Pathological mechanisms of kidney disease in ageing

Yamamoto, Takeshi; Isaka, Yoshitaka

Nature Reviews Nephrology, 2024, 20, 603-615

Number of Access:559（2025-09-12 06:32 Counts）

Identifier to cite or link to this item: https://hdl.handle.net/11094/97748

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Title
Pathological mechanisms of kidney disease in ageing
Creator
NRID
1000020756994 1000020756994
researchmap permalink
tyamamoto-handai3857 tyamamoto-handai3857
Scopus Author ID
55628566248 55628566248
ORCID
0009-0007-3817-0557 0009-0007-3817-0557
CreatorName
Yamamoto, Takeshi
NRID
1000000379166 1000000379166
researchmap permalink
isaka-handai3857 isaka-handai3857
Scopus Author ID
16207611100 16207611100
ORCID
0000-0002-0820-7167 0000-0002-0820-7167
CreatorName
Isaka, Yoshitaka
Description
Yamamoto T., Isaka Y.. Pathological mechanisms of kidney disease in ageing. Nature Reviews Nephrology 20, 603 (2024); https://doi.org/10.1038/s41581-024-00868-4.
Abstract
The kidney is a metabolically active organ that requires energy to drive processes such as tubular reabsorption and secretion, and shows a decline in function with advancing age. Various molecular mechanisms, including genomic instability, telomere attrition, inflammation, autophagy, mitochondrial function, and changes to the sirtuin and Klotho signalling pathways, are recognized regulators of individual lifespan and pivotal factors that govern kidney ageing. Thus, mechanisms that contribute to ageing not only dictate renal outcomes but also exert a substantial influence over life expectancy. Conversely, kidney dysfunction, in the context of chronic kidney disease (CKD), precipitates an expedited ageing trajectory in individuals, leading to premature ageing and a disconnect between biological and chronological age. As CKD advances, age-related manifestations such as frailty become increasingly conspicuous. Hence, the pursuit of healthy ageing necessitates not only the management of age-related complications but also a comprehensive understanding of the processes and markers that underlie systemic ageing. Here, we examine the hallmarks of ageing, focusing on the mechanisms by which they affect kidney health and contribute to premature organ ageing. We also review diagnostic methodologies and interventions for premature ageing, with special consideration given to the potential of emerging therapeutic avenues to target age-related kidney diseases.
Publisher
Nature Research
Source Title
Nature Reviews Nephrology
Volume (Issue)
20
Page
603-615
Date of Issued
2024-07-18
Language
English
Handle URL
https://hdl.handle.net/11094/97748
PISSN
17595061
eISSN
1759507X
Relation.isVersionOf
DOI (Publisher Version)
https://doi.org/10.1038/s41581-024-00868-4
Access Rights
open access
oaire:version
Accepted Manuscript
Category
学術雑誌論文 Journal Article