
https://hdl.handle.net/11094/91342
PISSN
0169409X
eISSN
18728294
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1016/j.addr.2023.114870
Access Rights
open access
CopyRight
© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article