Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study

Fang, Wen; Godai, Kayo; Kabayama, Mai; Akagi, Yuya; Kido, Michiko; Akasaka, Hiroshi; Takami, Yoichi; Ikebe, Kazunori; Arai, Yasumichi; Masui, Yukie; Ishizaki, Tatsuro; Yasumoto, Saori; Gondo, Yasuyuki; Yamamoto, Koichi; Tabara, Yasuharu; Kamide, Kei

doi:https://doi.org/10.1111/ggi.14876

Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study

Fang, Wen; Godai, Kayo; Kabayama, Mai et al.

Geriatrics and Gerontology International, 2024, 24(6), 529-536

Number of Access:2,574（2025-07-28 10:55 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/95794

Link to primary information

File	Format	Terms of use	Size	Views	Date.Available	Description	information
GeriatrGerontolInt_ggi_14876	pdf	None	533 KB	117	2024.06.03

Creative Commons : Attribution

Item Information

Output File Export EndNote Basic Export Mendeley

Title	Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study
Creator	CreatorName Fang, Wen
	NRID 1000030708681 1000030708681 researchmap permalink vince vince Scopus Author ID 56781372400 56781372400 CreatorName Godai, Kayo
	NRID 1000050635498 1000050635498 ORCID 0000-0003-1394-1152 0000-0003-1394-1152 researchmap permalink kabayama kabayama Scopus Author ID 57031780400 57031780400 CreatorName Kabayama, Mai
	researchmap permalink yuya-akagi yuya-akagi CreatorName Akagi, Yuya
	NRID 1000000706913 1000000706913 researchmap permalink 051010 051010 Scopus Author ID 56086201900 56086201900 CreatorName Kido, Michiko
	NRID 1000070468081 1000070468081 researchmap permalink hiroshi-akasaka hiroshi-akasaka Scopus Author ID 35445539600 35445539600 CreatorName Akasaka, Hiroshi
	NRID 1000090621756 1000090621756 ORCID 0000-0001-9018-6707 0000-0001-9018-6707 researchmap permalink YT-1973 YT-1973 Scopus Author ID 8635744100 8635744100 CreatorName Takami, Yoichi
	NRID 1000070273696 1000070273696 researchmap permalink read0185241 read0185241 Scopus Author ID 35494649700 35494649700 ORCID 0000-0001-5696-6785 0000-0001-5696-6785 CreatorName Ikebe, Kazunori
	NRID 1000020255467 1000020255467 CreatorName Arai, Yasumichi
	NRID 1000010415507 1000010415507 CreatorName Masui, Yukie
	NRID 1000030246045 1000030246045 CreatorName Ishizaki, Tatsuro
	NRID 1000060649317 1000060649317 researchmap permalink GSU GSU Scopus Author ID 36503185600 36503185600 CreatorName Yasumoto, Saori
	NRID 1000040250196 1000040250196 ORCID 0000-0002-9805-2807 0000-0002-9805-2807 researchmap permalink ygondo ygondo Scopus Author ID 55800810400 55800810400 CreatorName Gondo, Yasuyuki
	NRID 1000000528424 1000000528424 ORCID 0000-0003-0107-9315 0000-0003-0107-9315 researchmap permalink kymt0410 kymt0410 Scopus Author ID 55624482466 55624482466 CreatorName Yamamoto, Koichi
	NRID 1000000268749 1000000268749 CreatorName Tabara, Yasuharu
	NRID 1000080393239 1000080393239 researchmap permalink kamide kamide Scopus Author ID 7102978326 7102978326 ORCID 0000-0003-1720-2218 0000-0003-1720-2218 CreatorName Kamide, Kei
Subject	creatinine/cystatin C ratio
	general population
	late-stage older adults
	sarcopenia
	skeletal muscle mass index
Description	Fang W., Godai K., Kabayama M., et al. Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study. Geriatrics and Gerontology International , (2024); https://doi.org/10.1111/ggi.14876.
Abstract	Aim: The serum creatinine/cystatin C ratio (CCR) or sarcopenia index is considered a useful marker of muscle mass. However, its usefulness in late-stage older adults remains unclear. We aimed to determine the usefulness of CCR as an indicator of sarcopenia in community-dwelling Japanese adults aged >75 years. Methods: Our study recruited participants aged 70, 80, and 90 ± 1 years during the baseline years, and included a 3-year follow-up in the Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians study. From 2015 to 2018, 955 participants were eligible: 367 in their 70s, 304 in their 80s, and 284 in their 90s. The diagnostic components of sarcopenia, including “low muscle mass, plus low muscle strength, and/or low physical performance,” were evaluated using the bioelectrical impedance analysis-measured skeletal muscle mass index (SMI), handgrip strength, and short physical performance battery (SPPB) score, respectively, in accordance with the Asia Working Group for Sarcopenia 2019 criteria. Separate analyses were performed between each component and CCR, adjusting for sex, body mass index, and other blood biomarkers in each group. Results: The relationship between CCR and sarcopenia components was significant for handgrip strength (β = 0.21, 0.13, 0.19, and P < 0.0001, =0.0088, <0.0001, for the 70s, 80s, and 90s age groups, respectively); however, it was limited for SMI (β = 0.14; P = 0.0022, only for the 90s) and not significant for the SPPB score. Conclusion: CCR is a limited indicator of sarcopenia in late-stage older adults. Although its association with muscle strength was significant, its relationship with muscle mass and physical performance was less pronounced.
Publisher	John Wiley and Sons Inc
Source Title	Geriatrics and Gerontology International
Volume (Issue)	24(6)
Page	529-536
Date of Issued	2024-04-15
Language	English
Handle URL	https://hdl.handle.net/11094/95794
PISSN	14441586
eISSN	14470594
Relation.isIdenticalTo	DOI (Publisher Version) https://doi.org/10.1111/ggi.14876
Access Rights	open access
CopyRight	This article is licensed under a Creative Commons Attribution 4.0 International License.
oaire:version	Version of Record
Category	学術雑誌論文 Journal Article

