Numerical Study of Pressure Response to Action Potential by Water Permeation With Ion Transports

Matsuyama, Haruhi; Fujii, Takehiro; Miyauchi, Suguru et al.

ASME Journal of Heat and Mass Transfer, 2024, 146(10), 101202

Number of Access:587（2025-08-15 06:46 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/96428

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Title
Numerical Study of Pressure Response to Action Potential by Water Permeation With Ion Transports
Creator
CreatorName
Matsuyama, Haruhi
CreatorName
Fujii, Takehiro
NRID
1000000758691 1000000758691
CreatorName
Miyauchi, Suguru
NRID
1000050372628 1000050372628
ORCID
0000-0003-0091-4542 0000-0003-0091-4542
researchmap permalink
50372628 50372628
Scopus Author ID
35474283000 35474283000
CreatorName
Takeuchi, Shintaro
Description
Matsuyama Haruhi, Fujii Takehiro, Miyauchi Suguru, et al. Numerical Study of Pressure Response to Action Potential by Water Permeation With Ion Transports. ASME Journal of Heat and Mass Transfer 146, 710 (2024); https://doi.org/10.1115/1.4065675.
Abstract
While the permeation mechanism of solute (e.g., ions and glucose) through biological membrane has been studied extensively, the mechanical role of water transport in intracellular phenomena has not received much attention. In the present study, to investigate the effect of water permeation on the intracellular pressure response, a novel permeation flux model through a biological membrane is developed by incorporating the coupling permeabilities (between water and ion fluxes) as the water–ion interaction in the ion channels. The proposed model is applied to a two–dimensional permeation problem of water and ions in a closed cell separated by a thin membrane. The permeation flux model reproduces the typical time response of intracellular pressure to action potentials with reasonable agreement with experimental results in the literature, indicating that the pressure response can be characterized by the following three parameters: water permeability, the mass ratio of water and ion, and the ratio of the permeation fluxes of water and ion. In particular, the permeation flux ratio plays an essential role in intracellular phenomena; depending on the value of the permeation flux ratio, the time lag between the action potential and the pressure response is 0.1 times smaller than that expected by the previous researchers, indicating that water transport associated with ions may trigger a pressure response. This study demonstrates the importance of water permeation in intracellular mechanical response through coupling of the fluid motion and electric fields.
Publisher
ASME International
Source Title
ASME Journal of Heat and Mass Transfer
Volume (Issue)
146(10)
Page
101202
Date of Issued
2024-10-01
Language
English
Handle URL
https://hdl.handle.net/11094/96428
PISSN
28328450
eISSN
28328469
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1115/1.4065675
Access Rights
embargoed access
CopyRight
The full-text file will be made open to the public on 1 October 2025 in accordance with the publisher's policy.
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article