Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats

Katagiri, Ayano; Yamada, Masaharu; Sato, Hajime; Toyoda, Hiroki; Niwa, Hitoshi; Kato, Takafumi

doi:https://doi.org/10.1007/s10266-023-00887-w

Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats

Katagiri, Ayano; Yamada, Masaharu; Sato, Hajime et al.

Odontology, 2024, 112(3), 906-916

Number of Access:947（2025-08-13 21:03 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/94639

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Title	Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats
Creator	NRID 1000040731899 1000040731899 ORCID 0000-0001-7381-8557 0000-0001-7381-8557 researchmap permalink katagiri-ayano katagiri-ayano Scopus Author ID 47161239400 47161239400 CreatorName Katagiri, Ayano
	CreatorName Yamada, Masaharu
	NRID 1000010432452 1000010432452 CreatorName Sato, Hajime
	NRID 1000000432451 1000000432451 ORCID 0000-0002-9907-7176 0000-0002-9907-7176 researchmap permalink read0210128 read0210128 Scopus Author ID 8708646300 8708646300 CreatorName Toyoda, Hiroki
	NRID 1000030218250 1000030218250 researchmap permalink 19580710 19580710 Scopus Author ID 24351577000 24351577000 CreatorName Niwa, Hitoshi
	NRID 1000050367520 1000050367520 ORCID 0000-0003-2452-7328 0000-0003-2452-7328 researchmap permalink read0111598_hrfc15 read0111598_hrfc15 Scopus Author ID 57210579311 57210579311 CreatorName Kato, Takafumi
Subject	Hypoxic stress
	Intraoral hypersensitivity
	Masticatory function
	Maternal separation
	Suckling-mastication transition period
Description	The version of record of this article, first published in Odontology, is available online at Publisher’s website: https://doi.org/10.1007/s10266-023-00887-w.
Abstract	Early-life stress affects brain development, eventually resulting in adverse behavioral and physical health consequences in adulthood. The present study assessed the hypothesis that short-term early-life stress during infancy before weaning, a period for the maturation of mastication and sleep, poses long-lasting adverse effects on masticatory function and intraoral sensations later in life. Rat pups were exposed to either maternal separation (MS) or intermittent hypoxia (IH-Infancy) for 6 h/day in the light/sleep phase from postnatal day (P)17 to P20 to generate “neglect” and “pediatric obstructive sleep apnea” models, respectively. The remaining rats were exposed to IH during P45–P48 (IH-Adult). Masticatory ability was evaluated based on the rats’ ability to chew pellets and bite pasta throughout the growth period (P21–P70). Intraoral chemical and mechanical sensitivities were assessed using two-bottle preference drinking tests, and hind paw pain thresholds were measured in adulthood (after P60). No differences were found in body weight, grip force, and hind paw sensitivity in MS, IH-Infancy, and IH-Adult rats compared with naïve rats. Masticatory ability was lower in MS and IH-Infancy rats from P28 to P70 than in naïve rats. MS and IH-Infancy rats exhibited intraoral hypersensitivity to capsaicin and mechanical stimulations in adulthood. The IH-Adult rats did not display inferior masticatory ability or intraoral hypersensitivity. In conclusion, short-term early-life stress during the suckling–mastication transition period potentially causes a persistent decrease in masticatory ability and intraoral hypersensitivity in adulthood. The period is a “critical window” for the maturation of oral motor and sensory functions.
Publisher	Springer
Source Title	Odontology
Volume (Issue)	112(3)
Page	906-916
Date of Issued	2024-01-10
Language	English
Handle URL	https://hdl.handle.net/11094/94639
PISSN	16181247
eISSN	16181255
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1007/s10266-023-00887-w
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Odontology. 2024, 112(3), p. 906-916
DC.title	Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats
DC.creator	Katagiri, Ayano
	Yamada, Masaharu
	Sato, Hajime
	Toyoda, Hiroki
	Niwa, Hitoshi
	Kato, Takafumi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-01-10
DC.identifier	https://doi.org/10.1007/s10266-023-00887-w
DC.subject	Hypoxic stress
	Intraoral hypersensitivity
	Masticatory function
	Maternal separation
	Suckling-mastication transition period
DC.description	The version of record of this article, first published in Odontology, is available online at Publisher’s website: https://doi.org/10.1007/s10266-023-00887-w.
DCTERMS.abstract	Early-life stress affects brain development, eventually resulting in adverse behavioral and physical health consequences in adulthood. The present study assessed the hypothesis that short-term early-life stress during infancy before weaning, a period for the maturation of mastication and sleep, poses long-lasting adverse effects on masticatory function and intraoral sensations later in life. Rat pups were exposed to either maternal separation (MS) or intermittent hypoxia (IH-Infancy) for 6 h/day in the light/sleep phase from postnatal day (P)17 to P20 to generate “neglect” and “pediatric obstructive sleep apnea” models, respectively. The remaining rats were exposed to IH during P45–P48 (IH-Adult). Masticatory ability was evaluated based on the rats’ ability to chew pellets and bite pasta throughout the growth period (P21–P70). Intraoral chemical and mechanical sensitivities were assessed using two-bottle preference drinking tests, and hind paw pain thresholds were measured in adulthood (after P60). No differences were found in body weight, grip force, and hind paw sensitivity in MS, IH-Infancy, and IH-Adult rats compared with naïve rats. Masticatory ability was lower in MS and IH-Infancy rats from P28 to P70 than in naïve rats. MS and IH-Infancy rats exhibited intraoral hypersensitivity to capsaicin and mechanical stimulations in adulthood. The IH-Adult rats did not display inferior masticatory ability or intraoral hypersensitivity. In conclusion, short-term early-life stress during the suckling–mastication transition period potentially causes a persistent decrease in masticatory ability and intraoral hypersensitivity in adulthood. The period is a “critical window” for the maturation of oral motor and sensory functions.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	94639
citation_title	Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats
citation_author	Katagiri, Ayano
	Yamada, Masaharu
	Sato, Hajime
	Toyoda, Hiroki
	Niwa, Hitoshi
	Kato, Takafumi
citation_publisher	Springer
citation_language	English
citation_date	2024-01-10
citation_journal_title	Odontology
citation_volume	112
citation_issue	3
citation_firstpage	906
citation_lastpage	916
citation_doi	https://doi.org/10.1007/s10266-023-00887-w
citation_public_url	https://hdl.handle.net/11094/94639

Long-lasting adverse effects of short-term stress during the suckling–mastication transition period on masticatory function and intraoral sensation in rats

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