Resource Type	journal article
Local Type	Journal Article
DCMI Type	Text
DCTERMS.bibliographicCitation	Geriatrics and Gerontology International. 2024, 24(6), p. 529-536
DC.title	Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study
DC.creator	Fang, Wen
	Godai, Kayo
	Kabayama, Mai
	Akagi, Yuya
	Kido, Michiko
	Akasaka, Hiroshi
	Takami, Yoichi
	Ikebe, Kazunori
	Arai, Yasumichi
	Masui, Yukie
	Ishizaki, Tatsuro
	Yasumoto, Saori
	Gondo, Yasuyuki
	Yamamoto, Koichi
	Tabara, Yasuharu
	Kamide, Kei
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	English
DC.type' scheme='DCTERMS.DCMIType	Text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-04-15
DC.identifier	https://doi.org/10.1111/ggi.14876
DC.subject	creatinine/cystatin C ratio
	general population
	late-stage older adults
	sarcopenia
	skeletal muscle mass index
DC.description	Fang W., Godai K., Kabayama M., et al. Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study. Geriatrics and Gerontology International , (2024); https://doi.org/10.1111/ggi.14876.
DCTERMS.abstract	Aim: The serum creatinine/cystatin C ratio (CCR) or sarcopenia index is considered a useful marker of muscle mass. However, its usefulness in late-stage older adults remains unclear. We aimed to determine the usefulness of CCR as an indicator of sarcopenia in community-dwelling Japanese adults aged >75 years. Methods: Our study recruited participants aged 70, 80, and 90 ± 1 years during the baseline years, and included a 3-year follow-up in the Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians study. From 2015 to 2018, 955 participants were eligible: 367 in their 70s, 304 in their 80s, and 284 in their 90s. The diagnostic components of sarcopenia, including “low muscle mass, plus low muscle strength, and/or low physical performance,” were evaluated using the bioelectrical impedance analysis-measured skeletal muscle mass index (SMI), handgrip strength, and short physical performance battery (SPPB) score, respectively, in accordance with the Asia Working Group for Sarcopenia 2019 criteria. Separate analyses were performed between each component and CCR, adjusting for sex, body mass index, and other blood biomarkers in each group. Results: The relationship between CCR and sarcopenia components was significant for handgrip strength (β = 0.21, 0.13, 0.19, and P < 0.0001, =0.0088, <0.0001, for the 70s, 80s, and 90s age groups, respectively); however, it was limited for SMI (β = 0.14; P = 0.0022, only for the 90s) and not significant for the SPPB score. Conclusion: CCR is a limited indicator of sarcopenia in late-stage older adults. Although its association with muscle strength was significant, its relationship with muscle mass and physical performance was less pronounced.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	95794
citation_title	Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study
citation_author	Fang, Wen
	Godai, Kayo
	Kabayama, Mai
	Akagi, Yuya
	Kido, Michiko
	Akasaka, Hiroshi
	Takami, Yoichi
	Ikebe, Kazunori
	Arai, Yasumichi
	Masui, Yukie
	Ishizaki, Tatsuro
	Yasumoto, Saori
	Gondo, Yasuyuki
	Yamamoto, Koichi
	Tabara, Yasuharu
	Kamide, Kei
citation_publisher	John Wiley and Sons Inc
citation_language	English
citation_date	2024-04-15
citation_journal_title	Geriatrics and Gerontology International
citation_volume	24
citation_issue	6
citation_firstpage	529
citation_lastpage	536
citation_doi	https://doi.org/10.1111/ggi.14876
citation_public_url	https://hdl.handle.net/11094/95794

Usefulness of the serum creatinine/cystatin C ratio as a blood biomarker for sarcopenia components among age groups in community-dwelling older people: The SONIC study

Link to primary information

Item Information

Show details